PKN1 Antibody

• Reactivity: Hu, Mu, Rt, Ca
• Applications: WB, IHC, IHC-P, IP
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated

PKN1 Antibody Summary

• Immunogen: A synthetic peptide corresponding to amino acids 911-929 of human PKN1 (EAPTLSPPRDARPLTAAEQ) was used as immunogen; GenBank no. gi|914098|gb|AAB33345.1|.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PKN1
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:1000-1:5000
  • Immunoprecipitation 1:50-1:200
  • Western Blot 1:1000-1:2000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Whole antisera
• Preservative: 0.05% Sodium Azide
• Purity: Unpurified

Alternate Names for PKN1 Antibody

• DBK
• EC 2.7.11
• MGC46204
• PAK1
• PAK1Serine-threonine protein kinase N
• PKN
• PKN1
• PKN-ALPHA
• PKNPKN-ALPHA
• PRK1
• PRK1PAK-1
• PRKCL1
• PRKCL1protein kinase C-related kinase 1
• Protease-activated kinase 1
• Protein kinase C-like 1EC 2.7.11.13
• Protein kinase C-like PKN
• protein kinase N1
• Protein kinase PKN-alpha
• Protein-kinase C-related kinase 1
• serine/threonine protein kinase N
• serine/threonine-protein kinase N1
• serine-threonine kinase N

Background

PKN1 is encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PKN1
• Entrez:
  • 5585(Human)
• Uniprot:
  • Q16512(Human)