Osteoprotegerin/TNFRSF11B Antibody (98A1071) - BSA Free


Immunohistochemistry-Paraffin: Osteoprotegerin/TNFRSF11B Antibody (98A1071) [NB100-56505] - Human liver using 1:200 dilution of anti-Osteoprotegerin/TNFRSF11B antibody (clone 98A1071). The staining was developed with ...read more
Western Blot: Osteoprotegerin/TNFRSF11B Antibody (98A1071) [NB100-56505] - Total protein from human MG63 and Daudi cell lines was separated on a 7.5% gel by SDS-PAGE, transferred to PVDF membrane and blocked in 5% ...read more
Immunocytochemistry/ Immunofluorescence: Osteoprotegerin/TNFRSF11B Antibody (98A1071) [NB100-56505] - MG-63 cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X PBS + 0.05% ...read more
Flow Cytometry: Osteoprotegerin/TNFRSF11B Antibody (98A1071) [NB100-56505] - Intracellular staining of 10^6 HeLa cells using 0.2 ug of OPG antibody, 0.5 ul of PE secondary.
Immunohistochemistry-Paraffin: Osteoprotegerin/TNFRSF11B Antibody (98A1071) [NB100-56505] - Human breast tissue stained with OPG antibody (5 ug/ml), peroxidase-conjugate and DAB chromogen.
Immunohistochemistry-Paraffin: Osteoprotegerin/TNFRSF11B Antibody (98A1071) [NB100-56505] - Staining of human liver. Tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Immunohistochemistry-Paraffin: Osteoprotegerin/TNFRSF11B Antibody (98A1071) [NB100-56505] - Staining of human heart tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

Product Details

Reactivity Hu, Mu, Rt, RbSpecies Glossary
Applications WB, ELISA, Flow, ICC/IF, IHC, IP, CyTOF-ready
BSA Free
1.0 mg/ml

Order Details

Osteoprotegerin/TNFRSF11B Antibody (98A1071) - BSA Free Summary

A peptide corresponding to the amino acids 20-37 TQETFPPKYLHYDEETSH of human Osteoprotegerin was used as immunogen for this antibody.
The Osteoprotegerin antibody, clone 98A1071, detects all forms of Osteoprotegerin including monomeric, dimeric and Osteoprotegerin bound to RANKL (Vandooren, 2008) as well as Osteoprotegerin bound to TRAIL (Sandra, 2006).
IgG1 Kappa
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • CyTOF-ready
  • ELISA reported in scientific literature (PMID 15935726)
  • Flow Cytometry 0.2-1 ug/1 million cells
  • Immunocytochemistry/Immunofluorescence 1:20-1:1000. Use reported in scientific literature (Sandra (2006))
  • Immunohistochemistry 1:100-1:1000
  • Immunohistochemistry-Frozen 1:20-1:1000. Use reported in scientific literature (Boumans (2012))
  • Immunohistochemistry-Paraffin 1:100-1:1000
  • Immunoprecipitation 1:20-1:1000. Use reported in scientific literature (Sandra (2006))
  • Western Blot 1 ug/ml
Application Notes
This antibody is CyTOF ready.
Read Publications using
NB100-56505 in the following applications:

Reactivity Notes

Rabbit reactivity reported in scientific literature (PMID: 31658685).

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.05% Sodium Azide
1.0 mg/ml
Protein G purified

Alternate Names for Osteoprotegerin/TNFRSF11B Antibody (98A1071) - BSA Free

  • OCIF
  • OCIFMGC29565
  • OPG
  • OPGtumor necrosis factor receptor superfamily member 11B
  • Osteoclastogenesis inhibitory factor
  • Osteoprotegerin
  • TR1
  • tumor necrosis factor receptor superfamily, member 11b


Osteoprotegerin (OPG) is a secretory glycoprotein belonging to TNF receptor (TNFR) superfamily. As the name implies, it protects bone. Unlike other TNFRs it lacks a transmembrane domain and lacks any apparent cell associated signals. OPG consists of 401 amino acid with molecular mass of approximately 55 kD as a monomer and 110 kD as a disulfide-linked dimer. High levels of OPG mRNA has been detected in lung, heart, kidney, and placenta1. Recombinant OPG blocks osteoclastogenesis in vitro and increases bone density in vivo. Targeted deletion of OPG in mice results in severe early-onset of osteoporosity. These mice also exhibit increase in vascular calcification in the aorta and renal arteries suggesting that it may also play a role in degenerative arterial disease.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Osteoprotegerin/TNFRSF11B Antibody (NB100-56505)(38)

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Rabbit.

We have publications tested in 6 applications: ELISA, ICC/IF, IF/IHC, IHC-Fr, IHC-P, WB.

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Showing Publications 1 - 10 of 38. Show All 38 Publications.
Publications using NB100-56505 Applications Species
Kumar K, Datta K, Fornace A, Suman S Total body proton and heavy-ion irradiation causes cellular senescence and promotes pro-osteoclastogenic activity in mouse bone marrow Heliyon 2022-01-01 [PMID: 35028468] (IHC-P, Mouse) IHC-P Mouse
Boumans MJ, Thurlings RM, Yeo L et al. Rituximab abrogates joint destruction in rheumatoid arthritis by inhibiting osteoclastogenesis. Ann Rheum Dis. 2012-01-01 [PMID: 22072013]
Sengun MC, Gunpinar S Effects of systemic hydroxytyrosol application in experimental periodontitis of rats International Journal of Plant Based PHARMACEUTICALS 2022-01-01 (IF/IHC, Rat) IF/IHC Rat
Lysitska A, Galanis N, Skandalos I Et al. Histology and Immunohistochemistry of Radial Arteries Are Suggestive of an Interaction between Calcification and Early Atherosclerotic Lesions in Chronic Kidney Disease Medicina 2021-10-24 [PMID: 34833374] (IHC-P, Human) IHC-P Human
Zhang Q, Chen T, Zhang Y, et al. MiR-30c-5p regulates adventitial progenitor cells differentiation to vascular smooth muscle cells through targeting OPG Stem Cell Research & Therapy 2021-12-01 [PMID: 33468212] (WB) WB
Jiang Y, Li J, Li G et al. Osteoprotegerin interacts with syndecan-1 to promote human endometrial stromal decidualization by decreasing Akt phosphorylation Hum Reprod 2020-11-01 [PMID: 33047116]
Bayer Alinca S, Saglam E, Zengin Celik T et al. Is low level laser therapy or ozone therapy more effective for bone healing? Understanding the mechanisms of HIF-1alpha, RANKL and OPG Biotech Histochem 2020-04-15 [PMID: 32292090]
Lee YC, Chan YH, Hsieh SC et al. Comparing the Osteogenic Potentials and Bone Regeneration Capacities of Bone Marrow and Dental Pulp Mesenchymal Stem Cells in a Rabbit Calvarial Bone Defect Model Int J Mol Sci 2019-10-10 [PMID: 31658685] (IF/IHC, Rabbit) IF/IHC Rabbit
Wang X, Cao Y, Liu Z et al. Alveolar Bone Density Reduction in Rats Caused by Unilateral Nasal Obstruction Balkan Med J 2019-10-28 [PMID: 31290639] (WB, Rat) WB Rat
Gegen T, Zhu Y, Sun QHou B Role of interleukin-33 in the clinical pathogenesis of chronic apical periodontitis J. Int. Med. Res. 2019-06-20 [PMID: 31218936] (IF/IHC, Human) IF/IHC Human
Show All 38 Publications.

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Product General Protocols

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Osteoprotegerin/TNFRSF11B Antibody (NB100-56505). (Showing 1 - 1 of 1 FAQs).

  1. Are the following monoclonals purified from ascites or from tissue culture supernatant?NB100-56541, NB100-56705, NB600-1298, NB100-56534, NB100-56505, NBP2-24873, NB600-1107, NBP2-24917, NB100-56524, NB100-56712
    • These antibodies are all purified from tissue culture supernatant.

Secondary Antibodies


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Gene Symbol TNFRSF11B