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HAF018). A specific band was detected for PAUF/ZG16B at approximately 22 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_lightbox" target="_blank">
CTS013). Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm and plasma membranes of cancer cells. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections." class="big_lightbox" target="_blank">
PAUF (pancreatic adenocarcinoma upregulated factor), gene name ZG16B (zymogen granule protein 16B), is a 156 amino acid, approximately 20-25 kDa secreted protein that is a member of the jacalin-binding lectin family. PAUF expression is thought to be restricted to primates, but the related ZG16P, which shares approximately 25% amino acid sequence identity, is more widely expressed. Human PAUF is overexpressed in pancreatic adenocarcinoma, binds Toll-like receptors TLR2 and TLR4, and inhibits CXCR4-dependent, TLR2-mediated NF-kB activation. It facilitates tumor growth, adhesiveness, and production of pro-tumorigenic cytokines.
![Western Blot PAUF/ZG16B Antibody (817310) [Unconjugated]](http://images.novusbio.com/images/antibody/PAUF_MAB7777_Western_Blot_12713.jpg)
![Immunohistochemistry PAUF/ZG16B Antibody (817310) [Unconjugated]](http://images.novusbio.com/images/antibody/PAUF_MAB7777_Immunohistochemistry_12735.jpg)
![Western Blot PAUF/ZG16B Antibody (817310) [Unconjugated]](http://images.novusbio.com/fullsize/mab7777_human-pauf-zg16b-mab-clone-817310-western-blot-121220259311220.jpg)
