PAUF/ZG16B Antibody (817310) [Alexa Fluor® 488]

• Reactivity: Hu
• Applications: WB, IHC
• Clone: 817310
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 488

PAUF/ZG16B Antibody (817310) [Alexa Fluor® 488] Summary

• Immunogen: E. coli-derived recombinant human PAUF/ZG16B
  Gly53-Arg208
  Accession # Q96DA0
• Specificity: Detects human PAUF/ZG16B in direct ELISAs and Western blots.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for PAUF/ZG16B Antibody (817310) [Alexa Fluor® 488]

• DKFZp762P2216
• EC 3.1.2
• EC 3.4.19.12
• EECP
• HRPE773
• hTrabid
• JCLN2
• LOC124220
• PAUF
• PRO1567
• TRABIDubiquitin thioesterase ZRANB1
• TRAF-binding protein domain
• ZG16B
• Zinc finger Ran-binding domain-containing protein 1
• zinc finger, RAN-binding domain containing 1

Background

PAUF (pancreatic adenocarcinoma upregulated factor), gene name ZG16B (zymogen granule protein 16B), is a 156 amino acid, approximately 20-25 kDa secreted protein that is a member of the jacalin-binding lectin family. PAUF expression is thought to be restricted to primates, but the related ZG16P, which shares approximately 25% amino acid sequence identity, is more widely expressed. Human PAUF is overexpressed in pancreatic adenocarcinoma, binds Toll-like receptors TLR2 and TLR4, and inhibits CXCR4-dependent, TLR2-mediated NF-kB activation. It facilitates tumor growth, adhesiveness, and production of pro-tumorigenic cytokines.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.