PAK1/2/3 [p Thr423, p Thr402, p Thr421] Antibody

Images

 
Immunocytochemistry/ Immunofluorescence: PAK1/2/3 [p Thr423, p Thr402, p Thr421] Antibody [NB100-82131] - Staining of methanol-fixed Hela cells using PAK1/PAK2/PAK3(Phospho-Thr423/Thr402/Thr421) antibody
Immunohistochemistry: PAK1/2/3 [p Thr423, p Thr402, p Thr421] Antibody [NB100-82131] - Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using PAK1/PAK2/PAK3 (Phospho-Thr423/Thr402/Thr421) ...read more

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-Fr, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

PAK1/2/3 [p Thr423, p Thr402, p Thr421] Antibody Summary

Immunogen
The antiserum was produced against synthesized phosphopeptide derived from Human PAK1/2/3 around the phosphorylation site of threonine 423/402/421 (R-S-TP-M-V).
Modification
p Thr423, p Thr402, p Thr421
Specificity
Detects endogenous levels of PAK1/2/3 only when phosphorylated at threonine 423/402/421.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PAK1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence 1:100-1:200
  • Immunohistochemistry 1:50-1:100
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
Use in Western blot reported in scientific literature (PMID 26821597). Use in Immunohistochemistry-Frozen reported in scientific literature (PMID: 29066727).
Publications
Read Publications using
NB100-82131 in the following applications:

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
Preservative
0.02% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for PAK1/2/3 [p Thr423, p Thr402, p Thr421] Antibody

  • alpha-PAK
  • EC 2.7.11
  • EC 2.7.11.1
  • MGC130000
  • MGC130001
  • p21 protein (Cdc42/Rac)-activated kinase 1
  • p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)
  • p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)
  • p21-activated kinase 1
  • p65-PAK
  • PAK-1
  • PAKalpha
  • serine/threonine-protein kinase PAK 1
  • STE20 homolog, yeast

Background

In mammals, there are several identified isoforms of p21 Activated Protein Kinases or PAKs: PAK1 and PAK3 are mostly brain specific, while PAK2 is expressed ubiquitously. Mutations of the gene coding for PAK3 are associated with X linked mental retardation and PAK3 is a key regulator of synapse formation and plasticity in the hippocampus. PAK3 is thought to play a key role in regulation of cell shape and motility as well as cell death.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for PAK1/2/3 Antibody (NB100-82131)(2)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: IHC-Fr, WB.


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WB
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Array NB100-82131

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Bioinformatics

Gene Symbol PAK1
Entrez
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