Patched 1/PTCH Antibody [FITC]

Images

 
There are currently no images for Patched 1/PTCH Antibody (NBP1-71662F).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
FITC

Patched 1/PTCH Antibody [FITC] Summary

Immunogen
A genomic peptide made to a C-terminal region of the human Patched 1 protein (within residues 1200-1350). [Swiss-Prot Q13635]
Localization
Membrane, Cytoplasm
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PTCH1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
This Patched 1 antibody is useful in Western blot, where a band is seen ~161 kDa.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Patched 1/PTCH Antibody [FITC]

  • BCNS
  • BCNSFLJ42602
  • FLJ26746
  • HPE7
  • mes
  • NBCCS
  • patched (Drosophila) homolog
  • Patched 1
  • patched homolog (Drosophila)
  • patched homolog 1 (Drosophila)
  • patched homolog 1
  • protein patched homolog 1
  • PTC
  • ptc1
  • PTCH protein +12b
  • PTCH protein +4'
  • PTCH protein -10
  • PTCH
  • PTCH1
  • PTCH11

Background

Patched 1 (PTCH1) acts as a receptor for SHH, IHH (indian hedgehog) and DHH (desert hedgehog) in SHH/sonic hedgehog signaling pathway which is critical in embryonic development, tissue patterning, and cell-fate decisions. SHH pathway activation is triggered by binding of SHH to PTCH1 (glycosylation being necessary for binding), which in the absence of SHH suppresses the activity of SMO (Smoothened protein), and this SHH- PTCH1 binding or mutational inactivation of PTCH1 relieves the inhibition of SMO culminating in the activation of one or more of GLI1 transcription factors that regulate the expression of downstream targets. PTCH1 mutations or its aberrant expression may leads to developmental defects and a cancer-prone phenotype. Mice partially deficient in functional PTCH1 exhibit developmental abnormalities that are comparable to those of nevoid basal cell carcinoma syndrome patients and additionally, these mice develop tumors such as medulloblastomas, rhabdomyosarcomas, and basal cell carcinomas following UV or ionizing radiation exposure. PTCH1 germline mutations in humans are responsible for nevoid basal cell carcinoma syndrome, also called Gorlin syndrome characterized by various developmental malformations and a high predisposition to skin basal cell carcinoma. Besides basal cell nevus syndrome (BCNS), defects in PTCH1 have been linked to sporadic basal cell carcinoma (BCC) and holoprosencephaly type 7 (HPE7).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

NB600-600
Species: Hu, Mu
Applications: WB, ChIP, ELISA, IHC, IHC-P, Flow-IC
NBP1-57016
Species: Hu
Applications: WB
H00003077-M01
Species: Hu
Applications: WB, ELISA, ICC/IF
NBP2-24543
Species: Hu, Mu, Pm
Applications: WB, IHC-P
NBP1-89942
Species: Hu, Mu, Rt
Applications: WB, Simple Western, IHC, IHC-P
NBP2-55775
Species: Hu
Applications: WB, ICC/IF
NBP2-24543
Species: Hu, Mu, Pm
Applications: WB, IHC-P
H00008031-M04
Species: Hu, Mu
Applications: WB, ELISA, ICC/IF
1705-HH/CF
Species: Hu, Mu
NB200-103
Species: Hu, Mu, Rt, Ye, Xp(-)
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, CyTOF-ready, Flow-IC
NBP2-34294
Species: Hu, Mu, Rt
Applications: WB, Flow, IHC-P
AF4078
Species: Hu
Applications: WB, IHC, CyTOF-ready, ICFlow
NBP2-23602
Species: Hu, Mu, Rt
Applications: ICC/IF, IHC, IHC-Fr, IHC-P
AF175
Species: Hu
Applications: WB, Flow, IHC, CyTOF-ready, Neut
AF3690
Species: Hu, Mu
Applications: WB, ChIP, ICC

Publications for Patched 1/PTCH Antibody (NBP1-71662F) (0)

There are no publications for Patched 1/PTCH Antibody (NBP1-71662F).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for Patched 1/PTCH Antibody (NBP1-71662F) (0)

There are no reviews for Patched 1/PTCH Antibody (NBP1-71662F). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for Patched 1/PTCH Antibody (NBP1-71662F). (Showing 1 - 1 of 1 FAQ).

  1. I need a proven anti-human Ptch1 antibody that maps C-terminus of Ptch1 protein which is thus appropriate for all isoforms of human Ptch1 protein. Can you please suggest any which can be used for Western blotting?
    • NB100-41101 is expected to recognize all isoforms. NBP2-19705, NBP1-71662, 21130002, and NBP1-59455 should all suit your needs as well. Further details about each product can be found on their individual datasheets.

Secondary Antibodies

 

Isotype Controls

Additional Patched 1/PTCH Products

Bioinformatics Tool for Patched 1/PTCH Antibody (NBP1-71662F)

Discover related pathways, diseases and genes to Patched 1/PTCH Antibody (NBP1-71662F). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for Patched 1/PTCH Antibody (NBP1-71662F)

Discover more about diseases related to Patched 1/PTCH Antibody (NBP1-71662F).
 

Pathways for Patched 1/PTCH Antibody (NBP1-71662F)

View related products by pathway.

PTMs for Patched 1/PTCH Antibody (NBP1-71662F)

Learn more about PTMs related to Patched 1/PTCH Antibody (NBP1-71662F).
 

Research Areas for Patched 1/PTCH Antibody (NBP1-71662F)

Find related products by research area.

Blogs on Patched 1/PTCH

There are no specific blogs for Patched 1/PTCH, but you can read our latest blog posts.

Customers Who Bought This Also Bought

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our Patched 1/PTCH Antibody [FITC] and receive a gift card or discount.

Bioinformatics

Gene Symbol PTCH1
Entrez