Optineurin Products

Description

This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq]. Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Bioinformatics

Product By Gene ID

10133

Alternate Names

ALS12 FIP2 FIP2FIP-2 GLC1E GLC1Eglaucoma 1, open angle, E (adult-onset) HIP7 HIP7ALS12 Huntingtin interacting protein L Huntingtin yeast partner L Huntingtin-interacting protein 7 Huntingtin-interacting protein L HYPL HYPLHIP-7 NEMO-related protein NRP NRPE3-14.7K-interacting protein Optic neuropathy-inducing protein Optineurin OPTN TFIIIA-INTP Transcription factor IIIA-interacting protein transcrption factor IIIA-interacting protein tumor necrosis factor alpha-inducible cellular protein containing leucinezipper domains

Research Areas for Optineurin

Find related products by research area and learn more about each of the different research areas below.

Immunology
Innate Immunity
Vision