PAR1/Thrombin Receptor Antibody (N2-11) [DyLight 488]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-P
Clone
N2-11
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 488

PAR1/Thrombin Receptor Antibody (N2-11) [DyLight 488] Summary

Immunogen
The oligopeptide CNATLDPRSFLL from human Thrombin Receptor. [Swiss-Prot# P25116]
Localization
Cell membrane; Multi-pass membrane protein.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
F2R
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • ELISA
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
This Thrombin Receptor (N2-11) antibody is useful for ELISA, Immunohistochemistry on paraffin-embedded sections, Immunocytochemistry/Immunofluorescence and Western blot, where a band can be seen at ~52 kDa.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
52 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human and mouse.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for PAR1/Thrombin Receptor Antibody (N2-11) [DyLight 488]

  • Cf2r
  • CF2RHTR
  • coagulation factor II (thrombin) receptor
  • Coagulation factor II receptor
  • F2R
  • HTR
  • PAR1
  • PAR1PAR-1protease-activated receptor 1
  • Protease-Activated Receptor 1
  • Thrombin receptor
  • ThrR
  • TRGPC
  • TRproteinase-activated receptor 1

Background

Thrombin Receptor, also known as Protease activated receptor 1 (PAR1), is a G-protein-coupled receptor that is highly expressed in invasive cancers. While Thrombin Receptor is known to have important functions in wound healing, by inducing human platelet recruitment to form stable blood clots for vascular injury, its misregulation seems to be intrinsically linked to the formation of invasive and deadly cancers. Thrombin Receptor is important in the cell invasion of cutaneous malignant melanoma, along with its partner KLK6. In lung cancer, Thrombin Receptor migration pairs with ERK1/2 activity to induce cell migration and tumor growth. Thrombin Receptor is known to interact with FAK, which alters endothelial barriers which normally would inhibit cell proliferation across boundaries. It is probably through this relationship that many metastatic effects associated with Thrombin Receptor are compounded. Thrombin Receptor normally functions to assist with healing, particularly in vasculature, but when it is not appropriately regulated, it can catalyze cancer growth and metastasis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Biotin Labeled NBP1-71770B
DyLight 350 Labeled NBP1-71770UV
DyLight 405 Labeled NBP1-71770V
DyLight 550 Labeled NBP1-71770R
DyLight 650 Labeled NBP1-71770C
DyLight 680 Labeled NBP1-71770FR
DyLight 755 Labeled NBP1-71770IR
FITC Labeled NBP1-71770F
HRP Labeled NBP1-71770H

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Bioinformatics

Gene Symbol F2R
Entrez