PAK1/2/3 Products

Description

In mammals, there are several identified isoforms of p21-activated Protein Kinases or PAKs: alpha-PAK (also known as PAK-1) and beta-PAK (also known as PAK-3) are mostly brain-specific, while gamma-PAK (also known as PAK-2) is expressed ubiquitously. Mutations of the gene coding for PAK-3 are associated with X-linked mental retardation and recent work indicates that PAK-3 is a key regulator of synapse formation and plasticity in the hippocampus. PAK-3 is thought to play a key role in regulation of cell shape and motility as well as cell death. Autophosphorylation of Thr402 in the protein has been found to be essential for activation of PAK. (1-4)

Bioinformatics

Uniprot	P35465 Rat Q13153 Human
Product By Gene ID	5058
Alternate Names	Alpha-PAK alpha-PAK EC 2.7.11 EC 2.7.11.1 MGC130000 MGC130001 p21 protein (Cdc42/Rac)-activated kinase 1 p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related) p21-activated kinase 1 p65-PAK PAK-1 PAKalpha serine/threonine-protein kinase PAK 1 STE20 homolog, yeast

Research Areas for PAK1/2/3

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Breast Cancer
Cancer
Neuroscience
Phospho-Specific
Signal Transduction