Western Blot: PARP10 Antibody [NB100-2157] - Detection of Human PARP10 on HeLa whole cell lysate using NB100-2157. PARP10 was also immunoprecipitated using other rabbit anti-PARP10 antibodies.
Immunohistochemistry: PARP10 Antibody [NB100-2157] - Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti- PARP10 used at a dilution of 1:1,000 (1ug/ml). Detection: DAB
PARP10 is a member of the poly(ADP-ribose) polymerase (PARP) family involved in a variety of processes which includes DNA metabolism, the DNA damage response, transcription and the maintenance of genomic stability. Although each member of the PARP family exhibits poly(ADP-ribose) polymerase activity which catalyzes the attachment of ADP-ribose units from NAD+ to substrate proteins, the endogenous substrates of many of the family members, including PARP10, remain to be identified. Recent studies have shown that PARP10 is localized to the nucleoli and associates with RNA polymerase II. PARP10 is a substrate of and is activated by CDK2 and may serve an important function in cell proliferation. Alternate names for PARP10 include poly(ADP-ribose) polymerase 10, PARP-10, and FLJ14464.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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