Pappalysin-1/PAPP-A Antibody (3C8)


Western Blot: PAPP A Antibody (3C8) [NB200-403] - Figure A - SDS-PAGE analysis in reducing conditions of human recombinant dPAPP-A and tissue (purified from atherosclerotic plaques) dPAPP-A. Lane 1: human htPAPP-A more
Western Blot: PAPP A Antibody (3C8) [NB200-403] - Detection of human PAPP-A and proMBP subunits of htPAPP-A by monoclonal antibodies in Western blotting. Lane 1: 18A10 (NB100-73059) Lane 2: 7A6 (NB100-73060) Lane 3: more
Sandwich ELISA: PAPP A Antibody (3C8) [NB200-403] - Calibration curves for PAPP-A sanwich immunoassay. (A) 4G11 3C8 Capture Mab: 4G11 (biotinylated) Detection MAbs: 3C8 (labeled with stable Eu3+ -chelate) Antigen: more

Product Details

Reactivity HuSpecies Glossary
Applications WB, ELISA, IP
Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Pappalysin-1/PAPP-A Antibody (3C8) Summary

Purified human PAPPA antigen.
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Store at 4C. Do not freeze.
PBS [pH 7.4]
0.09% Sodium Azide
Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.
Protein A purified


Application Notes
This antibody works well in htPAPP-A and dPAPP-A (PAPP-A dimer) immunoassays, Immunoprecipitation and PAPP-A immunodetection in Western blotting. Recommended pair for the detection of dPAPP-A antigen in blood of AMI patients and patients with unstable angina (capture - detection): NB200-401 (Capture) - NB200-403 (Detection). Best pair for the detection of htPAPP-A antigen in pregnancy serum (capture - detection): NB200-401(Capture) - NB200-403 (Detection)

Reactivity Notes

Cross-reacts with Human. Not yet tested in other species.

Alternate Names for Pappalysin-1/PAPP-A Antibody (3C8)

  • DIPLA1
  • EC
  • IGFBP-4ase
  • IGFBP-4aseaspecific BCL2 ARE-binding protein 2
  • IGF-dependent IGFBP-4 protease
  • insulin-like growth factor-dependent IGF binding protein-4 protease
  • Insulin-like growth factor-dependent IGF-binding protein 4 protease
  • PAPA
  • PAPPA1
  • PAPP-A1
  • PAPP-Adifferentially placenta 1 expressed protein
  • Pappalysin1
  • pappalysin-1
  • pregnacy-associated plasma protein A
  • Pregnancy-associated plasma protein A
  • pregnancy-associated plasma protein A, pappalysin 1


PAPP A was originally isolated from pregnancy serum as heterotetrameric protein complex with molecular weight approximately 500 kDa, consisting of two PAPP A subunits disulfide-linked with two subunits of the proform of eosinophil major basic protein (proMBP). In such a complex proMBP functions as an inhibitor of PAPP A proteinase activity. PAPP A is widely used as a marker of some pathologies during pregnancy. Reduced level of PAPP A in pregnancy blood in the first trimester is associated with fetal Down syndrome. PAPP A is considered as one of the best biochemical markers in early pregnancy used to screen for Down syndrome during the first trimester (Wald, N. J. et al).


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

Species: Hu, Mu
Applications: WB, Simple Western, ICC, ICFlow
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Species: Hu
Applications: IHC, IHC-P
Species: Hu
Applications: WB, IHC
Species: Hu
Applications: WB
Species: Hu
Applications: WB, IHC
Species: Hu
Applications: WB, IHC
Species: Hu, Mu
Applications: WB, ChIP, ICC/IF, IHC, IHC-P, IP
Species: Hu
Applications: WB, IHC, IHC-P, IF
Species: Hu
Applications: WB, ELISA, IHC, IHC-P

Publications for Pappalysin-1/PAPP-A Antibody (NB200-403) (0)

There are no publications for Pappalysin-1/PAPP-A Antibody (NB200-403).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for Pappalysin-1/PAPP-A Antibody (NB200-403) (0)

There are no reviews for Pappalysin-1/PAPP-A Antibody (NB200-403). By submitting a review earn points towards our Rewards Program.
  • 250 points for product review
  • 500 additional points for an image with your product review
  • Double points (500) if you are the first to review this product
  • Double points (1000) if you are the first to review this product with an image

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for Pappalysin-1/PAPP-A Antibody (NB200-403). (Showing 1 - 1 of 1 FAQ).

  1. I am highly interested to use couple of Anti-PAPP-A antibodies from your reputed companies for my research work. I have got the information regarding the immunogen used to generate these antibodies, however could not get any information regarding the specific amino acids/epitope to which your Anti-PAPP-A Antibodies binds with the antigen (PAPP-A).
    • Unfortunately, none of our PAPP A antibodies have been epitope mapped. Many of them have also been generated against full-length PAPP A, so there are many potential binding sites.

Secondary Antibodies


Isotype Controls

Additional Pappalysin-1/PAPP-A Antibody (3C8) Products

Related Products by Gene

Bioinformatics Tool for Pappalysin-1/PAPP-A Antibody (NB200-403)

Discover related pathways, diseases and genes to Pappalysin-1/PAPP-A Antibody (NB200-403). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for Pappalysin-1/PAPP-A Antibody (NB200-403)

Discover more about diseases related to Pappalysin-1/PAPP-A Antibody (NB200-403).

Pathways for Pappalysin-1/PAPP-A Antibody (NB200-403)

View related products by pathway.

PTMs for Pappalysin-1/PAPP-A Antibody (NB200-403)

Learn more about PTMs related to Pappalysin-1/PAPP-A Antibody (NB200-403).

Research Areas for Pappalysin-1/PAPP-A Antibody (NB200-403)

Find related products by research area.

Blogs on Pappalysin-1/PAPP-A

There are no specific blogs for Pappalysin-1/PAPP-A, but you can read our latest blog posts.

Contact Information

Product PDFs


Gene Symbol PAPPA

Customer Resources

Novus Review - Submit your review and earn rewards points which can be used for merchandise & discounts.
Risk Free Testing - Test on a species/application not listed above to receive a full credit towards a future purchase.

Novus' Quality Guarantee - Novus guarantees that every product we sell will work in the application and species listed on our website and datasheets.

Submit your question on NB200-403 below.
During business hours, we will respond to your email within 24 hours. For any questions submitted on the weekend, a response will be received on Monday.
For immediate assistance during business hours M- F (excluding major holidays), please contact us.
Ask a Scientist - We have a lab full of white coats just waiting for your scientific questions and concerns.

Customers Who Bought This Also Bought