PNR/NR2E3 Antibody

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Immunohistochemistry-Paraffin: PNR/NR2E3 Antibody [NLS5770] - Analysis of anti-NR2E3 antibody with human retina at 30 ug/ml.
Immunohistochemistry-Paraffin: PNR/NR2E3 Antibody [NLS5770] - Analysis of anti-NR2E3 antibody with human retina.

Product Details

Summary
Reactivity Hu, Mu, Po, Bt, Bv, Eq, Ha, Mk, PmSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

PNR/NR2E3 Antibody Summary

Immunogen
Synthetic 19 amino acid peptide from ligand-binding domain of human NR2E3.
Specificity
Human NR2E3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Predicted Species
Primate (95%), Monkey (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NR2E3
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 1:10-1:500

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Chimpanzee (100%), Gorilla (100%), Gibbon (100%), Elephant (100%), Panda (100%), Marmoset (95%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for PNR/NR2E3 Antibody

  • NR2E3
  • Nuclear receptor subfamily 2 group E member 3
  • nuclear receptor subfamily 2, group E, member 3
  • photoreceptor-specific nuclear receptor
  • PNR
  • PNRESCS
  • rd7
  • Retina-specific nuclear receptor
  • RNR
  • RP37MGC49976

Background

Photoreceptor-specific nuclear receptor (PNR), a NR2 Hepatocyte NF4-Like Receptor, has been suggested to affect cone cell proliferation in eye development. It has been shown to have a role in determining photoreceptor phenotype during human retinogenesis. In RD7 mice, a deletion in PNR results in hereditary retinal dysplasia and degeneration. A homozygous missense mutation in PNR has been linked to retinitis pigmentosa in Crypto-Jews of Belmonte. Two alternatively spliced isoforms have been documented. PNR is expressed in the retina. ESTs have been isolated from cancerous human lung, colon, and ovary, and from normal human eye.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol NR2E3
Entrez
Uniprot