Optineurin Antibody (08) [Alexa Fluor™ Plus 680]

• Reactivity: Hu
• Applications: ELISA
• Clone: 08
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 680

Optineurin Antibody (08) [Alexa Fluor™ Plus 680] Summary

• Immunogen: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Optineurin (Accession#: NP_068815.2; Met1-Ile577).
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: OPTN
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A purified

Notes

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Optineurin Antibody (08) [Alexa Fluor™ Plus 680]

• ALS12
• FIP2
• FIP2FIP-2
• GLC1E
• GLC1Eglaucoma 1, open angle, E (adult-onset)
• HIP7
• HIP7ALS12
• Huntingtin interacting protein L
• Huntingtin yeast partner L
• Huntingtin-interacting protein 7
• Huntingtin-interacting protein L
• HYPL
• HYPLHIP-7
• NEMO-related protein
• NRP
• NRPE3-14.7K-interacting protein
• Optic neuropathy-inducing protein
• Optineurin
• OPTN
• TFIIIA-INTP
• Transcription factor IIIA-interacting protein
• transcrption factor IIIA-interacting protein
• tumor necrosis factor alpha-inducible cellular protein containing leucinezipper domains

Background

Optineurin encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: OPTN