Pappalysin-1/PAPP-A Products

Antibodies
Pappalysin-1/PAPP-A Antibody ...
Pappalysin-1/PAPP-A Antibody [Unco...
AF2487
Species: Hu
Applications: WB, IP
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
ELISA Kits
Pappalysin-1/PAPP-A ELISA Kit ...
Pappalysin-1/PAPP-A ELISA Kit [HRP]
KA1281
Species: Hu
Proteins
Pappalysin-1/PAPP-A Partial R ...
Pappalysin-1/PAPP-A Partial Recomb...
H00005069-Q01
Species: Hu
Applications: WB, ELISA, PA
Pappalysin-1/PAPP-A Recombina ...
Pappalysin-1/PAPP-A Recombinant Pr...
NBP1-90087PEP
Species: Hu
Applications: AC
RNAi
Pappalysin-1/PAPP-A RNAi
Pappalysin-1/PAPP-A RNAi
H00005069-R01
Species: Hu

Description

PAPP A was originally isolated from pregnancy serum as heterotetrameric protein complex with molecular weight approximately 500 kDa, consisting of two PAPP A subunits disulfide-linked with two subunits of the proform of eosinophil major basic protein (proMBP). In such a complex proMBP functions as an inhibitor of PAPP A proteinase activity. PAPP A is widely used as a marker of some pathologies during pregnancy. Reduced level of PAPP A in pregnancy blood in the first trimester is associated with fetal Down syndrome. PAPP A is considered as one of the best biochemical markers in early pregnancy used to screen for Down syndrome during the first trimester (Wald, N. J. et al).

Bioinformatics

Uniprot Human
Human
Human
Product By Gene ID 5069
Alternate Names
  • Pregnancy-associated plasma protein A
  • Insulin-like growth factor-dependent IGF-binding protein 4 protease
  • EC 3.4.24.79
  • PAPPA1
  • pregnacy-associated plasma protein A
  • PAPA
  • pappalysin-1
  • DIPLA1
  • insulin-like growth factor-dependent IGF binding protein-4 protease
  • ASBABP2
  • PAPP-Adifferentially placenta 1 expressed protein
  • IGFBP-4aseaspecific BCL2 ARE-binding protein 2
  • IGF-dependent IGFBP-4 protease
  • pregnancy-associated plasma protein A, pappalysin 1

Research Areas for Pappalysin-1/PAPP-A

Find related products by research area and learn more about each of the different research areas below.

Cancer

PTMs for Pappalysin-1/PAPP-A

Learn more about PTMs related to Pappalysin-1/PAPP-A.

Cleavage
Phosphorylation
Glycosylation

Bioinformatics Tool for Pappalysin-1/PAPP-A

Discover related pathways, diseases and genes to Pappalysin-1/PAPP-A. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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