PSAP Products

Description

PSAP is a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D, which are similar to each other and are sphingolipid hydrolase activator proteins. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in PSAP gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy.

Bioinformatics

Entrez	5660 Human
Uniprot	AAH01503 Human AAH04275 Human NM_001042466 Human NM_002778 Human NP_001035930 Human NP_002769.1 Human P07602 Human
Product By Gene ID	5660
Alternate Names	FLJ00245 GLBA proactivator polypeptide prosaposin SAP1MGC110993 sphingolipid activator protein-1

Research Areas for PSAP

Find related products by research area and learn more about each of the different research areas below.

Cancer