TROY/TNFRSF19 Antibody [Unconjugated]

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB, IHC, ELISA(Cap)
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Catalog# & Conjugate Size Price
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Catalog# & Formulation Size Price

TROY/TNFRSF19 Antibody [Unconjugated] Summary

Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse TROY/TNFRSF19
Glu30-Leu170
Accession # Q9JLL3
Specificity
Detects mouse TROY/TNFRSF19 in ELISAs and Western blots. In sandwich immunoassays, less than 2% cross-reactivity with recombinant human TAJ is observed and less than 0.2% cross-reactivity with recombinant mouse (rm) EDAR, rmCD27, rmFas, rmRANK, rmTNF RI, and rmTNF RII is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
TNFRSF19
Purity Statement
Antigen Affinity-purified
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA Capture (Matched Antibody Pair) 0.2-0.8 ug/mL
  • ELISA Detection (Matched Antibody Pair) 0.1-0.4 ug/mL
  • ELISA Standard (Matched Pair)
  • Immunohistochemistry 5-15 ug/mL
  • Western Blot 0.1 ug/mL
Application Notes
Standard: Recombinant Mouse TROY/TNFRSF19 Fc Chimera (Catalog # 723-TR)
Publications
Read Publication using
AF723 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TROY/TNFRSF19 Antibody [Unconjugated]

  • TAJ
  • TAJ-alpha
  • TAJToxicity and JNK inducer
  • TNFRSF19
  • TRADE
  • TROY
  • TROYtumor necrosis factor receptor superfamily member 19
  • tumor necrosis factor receptor superfamily, member 19

Background

TROY, also named Toxicity and JNK inducer (TAJ) and TNFRSF19, is a novel member of the tumor necrosis factor receptor superfamily. The protein putatively encoded by the TROY mRNA is a 416 amino acid (aa) residue type I membrane protein with a 29 aa signal peptide, a 141 aa extracellular domain, a 23 aa transmembrane domain and a 223 aa cytoplasmic domain. Splice variants of mouse TROY (lacking the transmembrane and cytoplasmic domains or with only a 21 aa cytoplasmic tail), have also been identified. Like other members of the TNFRSF, TROY contains characteristic cysteine-rich motifs in the extracellular domain. The cytoplasmic domain of TROY does not have the death domain present in some TNFRSF members, but does contain a major TRAF2 (tumor necrosis factor
receptor‑associated factor 2)-binding consensus sequence. Mouse TROY shares 92% aa sequence identity with human TROY in their extracellular domains. The two proteins also have 57% homology in their cytoplasmic tails. Among TNFRSF members, TROY is most related to Edar, sharing 33% identity in the extracellular domain. Over‑expression of TROY has been reported to activate nuclear factor NF kappa B and c-Jun N-terminal kinase (JNK) pathways. TROY mRNA is exclusively expressed in the epithelia of various tissues in mouse day 13.5 embryos. In neonatal mice, expression of TROY is predominantly in hair follicles and in neuron-like cells in the cerebrum.

  1. Kojima, T. et al. (2000) J. Biol. Chem. 275:20742.
  2. Eby, M.T. et al. (2000) J. Biol. Chem. 275:15336.
  3. Hu, S. et al. (1999) Genomics 62:103.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TROY/TNFRSF19 Antibody (AF723)(1)

We have publications tested in 1 confirmed species: Rat.

We have publications tested in 1 application: Western Blot.


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Western Blot
(1)
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Secondary Antibodies

 

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Other Available Formats

Biotin BAF723

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Bioinformatics

Gene Symbol TNFRSF19
Uniprot