PDGFR alpha Antibody (PDGFR-H7A) - BSA Free

• Reactivity: Hu
• Applications: IP
• Clone: PDGFR-H7A
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

PDGFR alpha Antibody (PDGFR-H7A) - BSA Free Summary

• Immunogen: Recombinant protein corresponding to amino acids 1 to 78 of human PDGFR alpha
• Isotype: IgG1 Lambda
• Clonality: Monoclonal
• Host: Mouse
• Gene: PDGFRA
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation 1:10 - 1:500
• Application Notes: Positive control(s): Human Hela cell line.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Protein A purified

Alternate Names for PDGFR alpha Antibody (PDGFR-H7A) - BSA Free

• alpha-type platelet-derived growth factor receptor
• CD140 antigen-like family member A
• CD140a antigen
• CD140a
• EC 2.7.10
• EC 2.7.10.1
• MGC74795
• PDGF R alpha
• PDGFR alpha
• PDGFR2
• PDGFRA
• PDGFRA/BCR fusion
• PDGF-R-alpha
• platelet-derived growth factor receptor, alpha polypeptide
• rearranged-in-hypereosinophilia-platelet derived growth factor receptor alphafusion protein
• RHEPDGFRA

Background

Platelet-derived growth factor receptors exhibit tyrosine-protein kinase activity and have been implicated in the control of cell proliferation, survival and migration. PDGF receptors, PDGFR-alpha and PDGFR-beta, have 5 extracellular immunoglobulin-like domains and an intracellular tyrosine kinase domain. Upon binding a PDGF, the receptors form homo-and heterodimers. Dimerization of the receptors results in phosphorylation in the complex. More than 10 different SH2-domain-containing molecules have been shown to bind to different autophosphorylation sites in the PDGF-alpha and beta receptors. PDGF alpha receptors are expressed in oligodendrocyte progenitor cells and PDGF beta receptors are expressed on neurons.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for PDGFR alpha Antibody (NBP2-50239)(1)

Publication using NBP2-50239

• Haag D, Mack N, Benites Goncalves da Silva P et al. H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model Cancer cell 2021-01-29 [PMID: 33545065]

Bioinformatics

• Gene Symbol: PDGFRA