PDGFR alpha Antibody

Recombinant Human PDGF‑AA (Catalog # 221-AA) stimulates proliferation in the WS-1 human fetal skin fibroblast cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Human PDGF‑AA (10 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human PDGF R alpha Antigen Affinity-purified Polyclonal Antibody (Catalog # AF‑307‑NA). The ND50 is typically 1-6 µg/mL.

PDGF Ra was detected in immersion fixed paraffin-embedded sections of human breast cancer tissue using Goat Anti-Human PDGF Ra Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-307-NA) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Lower panel shows a lack of labeling if primary antibodies are omitted and tissue is stained only with secondary antibody followed by incubation with detection reagents. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

PDGF Ra was detected in immersion fixed paraffin-embedded sections of human ovarian array using Goat Anti-Human PDGF Ra Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-307-NA) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

PDGF Ra was detected in immersion fixed paraffin-embedded sections of human osteosarcoma using Goat Anti-Human PDGF Ra Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-307-NA) at 3 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Specific staining was localized to plasma membranes. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Representative light and fluorescence microscopy photomicrographs of normal human corneal sections. (A–C) CD34 immunoperoxidase‐based immunohistochemistry with haematoxylin counterstain. (A) CD34‐positive stromal cells are orderly arranged and parallel to the corneal surface. (B and C) At higher magnification, the CD34‐positive stromal cells appear as spindle‐shaped cells with a small oval body and typically two long and thin moniliform cell processes characterized by the alternation of slender segments (arrows) and knobs/dilations (arrowheads) along their length. (D–I) Double immunofluorescence labelling for CD34 (red) and PDGFR alpha (green) with DAPI (blue) counterstain for nuclei. Colocalization of CD34 and PDGFR alpha in stromal cells gives rise to yellow staining either in the anterior corneal stroma (D–F) or in the deeper corneal stromal layer (G–I). CD34+/PDGFR alpha + stromal cells display cell morphologies very evocative for telocytes: a small cell body with very long prolongations (telopodes) characterized by a moniliform silhouette with the alternation of podoms (arrowheads) and podomers (arrows). (J–L) Double immunofluorescence labelling for CD34 (red) and c‐kit (green) with DAPI (blue) counterstain for nuclei. Either in the subepithelial corneal stroma or in the deeper stromal layer, numerous CD34‐positive stromal cells coexpress c‐kit. Inset: Higher magnification view of CD34+/c‐kit+ corneal stromal cells. Scale bar: 50 μm (A, D–F and J–L), 25 μm (B, C and G–I). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28714595), licensed under a CC-BY license. Not internally tested by R&D Systems.

Representative light and fluorescence microscopy photomicrographs of normal and keratoconic human corneal sections. (A and B) CD34 immunoperoxidase‐based immunohistochemistry with haematoxylin counterstain. (A) In control normal corneas, CD34‐positive stromal cells displaying morphological features of telocytes are orderly arranged and parallel to the corneal surface. (B) In keratoconus, a patchy loss of CD34‐positive stromal cells is mostly evident in the anterior corneal stroma. Insets: Higher magnification views of CD34‐positive corneal stromal cells. (C) Results of quantitative analysis of CD34‐positive telocyte counts per high‐power field in the corneal stroma of healthy controls (n = 6) and patients with keratoconus (n = 6). Data are mean ± S.D. *P < 0.001 versus control. (D–I) Double immunofluorescence labelling for CD34 (red) and PDGFR alpha (green) with DAPI (blue) counterstain for nuclei. (D–F) In control normal corneas, CD34+/PDGFR alpha + stromal cells (telocytes) are orderly distributed throughout the stromal compartment. (G–I) In keratoconic corneas, a patchy loss of CD34+/PDGFR alpha + stromal cells (telocytes) is mainly evident in the subepithelial stroma. (J and K) Double immunofluorescence labelling for CD34 (red) and c‐kit (green) with DAPI (blue) counterstain for nuclei. (J) In control normal corneas, numerous CD34+/c‐kit+ stromal cells (telocytes) are present throughout the stromal layer. (K) In keratoconic corneas, the CD34+/c‐kit+ stromal cell subpopulation is almost completely lost. (L) Results of quantitative analysis of c‐kit‐positive telocyte counts per high‐power field in the corneal stroma of healthy controls (n = 6) and patients with keratoconus (n = 6). Data are mean ± S.D. *P < 0.001 versus control. TC: telocytes; hpf: high‐power field. Scale bar: 100 μm (A and B), 50 μm (D–K). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28714595), licensed under a CC-BY license. Not internally tested by R&D Systems.

Representative light and fluorescence microscopy photomicrographs of normal and keratoconic human corneal sections. (A and B) CD34 immunoperoxidase‐based immunohistochemistry with haematoxylin counterstain. (A) In control normal corneas, CD34‐positive stromal cells displaying morphological features of telocytes are orderly arranged and parallel to the corneal surface. (B) In keratoconus, a patchy loss of CD34‐positive stromal cells is mostly evident in the anterior corneal stroma. Insets: Higher magnification views of CD34‐positive corneal stromal cells. (C) Results of quantitative analysis of CD34‐positive telocyte counts per high‐power field in the corneal stroma of healthy controls (n = 6) and patients with keratoconus (n = 6). Data are mean ± S.D. *P < 0.001 versus control. (D–I) Double immunofluorescence labelling for CD34 (red) and PDGFR alpha (green) with DAPI (blue) counterstain for nuclei. (D–F) In control normal corneas, CD34+/PDGFR alpha + stromal cells (telocytes) are orderly distributed throughout the stromal compartment. (G–I) In keratoconic corneas, a patchy loss of CD34+/PDGFR alpha + stromal cells (telocytes) is mainly evident in the subepithelial stroma. (J and K) Double immunofluorescence labelling for CD34 (red) and c‐kit (green) with DAPI (blue) counterstain for nuclei. (J) In control normal corneas, numerous CD34+/c‐kit+ stromal cells (telocytes) are present throughout the stromal layer. (K) In keratoconic corneas, the CD34+/c‐kit+ stromal cell subpopulation is almost completely lost. (L) Results of quantitative analysis of c‐kit‐positive telocyte counts per high‐power field in the corneal stroma of healthy controls (n = 6) and patients with keratoconus (n = 6). Data are mean ± S.D. *P < 0.001 versus control. TC: telocytes; hpf: high‐power field. Scale bar: 100 μm (A and B), 50 μm (D–K). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28714595), licensed under a CC-BY license. Not internally tested by R&D Systems.

Representative light and fluorescence microscopy photomicrographs of normal and keratoconic human corneal sections. (A and B) CD34 immunoperoxidase‐based immunohistochemistry with haematoxylin counterstain. (A) In control normal corneas, CD34‐positive stromal cells displaying morphological features of telocytes are orderly arranged and parallel to the corneal surface. (B) In keratoconus, a patchy loss of CD34‐positive stromal cells is mostly evident in the anterior corneal stroma. Insets: Higher magnification views of CD34‐positive corneal stromal cells. (C) Results of quantitative analysis of CD34‐positive telocyte counts per high‐power field in the corneal stroma of healthy controls (n = 6) and patients with keratoconus (n = 6). Data are mean ± S.D. *P < 0.001 versus control. (D–I) Double immunofluorescence labelling for CD34 (red) and PDGFR alpha (green) with DAPI (blue) counterstain for nuclei. (D–F) In control normal corneas, CD34+/PDGFR alpha + stromal cells (telocytes) are orderly distributed throughout the stromal compartment. (G–I) In keratoconic corneas, a patchy loss of CD34+/PDGFR alpha + stromal cells (telocytes) is mainly evident in the subepithelial stroma. (J and K) Double immunofluorescence labelling for CD34 (red) and c‐kit (green) with DAPI (blue) counterstain for nuclei. (J) In control normal corneas, numerous CD34+/c‐kit+ stromal cells (telocytes) are present throughout the stromal layer. (K) In keratoconic corneas, the CD34+/c‐kit+ stromal cell subpopulation is almost completely lost. (L) Results of quantitative analysis of c‐kit‐positive telocyte counts per high‐power field in the corneal stroma of healthy controls (n = 6) and patients with keratoconus (n = 6). Data are mean ± S.D. *P < 0.001 versus control. TC: telocytes; hpf: high‐power field. Scale bar: 100 μm (A and B), 50 μm (D–K). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28714595), licensed under a CC-BY license. Not internally tested by R&D Systems.

Representative light and fluorescence microscopy photomicrographs of normal human corneal sections. (A–C) CD34 immunoperoxidase‐based immunohistochemistry with haematoxylin counterstain. (A) CD34‐positive stromal cells are orderly arranged and parallel to the corneal surface. (B and C) At higher magnification, the CD34‐positive stromal cells appear as spindle‐shaped cells with a small oval body and typically two long and thin moniliform cell processes characterized by the alternation of slender segments (arrows) and knobs/dilations (arrowheads) along their length. (D–I) Double immunofluorescence labelling for CD34 (red) and PDGFR alpha (green) with DAPI (blue) counterstain for nuclei. Colocalization of CD34 and PDGFR alpha in stromal cells gives rise to yellow staining either in the anterior corneal stroma (D–F) or in the deeper corneal stromal layer (G–I). CD34+/PDGFR alpha + stromal cells display cell morphologies very evocative for telocytes: a small cell body with very long prolongations (telopodes) characterized by a moniliform silhouette with the alternation of podoms (arrowheads) and podomers (arrows). (J–L) Double immunofluorescence labelling for CD34 (red) and c‐kit (green) with DAPI (blue) counterstain for nuclei. Either in the subepithelial corneal stroma or in the deeper stromal layer, numerous CD34‐positive stromal cells coexpress c‐kit. Inset: Higher magnification view of CD34+/c‐kit+ corneal stromal cells. Scale bar: 50 μm (A, D–F and J–L), 25 μm (B, C and G–I). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28714595), licensed under a CC-BY license. Not internally tested by R&D Systems.

Representative light and fluorescence microscopy photomicrographs of normal and keratoconic human corneal sections. (A and B) CD34 immunoperoxidase‐based immunohistochemistry with haematoxylin counterstain. (A) In control normal corneas, CD34‐positive stromal cells displaying morphological features of telocytes are orderly arranged and parallel to the corneal surface. (B) In keratoconus, a patchy loss of CD34‐positive stromal cells is mostly evident in the anterior corneal stroma. Insets: Higher magnification views of CD34‐positive corneal stromal cells. (C) Results of quantitative analysis of CD34‐positive telocyte counts per high‐power field in the corneal stroma of healthy controls (n = 6) and patients with keratoconus (n = 6). Data are mean ± S.D. *P < 0.001 versus control. (D–I) Double immunofluorescence labelling for CD34 (red) and PDGFR alpha (green) with DAPI (blue) counterstain for nuclei. (D–F) In control normal corneas, CD34+/PDGFR alpha + stromal cells (telocytes) are orderly distributed throughout the stromal compartment. (G–I) In keratoconic corneas, a patchy loss of CD34+/PDGFR alpha + stromal cells (telocytes) is mainly evident in the subepithelial stroma. (J and K) Double immunofluorescence labelling for CD34 (red) and c‐kit (green) with DAPI (blue) counterstain for nuclei. (J) In control normal corneas, numerous CD34+/c‐kit+ stromal cells (telocytes) are present throughout the stromal layer. (K) In keratoconic corneas, the CD34+/c‐kit+ stromal cell subpopulation is almost completely lost. (L) Results of quantitative analysis of c‐kit‐positive telocyte counts per high‐power field in the corneal stroma of healthy controls (n = 6) and patients with keratoconus (n = 6). Data are mean ± S.D. *P < 0.001 versus control. TC: telocytes; hpf: high‐power field. Scale bar: 100 μm (A and B), 50 μm (D–K). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28714595), licensed under a CC-BY license. Not internally tested by R&D Systems.

Representative light and fluorescence microscopy photomicrographs of normal and keratoconic human corneal sections. (A and B) CD34 immunoperoxidase‐based immunohistochemistry with haematoxylin counterstain. (A) In control normal corneas, CD34‐positive stromal cells displaying morphological features of telocytes are orderly arranged and parallel to the corneal surface. (B) In keratoconus, a patchy loss of CD34‐positive stromal cells is mostly evident in the anterior corneal stroma. Insets: Higher magnification views of CD34‐positive corneal stromal cells. (C) Results of quantitative analysis of CD34‐positive telocyte counts per high‐power field in the corneal stroma of healthy controls (n = 6) and patients with keratoconus (n = 6). Data are mean ± S.D. *P < 0.001 versus control. (D–I) Double immunofluorescence labelling for CD34 (red) and PDGFR alpha (green) with DAPI (blue) counterstain for nuclei. (D–F) In control normal corneas, CD34+/PDGFR alpha + stromal cells (telocytes) are orderly distributed throughout the stromal compartment. (G–I) In keratoconic corneas, a patchy loss of CD34+/PDGFR alpha + stromal cells (telocytes) is mainly evident in the subepithelial stroma. (J and K) Double immunofluorescence labelling for CD34 (red) and c‐kit (green) with DAPI (blue) counterstain for nuclei. (J) In control normal corneas, numerous CD34+/c‐kit+ stromal cells (telocytes) are present throughout the stromal layer. (K) In keratoconic corneas, the CD34+/c‐kit+ stromal cell subpopulation is almost completely lost. (L) Results of quantitative analysis of c‐kit‐positive telocyte counts per high‐power field in the corneal stroma of healthy controls (n = 6) and patients with keratoconus (n = 6). Data are mean ± S.D. *P < 0.001 versus control. TC: telocytes; hpf: high‐power field. Scale bar: 100 μm (A and B), 50 μm (D–K). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28714595), licensed under a CC-BY license. Not internally tested by R&D Systems.

Representative light and fluorescence microscopy photomicrographs of normal human corneal sections. (A–C) CD34 immunoperoxidase‐based immunohistochemistry with haematoxylin counterstain. (A) CD34‐positive stromal cells are orderly arranged and parallel to the corneal surface. (B and C) At higher magnification, the CD34‐positive stromal cells appear as spindle‐shaped cells with a small oval body and typically two long and thin moniliform cell processes characterized by the alternation of slender segments (arrows) and knobs/dilations (arrowheads) along their length. (D–I) Double immunofluorescence labelling for CD34 (red) and PDGFR alpha (green) with DAPI (blue) counterstain for nuclei. Colocalization of CD34 and PDGFR alpha in stromal cells gives rise to yellow staining either in the anterior corneal stroma (D–F) or in the deeper corneal stromal layer (G–I). CD34+/PDGFR alpha + stromal cells display cell morphologies very evocative for telocytes: a small cell body with very long prolongations (telopodes) characterized by a moniliform silhouette with the alternation of podoms (arrowheads) and podomers (arrows). (J–L) Double immunofluorescence labelling for CD34 (red) and c‐kit (green) with DAPI (blue) counterstain for nuclei. Either in the subepithelial corneal stroma or in the deeper stromal layer, numerous CD34‐positive stromal cells coexpress c‐kit. Inset: Higher magnification view of CD34+/c‐kit+ corneal stromal cells. Scale bar: 50 μm (A, D–F and J–L), 25 μm (B, C and G–I). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28714595), licensed under a CC-BY license. Not internally tested by R&D Systems.

Representative light and fluorescence microscopy photomicrographs of normal human corneal sections. (A–C) CD34 immunoperoxidase‐based immunohistochemistry with haematoxylin counterstain. (A) CD34‐positive stromal cells are orderly arranged and parallel to the corneal surface. (B and C) At higher magnification, the CD34‐positive stromal cells appear as spindle‐shaped cells with a small oval body and typically two long and thin moniliform cell processes characterized by the alternation of slender segments (arrows) and knobs/dilations (arrowheads) along their length. (D–I) Double immunofluorescence labelling for CD34 (red) and PDGFR alpha (green) with DAPI (blue) counterstain for nuclei. Colocalization of CD34 and PDGFR alpha in stromal cells gives rise to yellow staining either in the anterior corneal stroma (D–F) or in the deeper corneal stromal layer (G–I). CD34+/PDGFR alpha + stromal cells display cell morphologies very evocative for telocytes: a small cell body with very long prolongations (telopodes) characterized by a moniliform silhouette with the alternation of podoms (arrowheads) and podomers (arrows). (J–L) Double immunofluorescence labelling for CD34 (red) and c‐kit (green) with DAPI (blue) counterstain for nuclei. Either in the subepithelial corneal stroma or in the deeper stromal layer, numerous CD34‐positive stromal cells coexpress c‐kit. Inset: Higher magnification view of CD34+/c‐kit+ corneal stromal cells. Scale bar: 50 μm (A, D–F and J–L), 25 μm (B, C and G–I). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28714595), licensed under a CC-BY license. Not internally tested by R&D Systems.

Representative light and fluorescence microscopy photomicrographs of normal human corneal sections. (A–C) CD34 immunoperoxidase‐based immunohistochemistry with haematoxylin counterstain. (A) CD34‐positive stromal cells are orderly arranged and parallel to the corneal surface. (B and C) At higher magnification, the CD34‐positive stromal cells appear as spindle‐shaped cells with a small oval body and typically two long and thin moniliform cell processes characterized by the alternation of slender segments (arrows) and knobs/dilations (arrowheads) along their length. (D–I) Double immunofluorescence labelling for CD34 (red) and PDGFR alpha (green) with DAPI (blue) counterstain for nuclei. Colocalization of CD34 and PDGFR alpha in stromal cells gives rise to yellow staining either in the anterior corneal stroma (D–F) or in the deeper corneal stromal layer (G–I). CD34+/PDGFR alpha + stromal cells display cell morphologies very evocative for telocytes: a small cell body with very long prolongations (telopodes) characterized by a moniliform silhouette with the alternation of podoms (arrowheads) and podomers (arrows). (J–L) Double immunofluorescence labelling for CD34 (red) and c‐kit (green) with DAPI (blue) counterstain for nuclei. Either in the subepithelial corneal stroma or in the deeper stromal layer, numerous CD34‐positive stromal cells coexpress c‐kit. Inset: Higher magnification view of CD34+/c‐kit+ corneal stromal cells. Scale bar: 50 μm (A, D–F and J–L), 25 μm (B, C and G–I). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28714595), licensed under a CC-BY license. Not internally tested by R&D Systems.

Representative light and fluorescence microscopy photomicrographs of normal human corneal sections. (A–C) CD34 immunoperoxidase‐based immunohistochemistry with haematoxylin counterstain. (A) CD34‐positive stromal cells are orderly arranged and parallel to the corneal surface. (B and C) At higher magnification, the CD34‐positive stromal cells appear as spindle‐shaped cells with a small oval body and typically two long and thin moniliform cell processes characterized by the alternation of slender segments (arrows) and knobs/dilations (arrowheads) along their length. (D–I) Double immunofluorescence labelling for CD34 (red) and PDGFR alpha (green) with DAPI (blue) counterstain for nuclei. Colocalization of CD34 and PDGFR alpha in stromal cells gives rise to yellow staining either in the anterior corneal stroma (D–F) or in the deeper corneal stromal layer (G–I). CD34+/PDGFR alpha + stromal cells display cell morphologies very evocative for telocytes: a small cell body with very long prolongations (telopodes) characterized by a moniliform silhouette with the alternation of podoms (arrowheads) and podomers (arrows). (J–L) Double immunofluorescence labelling for CD34 (red) and c‐kit (green) with DAPI (blue) counterstain for nuclei. Either in the subepithelial corneal stroma or in the deeper stromal layer, numerous CD34‐positive stromal cells coexpress c‐kit. Inset: Higher magnification view of CD34+/c‐kit+ corneal stromal cells. Scale bar: 50 μm (A, D–F and J–L), 25 μm (B, C and G–I). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28714595), licensed under a CC-BY license. Not internally tested by R&D Systems.

Representative light and fluorescence microscopy photomicrographs of normal and keratoconic human corneal sections. (A and B) CD34 immunoperoxidase‐based immunohistochemistry with haematoxylin counterstain. (A) In control normal corneas, CD34‐positive stromal cells displaying morphological features of telocytes are orderly arranged and parallel to the corneal surface. (B) In keratoconus, a patchy loss of CD34‐positive stromal cells is mostly evident in the anterior corneal stroma. Insets: Higher magnification views of CD34‐positive corneal stromal cells. (C) Results of quantitative analysis of CD34‐positive telocyte counts per high‐power field in the corneal stroma of healthy controls (n = 6) and patients with keratoconus (n = 6). Data are mean ± S.D. *P < 0.001 versus control. (D–I) Double immunofluorescence labelling for CD34 (red) and PDGFR alpha (green) with DAPI (blue) counterstain for nuclei. (D–F) In control normal corneas, CD34+/PDGFR alpha + stromal cells (telocytes) are orderly distributed throughout the stromal compartment. (G–I) In keratoconic corneas, a patchy loss of CD34+/PDGFR alpha + stromal cells (telocytes) is mainly evident in the subepithelial stroma. (J and K) Double immunofluorescence labelling for CD34 (red) and c‐kit (green) with DAPI (blue) counterstain for nuclei. (J) In control normal corneas, numerous CD34+/c‐kit+ stromal cells (telocytes) are present throughout the stromal layer. (K) In keratoconic corneas, the CD34+/c‐kit+ stromal cell subpopulation is almost completely lost. (L) Results of quantitative analysis of c‐kit‐positive telocyte counts per high‐power field in the corneal stroma of healthy controls (n = 6) and patients with keratoconus (n = 6). Data are mean ± S.D. *P < 0.001 versus control. TC: telocytes; hpf: high‐power field. Scale bar: 100 μm (A and B), 50 μm (D–K). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28714595), licensed under a CC-BY license. Not internally tested by R&D Systems.

• Reactivity: Hu
• Applications: WB, IHC, B/N
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: LYOPH

PDGFR alpha Antibody Summary

• Immunogen: S. frugiperda insect ovarian cell line Sf 21-derived recombinant human PDGF R alpha
  Gln24-Glu524
  Accession # P16234
• Specificity: Detects human PDGF R alpha in direct ELISAs and Western blots. In direct ELISAs, less than 2% cross-reactivity with recombinant mouse PDGF R alpha , recombinant human (rh) PDGF R beta , rhFGF R2, and rhFGF R3 is observed.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: PDGFRA
• Purity Statement: Antigen Affinity-purified
• Endotoxin Note: <0.10 EU per 1 μg of the antibody by the LAL method.

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 5-15 ug/mL
  • Neutralization 1-6 ug/mL
  • Western Blot 0.1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for PDGFR alpha Antibody

• alpha-type platelet-derived growth factor receptor
• CD140 antigen-like family member A
• CD140a antigen
• CD140a
• EC 2.7.10
• EC 2.7.10.1
• MGC74795
• PDGF R alpha
• PDGFR alpha
• PDGFR2
• PDGFRA
• PDGFRA/BCR fusion
• PDGF-R-alpha
• platelet-derived growth factor receptor, alpha polypeptide
• rearranged-in-hypereosinophilia-platelet derived growth factor receptor alphafusion protein
• RHEPDGFRA

Background

PDGF is a major serum mitogen that can exist as a homo- or heterodimeric protein consisting of disulfide-linked PDGF-A and PDGF-B chains. The PDGF‑AA, PDGF‑BB, and PDGF‑AB isoforms have been shown to bind to two distinct cell surface PDGF receptors with different affinities. Whereas PDGF R alpha binds all three PDGF isoforms with high affinity, PDGF R beta binds PDGF-BB and -AB, but not PDGF-AA. Both PDGF R alpha and PDGF R beta are members of the class III subfamily of receptor tyrosine kinases (RTK) that also includes the receptors for M-CSF, SCF, and Flt-3 ligand. All class III RTKs are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGF binding induces receptor homo-and heterodimerization and signal transduction. The expression of the alpha and beta receptors is independently regulated in various cell types. Only PDGF R alpha is expressed in oligodendrocyte progenitor cells, mesothelial cell, and liver endothelial cells. Soluble PDGF R alpha has been detected in cell conditioned medium and human plasma. Recombinant soluble PDGF R alpha binds PDGF with high affinity and is a potent PDGF antagonist (1).

1. Heldin, C.H. and L. Claesson-Welsh (1994) Guidebook to Cytokines and Their Receptors, Nicola, N.A. (ed) Oxford University Press, New York, NY p. 202.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for PDGFR alpha Antibody (AF-307-NA)(59)

Publications using AF-307-NA

• Shi, XY;He, YX;Ge, MY;Liu, P;Zheng, P;Li, ZH; Gastrodin promotes CNS myelinogenesis and alleviates demyelinating injury by activating the PI3K/AKT/mTOR signaling Acta pharmacologica Sinica 2025-02-26 [PMID: 40011630] (Immunohistochemistry, Immunocytochemistry, Mouse)
• Balcomb, K;Johnston, C;Kavanagh, T;Leitner, D;Schneider, J;Halliday, G;Wisniewski, T;Sunde, M;Drummond, E; SMOC1 colocalizes with Alzheimer's disease neuropathology and delays A? aggregation Acta Neuropathologica 2024-11-25 [PMID: 39585417] (Immunohistochemistry, Human)
• Santos, AJM;van Unen, V;Lin, Z;Chirieleison, SM;Ha, N;Batish, A;Chan, JE;Cedano, J;Zhang, ET;Mu, Q;Guh-Siesel, A;Tomaske, M;Colburg, D;Varma, S;Choi, SS;Christophersen, A;Baghdasaryan, A;Yost, KE;Karlsson, K;Ha, A;Li, J;Dai, H;Sellers, ZM;Chang, HY;Dunn, JCY;Zhang, BM;Mellins, ED;Sollid, LM;Fernandez-Becker, NQ;Davis, MM;Kuo, CJ; A human autoimmune organoid model reveals IL-7 function in coeliac disease Nature 2024-07-24 [PMID: 39048815] (Immunohistochemistry, Human)
• Sun, Z;Chen, Z;Yin, M;Wu, X;Guo, B;Cheng, X;Quan, R;Sun, Y;Zhang, Q;Fan, Y;Jin, C;Yin, Y;Hou, X;Liu, W;Shu, M;Xue, X;Shi, Y;Chen, B;Xiao, Z;Dai, J;Zhao, Y; Harnessing developmental dynamics of spinal cord extracellular matrix improves regenerative potential of spinal cord organoids Cell stem cell 2024-03-26 [PMID: 38565140] (Immunohistochemistry, Rabbit, Rat)
• Huycke, TR;Miyazaki, H;Häkkinen, TJ;Srivastava, V;Barruet, E;McGinnis, CS;Kalantari, A;Cornwall-Scoones, J;Vaka, D;Zhu, Q;Jo, H;DeGrado, WF;Thomson, M;Garikipati, K;Boffelli, D;Klein, OD;Gartner, ZJ; Patterning and folding of intestinal villi by active mesenchymal dewetting bioRxiv : the preprint server for biology 2023-06-26 [PMID: 37425793] (IHC, Human)
• Huang, Z;Lin, J;Jiang, H;Lin, W;Huang, Z;Chen, J;Xiao, W;Lin, Q;Wang, J;Wen, S;Zhu, Q;Liu, J; Metformin promotes Schwann cell remyelination, preserves neural tissue and improves functional recovery after spinal cord injury Neuropeptides 2023-05-19 [PMID: 37236132] (IHC, Mouse)
• Weifeng Li, Cynthia Berlinicke, Yinyin Huang, Stefanie Giera, Anna G. McGrath, Weixiang Fang et al. High-throughput screening for myelination promoting compounds using human stem cell-derived oligodendrocyte progenitor cells iScience 3/17/2023 [PMID: 36852281]
• Veronika Aleksandrovych, Tomasz Bereza, Magdalena Ulatowska-Białas, Artur Pasternak, Jerzy A. A. Walocha, Kazimierz Pityński et al. Identification of PDGFR alpha + cells in uterine fibroids – link between angiogenesis and uterine telocytes Archives of Medical Science 2019-07-22 [PMID: 36160340]
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Reviews for PDGFR alpha Antibody (AF-307-NA) (2)

Average Rating: 4

(Based on 2 reviews)

We have 2 reviews tested in 2 species: Human, Mouse.

reviewed by: Verified Customer IHC-Fr Human 02/22/2019

Summary

• Application: Immunohistochemistry-Frozen
• Sample Tested: human dermal fibroblasts
• Species: Human
• Lot: VG0718081

reviewed by: Verified Customer IHC Mouse 05/17/2017

Summary

• Application: Immunohistochemistry
• Sample Tested: brain and spinal cord
• Species: Mouse
• Lot: vg026021

Comments

• Comments: worked on mouse spinal cord

Bioinformatics

• Gene Symbol: PDGFRA
• Uniprot:
  • P16234()