PKN1 Products

Description

PKN1 is encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]

Bioinformatics

Entrez	5585 Human
Uniprot	AAH40061 Human AAH40061.1 Human NM_002741 Human NP_002732 Human Q16512 Human
Product By Gene ID	5585
Alternate Names	DBK EC 2.7.11 MGC46204 PAK1Serine-threonine protein kinase N PKNPKN-ALPHA PRK1PAK-1 PRKCL1protein kinase C-related kinase 1 Protease-activated kinase 1 Protein kinase C-like 1EC 2.7.11.13 Protein kinase C-like PKN protein kinase N1 Protein kinase PKN-alpha Protein-kinase C-related kinase 1 serine/threonine protein kinase N serine/threonine-protein kinase N1 serine-threonine kinase N

Research Areas for PKN1

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Protein Kinase