PEDFR/PNPLA2/ATGL Antibody Blocking Peptide

Product Discontinued

PEDFR/PNPLA2/ATGL Antibody Blocking Peptide Summary

• Description: A PNPLA2 antibody blocking peptide.
• Immunogen: A synthetic peptide within the C-terminal region [residues 400-500] of the human ATGL protein. [NCBI# NP_005171]
• Localization: Adipocytes
• Protein/Peptide Type: Antibody Blocking Peptide
• Gene: PNPLA2

Applications/Dilutions

• Dilutions:
  • Antibody Competition
• Application Notes: This peptide is useful as a blocking peptide for NB110-41536.
  
  For further blocking peptide related protocol, click here.

Packaging, Storage & Formulations

• Storage: Store at -80C. Avoid freeze-thaw cycles.
• Buffer: DH20
• Preservative: No Preservative
• Concentration: 1.0 mg/ml

Alternate Names for PEDFR/PNPLA2/ATGL Antibody Blocking Peptide

• Adipose triglyceride lipase
• ATGL
• ATGL1110001C14Rik
• Calcium-independent phospholipase A2
• Desnutrin
• EC 3.1.1.3
• FP17548
• IPLA2-zeta
• patatin-like phospholipase domain containing 2
• patatin-like phospholipase domain-containing protein 2
• patatin-like phospholipase domain-containing protein 2-like
• PEDF R
• PEDFR
• PEDF-R
• Pigment epithelium-derived factor
• PNPLA2
• Transport-secretion protein 2
• transport-secretion protein 2.2
• triglyceride hydrolase
• TTS2
• TTS2.2
• TTS-2.2
• TTS2DKFZp667M109

Background

Patatin-like phospholipase domain-containing protein 2 (PNPLA2), also known as adipose triglyceride lipase (ATGL), is a lipolytic enzyme required for mobilization of fatty acids from triglyceride stores in adipose tissue. Until recently, hormone-sensitive lipase (HSL) was the only enzyme known to hydrolyze triglycerides in mammalian adipose tissue. However, ATGL has now been shown to catalyze the initial step of triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Thus, ATGL and HSL coordinate to catabolize stored triglycerides in adipose tissue of mammals.

Defects in PNPLA2 can lead to neutral lipid storage disease with myopathy (NLSDM), a neutral lipid storage disorder with myopathy but without ichthyosis.

ATGL antibodies can serve as useful tools for adipocyte studies and research on triglyceride processing and fat storage.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: PNPLA2