PDCD5 Antibody - BSA Free

Western Blot: PDCD5 Antibody [NBP1-76991] - Analysis of PDCD5 in Jurkat cell lysate with PDCD5 antibody at 2.5 ug/mL.

Immunocytochemistry/Immunofluorescence: PDCD5 Antibody [NBP1-76991] - Jurkat cells with PDCD5 antibody at 5 ug/ml.

• Reactivity: Hu, Mu, Rt, Bv
• Applications: WB, ELISA, ICC/IF
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

PDCD5 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit PDCD5 Antibody - BSA Free (NBP1-76991) is a polyclonal antibody validated for use in WB, ELISA and ICC/IF. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Antibody was raised against a 13 amino acid synthetic peptide from near the amino terminus of human PDCD5. The immunogen is located within the first 50 amino acids of PDCD5. Amino Acid Squence: QEAKHREAEMRNS
• Predicted Species: Bovine (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PDCD5
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 5 ug/ml
  • Western Blot 2.5 ug/ml
• Theoretical MW: 21 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• Control Peptide:

  PDCD5 Peptide (NBP1-76991PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for PDCD5 Antibody - BSA Free

• FLJ42784
• MGC9294
• PD5
• PDCD5
• programmed cell death 5
• programmed cell death protein 5
• Protein TFAR19
• TF-1 cell apoptosis-related protein 19
• TFAR19 novel apoptosis-related
• TFAR19
• TFAR19TF1 cell apoptosis-related gene 19

Background

Programmed cell death 5 (PDCD5), a human apoptosis-related protein, is thought to play an early and universal role in apoptosis. PDCD5 is widely expressed and is upregulated in cells undergoing apoptosis, where it translocates rapidly from the cytoplasm to the nucleus. PDCD5 has a compact core structure of low flexibility with two mobile alpha-helices at N-terminal and a flexible unstructured C-terminal region. The charged residues are crucial for the ability of apoptosis-promoting and cell translocation of the protein. PDCD5 can facilitate apoptosis and enhance TAJ/TROY-induced paraptosis-like cell death. PDCD5 may play a dual role in the Tip60 pathway. It interacts with Tip60 and functions as a Tip60 co-activator to promote apoptosis. The nucleotide polymorphisms in the 5'-upstream region of PDCD5 affect promoter activity and the susceptibility of a Chinese population to develop chronic myelogenous leukemia and may represent a novel tumor suppressor gene influencing lung cancer.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PDCD5
• Uniprot:
  • O14737(Human)