PAK1/2/3 Products

PAK1/2/3 [p Thr423, p Thr402, ...
PAK1/2/3 [p Thr423, p Thr402, p Th...
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P
Host: Rabbit Polyclonal
PAK1/2/3 [p Thr402] Antibody
PAK1/2/3 [p Thr402] Antibody
Species: Hu, Mu, Rt, Bv, Ca
Applications: WB
Host: Rabbit Polyclonal


In mammals, there are several identified isoforms of p21-activated Protein Kinases or PAKs: alpha-PAK (also known as PAK-1) and beta-PAK (also known as PAK-3) are mostly brain-specific, while gamma-PAK (also known as PAK-2) is expressed ubiquitously. Mutations of the gene coding for PAK-3 are associated with X-linked mental retardation and recent work indicates that PAK-3 is a key regulator of synapse formation and plasticity in the hippocampus. PAK-3 is thought to play a key role in regulation of cell shape and motility as well as cell death. Autophosphorylation of Thr402 in the protein has been found to be essential for activation of PAK. (1-4)


Uniprot Human
Product By Gene ID 5058
Alternate Names
  • MGC130000
  • EC 2.7.11
  • EC
  • Alpha-PAK
  • p65-PAK
  • STE20 homolog, yeast
  • p21-activated kinase 1
  • serine/threonine-protein kinase PAK 1
  • PAK-1
  • alpha-PAK
  • p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)
  • PAKalpha
  • p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)
  • MGC130001
  • p21 protein (Cdc42/Rac)-activated kinase 1

Research Areas for PAK1/2/3

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Breast Cancer
Signal Transduction

Bioinformatics Tool for PAK1/2/3

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