Patched 1/PTCH Antibody [DyLight 550]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 550

Patched 1/PTCH Antibody [DyLight 550] Summary

Immunogen
A genomic peptide made to a C-terminal region of the human Patched 1 protein (within residues 1200-1350). [Swiss-Prot Q13635]
Localization
Membrane, Cytoplasm
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PTCH1
Purity
Immunogen affinity purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
This Patched 1 antibody is useful in Western blot, where a band is seen ~161 kDa.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Patched 1/PTCH Antibody [DyLight 550]

  • BCNS
  • BCNSFLJ42602
  • FLJ26746
  • HPE7
  • mes
  • NBCCS
  • patched (Drosophila) homolog
  • Patched 1
  • patched homolog (Drosophila)
  • patched homolog 1 (Drosophila)
  • patched homolog 1
  • protein patched homolog 1
  • PTC
  • ptc1
  • PTCH protein +12b
  • PTCH protein +4'
  • PTCH protein -10
  • PTCH
  • PTCH1
  • PTCH11

Background

A Sonic Hedgehog receptor, Patched1 is a polytopic receptor protein that is essential for growth and differentiation. It has been implicated in making an impact in the variation in tumor and response to therapy in ovarian cancer. Patched1 activates Smoothened (SMO) constitutively in cells; in Gorlin syndrome patients, blocking this interaction is a very effective way to cease formation of basal cell neoplasia. In addition to its availability in cell membrane fractions, Patched1 C-terminal fragments also function as a signal transducer to the cell nucleus. In inflammatory processes like ischemia-reperfusion injury, Patched1 is upregulated and can be seen in histologically damaged areas. In the common pediatric tumor medulloblastoma, Patched1 is an indicator of susceptibility.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Patched 1/PTCH Antibody (NBP1-71662R) (0)

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for Patched 1/PTCH Antibody (NBP1-71662R). (Showing 1 - 1 of 1 FAQ).

  1. I need a proven anti-human Ptch1 antibody that maps C-terminus of Ptch1 protein which is thus appropriate for all isoforms of human Ptch1 protein. Can you please suggest any which can be used for Western blotting?
    • NB100-41101 is expected to recognize all isoforms. NBP2-19705, NBP1-71662, 21130002, and NBP1-59455 should all suit your needs as well. Further details about each product can be found on their individual datasheets.

Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for Patched 1/PTCH Antibody (NBP1-71662R)

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Diseases for Patched 1/PTCH Antibody (NBP1-71662R)

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Pathways for Patched 1/PTCH Antibody (NBP1-71662R)

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PTMs for Patched 1/PTCH Antibody (NBP1-71662R)

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Bioinformatics

Gene Symbol PTCH1
Entrez