Olig2 Antibody [Unconjugated]

Olig2 and Oligodendrocyte Marker O4 were detected in 7 day differentiated rat cortical stem cells using 10 µg/mL Goat Anti-Human/Mouse/Rat Olig2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2418) and 10 µg/mL Goat Anti-Human/Mouse/Rat/Chicken O4 Monoclonal Antibody (Catalog # MAB1326). Cells were incubated with primary antibodies for 3 hours at room temperature. Cells were stained for Olig2 using the NorthernLights™ 637-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL002), and stained for O4 using an anti-mouse IgM secondary antibody (pseudo-stained green). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

A172 human glioblastoma cell line were fixed using formaldehyde, resuspended in lysis buffer, and sonicated to shear chromatin. Olig2/DNA complexes were immunoprecipitated using 5 μg Goat Anti-Human/Mouse/Rat Olig2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2418) or control antibody (Catalog # AB-108-C) for 15 minutes in an ultrasonic bath, followed by Biotinylated Anti-Goat IgG Secondary Antibody (Catalog # BAF109). Immunocomplexes were captured using 50 μL of MagCellect Streptavidin Ferrofluid (Catalog # MAG999) and DNA was purified using chelating resin solution. The p21 promoter was detected by standard PCR.

Olig2 was detected in immersion fixed frozen sections of mouse embryo (13 d.p.c.) using Goat Anti-Human/Mouse/Rat Olig2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2418) at 8 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Specific staining was localized to developing brain. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.

Olig2 was detected in immersion fixed paraffin-embedded sections of human brain (cortex) using Goat Anti-Human/Mouse/Rat Olig2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2418) at 10 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (VC004). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cell nuclei. Staining was performed using our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Olig2 was detected in immersion fixed paraffin-embedded sections of rat midbrain using Goat Anti-Human/Mouse/Rat Olig2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2418) at 10 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (VC004). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cell nuclei. Staining was performed using our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Pathological analysis of l2hgdh-/- mice.The figure compares the histological and ultrastructural appearance of the brain of l2hgdh+/+ (left panels: A, B, E, G, H, K, L) and l2hgdh-/- mice (right panels: C, D, F, I, J, M, N). Hematoxylin and eosin staining shows low-magnification of the lateral part of the brain (A, C) at the level of the lateral ventricle (LV), the caudate putamen (striatum; CPu) and the anterior commissure, anterior part (aca). Higher magnification of pencils of Wilson are shown in panels B and D. Notice the satellite oligodendrocyte at B (arrow). Luxol fast blue staining of myelin is shown in E and F, highlighting the predominant presence of vacuoles in the pencils of Wilson of the striatum of the l2hgdh-/- mouse. Panels G-J are microphotographs from the junction between cortex and white matter in the vicinity of corpus callosum. Immunostaining of NeuN (G and I) shows that most vacuoles in the l2hgdh-/- mice are at distance from the nucleus of neurons (notice the abundance of vacuoles in the lower part of panel I, devoid of neurons) although a few vacuoles indent the nucleus of some neurons (arrowheads). However, the nucleus of satellite oligodendrocytes is also present in close contact to the vacuole indenting the nucleus of some neurons (arrows), preventing to identify clearly which cell type actually contains the peri-neuronal vacuole. In contrast, immunostaining of Olig2 (H and J) clearly shows that most vacuoles are in close contact to the nucleus of oligodendrocytes in the l2hgdh-/- mouse brain. Notice the small size of the nucleus of oligodendrocytes compared to the nucleus of neurons. Panels K-N are Transmission Electron Microscopy photographs of striatum tissue. Ultrastructural analysis (K-N) shows many empty-looking cell processes (asterisks in panels M and N), containing dilated cytoplasmic organelles, in the glia of l2hgdh-/- mice. The myelin sheath of many axons appears focally altered or disrupted (arrows at M and N), sometimes at the vicinity of empty-looking spaces. C, capillary lumen. The length of the scale bar is indicated in each panel. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/25763823), licensed under a CC-BY license. Not internally tested by R&D Systems.

alpha -Syn PFF exposure to immature OLGs during differentiation-induced abnormal oligodendrogenesis. a Confocal images of oligodendroglial cells on day 4 after differentiation induction showing the colocalization of alpha -syn immunoreactivity and cleaved caspase-9 expression. The cells were incubated with 1 μM alpha -syn PFFs for 24 h (day 3–4) before fixation. White arrowheads indicate intracellular inclusions. The regions marked by dotted squares are highlighted in the magnified views. Scale bar = 5 μm. b Scheme showing the experimental protocols of 3 μM alpha -syn PFF exposure to oligodendroglial cells during two different phases (day 0–1, or day 3–4) of differentiation. c Cell viability analysis (WST assay) of day 8 OLGs, which were obtained through different protocols of alpha -syn PFF exposure during differentiation (no exposure, exposure on day 0–1, or exposure on days 3–4). N = 5, respectively, independent culture, Kruskal–Wallis, p* AF2418) at 3ug/mL with overnight incubation at 4 degrees Celsius followed by incubation with anti-goat IgG VisUCyte HRP Polymer Antibody (Catalog # VC004) and DAB chromogen (yellow-brown). Tissue was counterstained with hematoxylin (blue). Specific staining was localized to glial cells.

• Reactivity: Hu, Mu, Rt
• Applications: WB, IHC, ChIP, Dual ISH-IHC, ICC/IF
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: LYOPH

Olig2 Antibody [Unconjugated] Summary

• Immunogen: E. coli-derived recombinant human Olig2
  Met1-Lys323
  Accession # Q13516
• Specificity: Detects human Olig2 in direct ELISAs and Western blots.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: OLIG2
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Chromatin Immunoprecipitation (ChIP) 5 ug/5 x 10^6 cells
  • Dual RNAscope ISH-IHC 5-15 ug/mL
  • Immunocytochemistry 5-15 ug/mL
  • Immunohistochemistry 5-15 ug/mL
  • Western Blot 0.1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. See Certificate of Analysis for details.
  *Small pack size (-SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Olig2 Antibody [Unconjugated]

• BHLHB1
• BHLHE19
• Class B basic helix-loop-helix protein 1
• Class E basic helix-loop-helix protein 19
• human protein kinase C-binding protein RACK17
• Olig2
• OLIGO2
• oligodendrocyte lineage transcription factor 2
• oligodendrocyte transcription factor 2
• oligodendrocyte-specific bHLH transcription factor 2
• PRKCBP2
• protein kinase C binding protein 2
• Protein kinase C-binding protein 2
• Protein kinase C-binding protein RACK17
• RACK17
• RACK17helix-loop-helix protein, class B, 1

Background

Olig1 and Olig2 are basic-helix-loop-helix (bHLH) transcription factors expressed in the motor neuron progenitor (pMN) domain of the spinal cord that generates motor neurons and oligodendrocytes. Olig1 is involved in the development and maturation of oligodendrocytes. Olig2 is required for oligodendrocyte and motor neuron specification in the spinal cord.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Olig2 Antibody (AF2418)(204)

Publications using AF2418

• Balcomb, K;Johnston, C;Kavanagh, T;Leitner, D;Schneider, J;Halliday, G;Wisniewski, T;Sunde, M;Drummond, E; SMOC1 colocalizes with Alzheimer's disease neuropathology and delays A? aggregation Acta Neuropathologica 2024-11-25 [PMID: 39585417] (Immunohistochemistry, Human)
• Bernou, C;Mouthon, MA;Daynac, M;Kortulewski, T;Demaille, B;Barroca, V;Couillard-Despres, S;Dechamps, N;Ménard, V;Bellenger, L;Antoniewski, C;Chicheportiche, AD;Boussin, FD; Switching of RNA splicing regulators in immature neuroblasts during adult neurogenesis eLife 2024-11-22 [PMID: 39576691] (Immunocytochemistry, Mouse)
• Zhao, Q;Zhu, Y;Ren, Y;Zhao, L;Zhao, J;Yin, S;Ni, H;Zhu, R;Cheng, L;Xie, N; Targeting resident astrocytes attenuates neuropathic pain after spinal cord injury eLife 2024-11-15 [PMID: 39545839] (Immunohistochemistry, Mouse)
• Ruetz, TJ;Pogson, AN;Kashiwagi, CM;Gagnon, SD;Morton, B;Sun, ED;Na, J;Yeo, RW;Leeman, DS;Morgens, DW;Tsui, CK;Li, A;Bassik, MC;Brunet, A; CRISPR-Cas9 screens reveal regulators of ageing in neural stem cells Nature 2024-10-02 [PMID: 39358505] (Immunohistochemistry, Immunocytochemistry, Transgenic Mouse)
• Russo, M;Zahaf, A;Kassoussi, A;Sharif, A;Faure, H;Traiffort, E;Ruat, M; Sonic Hedgehog Is an Early Oligodendrocyte Marker During Remyelination Cells 2024-11-01 [PMID: 39513915] (Immunocytochemistry, Mouse)
• Jansen, MI;Musumeci, G;Castorina, A; Differential Expression of PACAP/VIP Receptors in the Post-Mortem CNS White Matter of Multiple Sclerosis Donors International journal of molecular sciences 2024-08-14 [PMID: 39201536] (Immunohistochemistry, Human)
• MacArthur, IC;Ma, L;Huang, CY;Bhavsar, H;Suzuki, M;Dawlaty, MM; Developmental DNA demethylation is a determinant of neural stem cell identity and gliogenic competence Science advances 2024-08-30 [PMID: 39196941] (Immunohistochemistry, Transgenic Mouse)
• Rosberg, R;Smolag, KI;Sjölund, J;Johansson, E;Bergelin, C;Wahldén, J;Pantazopoulou, V;Ceberg, C;Pietras, K;Blom, AM;Pietras, A; Hypoxia-induced complement component 3 promotes aggressive tumor growth in the glioblastoma microenvironment JCI insight 2024-08-22 [PMID: 39172519] (Immunohistochemistry, Mouse)
• Park, H;Song, J;Jeong, HW;Grönloh, MLB;Koh, BI;Bovay, E;Kim, KP;Klotz, L;Thistlethwaite, PA;van Buul, JD;Sorokin, L;Adams, RH; Apelin modulates inflammation and leukocyte recruitment in experimental autoimmune encephalomyelitis Nature communications 2024-07-25 [PMID: 39060233] (Immunohistochemistry, Mouse)
• Hawkins, S;Mondaini, A;Namboori, SC;Nguyen, GG;Yeo, GW;Javed, A;Bhinge, A; ePRINT: exonuclease assisted mapping of protein-RNA interactions Genome biology 2024-05-28 [PMID: 38807229] (Immunocytochemistry, Human)
• Drexler, R;Khatri, R;Sauvigny, T;Mohme, M;Maire, C;Ryba, A;Zghaibeh, Y;Dührsen, L;Salviano?Silva, A;Lamszus, K;Westphal, M;Gempt, J;Wefers, A;Neumann, J;Bode, H;Hausmann, F;Huber, T;Bonn, S;Jütten, K;Delev, D;Weber, K;Harter, P;Onken, J;Vajkoczy, P;Capper, D;Wiestler, B;Weller, M;Snijder, B;Buck, A;Wei beta , T;Göller, P;Sahm, F;Menstel, J;Zimmer, D;Keough, M;Ni, L;Monje, M;Silverbush, D;Hovestadt, V;Suvà, M;Krishna, S;Hervey?Jumper, S;Schüller, U;Heiland, D;Hänzelmann, S;Ricklefs, F; A prognostic neural epigenetic signature in high-grade glioma Nature medicine 2024-06-01 [PMID: 38760585] (Immunohistochemistry, Human)
• Ozkan, A;Padmanabhan, HK;Shipman, SL;Azim, E;Kumar, P;Sadegh, C;Basak, AN;Macklis, JD; Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors bioRxiv : the preprint server for biology 2024-04-23 [PMID: 38712174] (Immunocytochemistry, Transgenic Mouse)
• Bachmann, H;Vandemoortele, B;Vermeirssen, V;Carrette, E;Vonck, K;Boon, P;Raedt, R;Laureys, G; Vagus Nerve Stimulation enhances remyelination and decreases innate neuroinflammation in lysolecithin-induced demyelination Brain stimulation 2024-04-20 [PMID: 38648972] (Immunohistochemistry, Rat)
• Yang, TT;Liu, PJ;Sun, QY;Wang, ZY;Yuan, GB;Fan, ZX;Ma, L;Lu, JF;Yuan, BY;Zou, WL;Zhao, LM;Li, Q;Liu, GZ; CD4+CD25+ regulatory T cells ex vivo generated from autologous naïve CD4+ T cells suppress EAE progression Scientific reports 2024-03-15 [PMID: 38491084] (Immunohistochemistry, Mouse)
• Huuki-Myers, LA;Montgomery, KD;Kwon, SH;Cinquemani, S;Maden, SK;Eagles, NJ;Kleinman, JE;Hyde, TM;Hicks, SC;Maynard, KR;Collado-Torres, L; Benchmark of cellular deconvolution methods using a multi-assay reference dataset from postmortem human prefrontal cortex bioRxiv : the preprint server for biology 2024-02-12 [PMID: 38405805] (IHC, Human)
• Zhu, Q;Liang, P;Meng, H;Li, F;Miao, W;Chu, C;Wang, W;Li, D;Chen, C;Shi, Y;Yu, X;Ping, Y;Niu, C;Wu, HB;Zhang, A;Bian, XW;Zhou, W; Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells Nature communications 2024-01-02 [PMID: 38167292] (Immunohistochemistry, Human, Xenograft)
• Álvarez, I;Tirado-Herranz, A;Alvarez-Palomo, B;Osete, JR;Edel, MJ; Proteomic Analysis of Human iPSC-Derived Neural Stem Cells and Motor Neurons Identifies Proteasome Structural Alterations Cells 2023-12-08 [PMID: 38132120] (ICC, Human)
• Bilgic, M;Wu, Q;Suetsugu, T;Shitamukai, A;Tsunekawa, Y;Shimogori, T;Kadota, M;Nishimura, O;Kuraku, S;Kiyonari, H;Matsuzaki, F; Truncated radial glia as a common precursor in the late corticogenesis of gyrencephalic mammals eLife 2023-11-21 [PMID: 37988289] (IHC, Ferret)
• Garza, R;Sharma, Y;Atacho, DAM;Thiruvalluvan, A;Abu Hamdeh, S;Jönsson, ME;Horvath, V;Adami, A;Ingelsson, M;Jern, P;Hammell, MG;Englund, E;Kirkeby, A;Jakobsson, J;Marklund, N; Single-cell transcriptomics of human traumatic brain injury reveals activation of endogenous retroviruses in oligodendroglia Cell reports 2023-11-28 [PMID: 37967557] (Bioassay, Human)
• Muttathukunnel, P;Wälti, M;Aboouf, MA;Köster-Hegmann, C;Haenggi, T;Gassmann, M;Pannzanelli, P;Fritschy, JM;Schneider Gasser, EM; Erythropoietin regulates developmental myelination in the brain stimulating postnatal oligodendrocyte maturation Scientific reports 2023-11-09 [PMID: 37945644] (IHC, Mouse)
• Davaanyam, D;Lee, H;Seol, SI;Oh, SA;Kim, SW;Lee, JK; HMGB1 induces hepcidin upregulation in astrocytes and causes an acute iron surge and subsequent ferroptosis in the postischemic brain Experimental & molecular medicine 2023-11-01 [PMID: 37907744] (IHC, Rat)
• Seo, JS;Lee, SH;Won, HS;Yang, M;Nahm, SS;Nam, SM; Effects of Gestational and Lactational Lead Exposure and High Fat Diet Feeding on Cerebellar Development of Postnatal Rat Offspring Nutrients 2023-10-10 [PMID: 37892401] (IHC, Rat)
• Abdel Fattah, AR;Kolaitis, N;Van Daele, K;Daza, B;Rustandi, AG;Ranga, A; Targeted mechanical stimulation via magnetic nanoparticles guides in vitro tissue development Nature communications 2023-08-30 [PMID: 37644160] (IHC, Mouse)
• Walter, J;Mende, J;Hutagalung, S;Alhalabi, OT;Grutza, M;Zheng, G;Skutella, T;Unterberg, A;Zweckberger, K;Younsi, A; The Single-Dose Application of Interleukin-4 Ameliorates Secondary Brain Damage in the Early Phase after Moderate Experimental Traumatic Brain Injury in Mice International journal of molecular sciences 2023-08-14 [PMID: 37628939] (IHC, Mouse)
• Judith Niesen, Irm Hermans-Borgmeyer, Christina Krüger, Melanie Schoof, Franziska Modemann, Ulrich Schüller hGFAP-mediated GLI2 overexpression leads to early death and severe cerebellar malformations with rare tumor formation iScience 2023-09-15 [PMID: 37608807]
• Nilsson G, Mottahedin A, Zelco A et al. Two different isoforms of osteopontin modulate myelination and axonal integrity FASEB BioAdvances 2023-06-17 [PMID: 37554545]
• Baeza-Kallee, N;Bergès, R;Hein, V;Cabaret, S;Garcia, J;Gros, A;Tabouret, E;Tchoghandjian, A;Colin, C;Figarella-Branger, D; Deciphering the Action of Neuraminidase in Glioblastoma Models International journal of molecular sciences 2023-07-19 [PMID: 37511403] (ICC, Mouse)
• Mätlik, K;Baffuto, M;Kus, L;Deshmukh, AL;Davis, DA;Paul, MR;Carroll, TS;Caron, MC;Masson, JY;Pearson, CE;Heintz, N; Cell Type Specific CAG Repeat Expansions and Toxicity of Mutant Huntingtin in Human Striatum and Cerebellum bioRxiv : the preprint server for biology 2023-06-08 [PMID: 37333326] (Flow Cytometry, Western Blot, Human)
• Ryann M. Fame, Huixin Xu, Aja Pragana, Maria Lehtinen Age-appropriate potassium clearance from perinatal cerebrospinal fluid depends on choroid plexus NKCC1 Fluids and Barriers of the CNS 2023-06-16 [PMID: 37328833] (Immunohistochemistry, Mouse)
• Maruyama, T;Tanabe, S;Uyeda, A;Suzuki, T;Muramatsu, R; Free fatty acids support oligodendrocyte survival in a mouse model of amyotrophic lateral sclerosis Frontiers in cellular neuroscience 2023-05-12 [PMID: 37252191] (IHC, Mouse)
• Seeker, LA;Bestard-Cuche, N;J�kel, S;Kazakou, NL;B�strand, SMK;Wagstaff, LJ;Cholewa-Waclaw, J;Kilpatrick, AM;Van Bruggen, D;Kabbe, M;Baldivia Pohl, F;Moslehi, Z;Henderson, NC;Vallejos, CA;La Manno, G;Castelo-Branco, G;Williams, A; Brain matters: unveiling the distinct contributions of region, age, and sex to glia diversity and�CNS function Acta neuropathologica communications 2023-05-22 [PMID: 37217978] (IHC, Human)
• Pressl, C;M�tlik, K;Kus, L;Darnell, P;Luo, JD;Weiss, AR;Liguore, W;Carroll, TS;Davis, DA;McBride, J;Heintz, N; Layer 5a Corticostriatal Projection Neurons are Selectively Vulnerable in Huntington's Disease bioRxiv : the preprint server for biology 2023-04-24 [PMID: 37162977] (ICC, Human)
• Zhang, T;Pang, W;Feng, T;Guo, J;Wu, K;Nunez Santos, M;Arthanarisami, A;Nana, AL;Nguyen, Q;Kim, PJ;Jankowsky, JL;Seeley, WW;Hu, F; TMEM106B regulates microglial proliferation and survival in response to demyelination Science advances 2023-05-05 [PMID: 37146150] (IHC, Mouse)
• Zhang T, Feng T, Wu K et al. Progranulin deficiency results in sex-dependent alterations in microglia in response to demyelination Acta Neuropathologica 2023-07-01 [PMID: 37120788]
• Y Wang, D Sadike, B Huang, P Li, Q Wu, N Jiang, Y Fang, G Song, L Xu, W Wang, M Xie Regulatory T cells alleviate myelin loss and cognitive dysfunction by regulating neuroinflammation and microglial pyroptosis via TLR4/MyD88/NF-kappaB pathway in LPC-induced demyelination Journal of Neuroinflammation, 2023-02-18;20(1):41. 2023-02-18 [PMID: 36803990] (IHC, Mouse)
• B Rocamonde, S Alais, R Pelissier, V Moulin, B Rimbaud, R Lacoste, N Aurine, C Baquerre, B Pain, Y Tanaka, C Mathieu, H Dutartre STLV-1 Commonly Targets Neurons in the Brain of Asymptomatic Non-Human Primates MBio, 2023-02-21;0(0):e0352622. 2/21/2023 [PMID: 36802226]
• Wang J, Xu L, Peng D et al. IFN-?-STAT1-mediated CD8+ T-cell-neural stem cell cross talk controls astrogliogenesis after spinal cord injury Inflammation and regeneration 2023-02-13 [PMID: 36782279]
• H Park, B Cho, H Kim, T Saito, TC Saido, KJ Won, J Kim Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice Nature Communications, 2023-02-13;14(1):802. 2023-02-13 [PMID: 36781874] (Flow Cytometry, Mouse)
• M Ferren, A Lalande, M Iampietro, L Canus, D Decimo, D Gerlier, M Porotto, C Mathieu Early Permissiveness of Central Nervous System Cells to Measles Virus Infection Is Determined by Hyperfusogenicity and Interferon Pressure Viruses, 2023-01-13;15(1):. 2023-01-13 [PMID: 36680268] (Bioassay, Hamster - Mesocricetus auratus (Golden Hamster))
• Marie Gavid, Louise Coulomb, Justin Thomas, Inès Aouimeur, Paul Verhoeven, Marielle Mentek et al. Technique of flat-mount immunostaining for mapping the olfactory epithelium and counting the olfactory sensory neurons PLOS ONE 2023-01-17 [PMID: 36649285]
• Qing Zhao, Yanjing Zhu, Yilong Ren, Shuai Yin, Liqun Yu, Ruiqi Huang et al. Neurogenesis potential of oligodendrocyte precursor cells from oligospheres and injured spinal cord Frontiers in Cellular Neuroscience 2022-12-22 [PMID: 36619671]
• Samu N Kurki, Pavel Uvarov, Alexey S Pospelov, Kalevi Trontti, Antje K Hübner, Rakenduvadhana Srinivasan et al. Expression patterns of NKCC1 in neurons and non-neuronal cells during cortico-hippocampal development Cerebral Cortex 2023-05-09 [PMID: 36573432]
• S Chen, Y Chang, L Li, D Acosta, Y Li, Q Guo, C Wang, E Turkes, C Morrison, D Julian, ME Hester, DW Scharre, C Santiskulv, SX Song, JT Plummer, GE Serrano, TG Beach, KE Duff, Q Ma, H Fu Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer's disease Acta neuropathologica communications, 2022-12-21;10(1):188. 2022-12-21 [PMID: 36544231] (IHC, Human)
• SI Ramos, ZM Mussa, EN Falk, B Pai, B Giotti, K Allette, P Cai, F Dekio, R Sebra, KG Beaumont, AM Tsankov, NM Tsankova An atlas of late prenatal human neurodevelopment resolved by single-nucleus transcriptomics Nature Communications, 2022-12-12;13(1):7671. 2022-12-12 [PMID: 36509746] (Immunohistochemistry, Human)
• I Berglar, S Hehlgans, A Wehle, C Roth, C Herold-Men, F Rödel, D Kögel, B Linder CHRDL1 Regulates Stemness in Glioma Stem-like Cells Cells, 2022-12-03;11(23):. 2022-12-03 [PMID: 36497175] (Western Blot, Human)
• Arpan G. Mazumder, Amélie M. Julé, Paul F. Cullen, Daniel Sun Astrocyte heterogeneity within white matter tracts and a unique subpopulation of optic nerve head astrocytes iScience 2022-12-22 [PMID: 36465110]
• T Dierckx, S Vanherle, M Haidar, E Grajchen, F Mingneau, P Gervois, E Wolfs, D Bylemans, A Voet, T Nguyen, I Hamad, M Kleinewiet, JFJ Bogie, JJA Hendriks Phloretin enhances remyelination by stimulating oligodendrocyte precursor cell differentiation Proceedings of the National Academy of Sciences of the United States of America, 2022-11-07;119(46):e2120393119. 2022-11-07 [PMID: 36343243] (IHC, Mouse)
• Y Su, Y Zhou, ML Bennett, S Li, M Carceles-C, L Lu, S Huh, D Jimenez-Cy, BC Kennedy, SK Kessler, AN Viaene, I Helbig, X Gu, JE Kleinman, TM Hyde, DR Weinberger, DW Nauen, H Song, GL Ming A single-cell transcriptome atlas of glial diversity in the human hippocampus across the postnatal lifespan Cell Stem Cell, 2022-11-03;29(11):1594-1610.e8. 2022-11-03 [PMID: 36332572] (IHC, Human)
• T Zhou, Y Li, X Li, F Zeng, Y Rao, Y He, Y Wang, M Liu, D Li, Z Xu, X Zhou, S Du, F Niu, J Peng, X Mei, SJ Ji, Y Shu, W Lu, F Guo, T Wu, TF Yuan, Y Mao, B Peng Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice Nature Communications, 2022-10-24;13(1):6233. 2022-10-24 [PMID: 36280666] (IHC, Human)
• B Pai, J Tome-Garci, WS Cheng, G Nudelman, KG Beaumont, S Ghatan, F Panov, E Caballero, K Sarpong, L Marcuse, J Yoo, Y Jiang, A Schaefer, S Akbarian, R Sebra, D Pinto, E Zaslavsky, NM Tsankova High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy Acta neuropathologica communications, 2022-10-23;10(1):149. 2022-10-23 [PMID: 36274170] (IHC, Human)
• N Vilallongu, J Schaeffer, AM Hesse, C Delpech, B Blot, A Paccard, E Plissonnie, B Excoffier, Y Couté, S Belin, H Nawabi Guidance landscapes unveiled by quantitative proteomics to control reinnervation in adult visual system Nature Communications, 2022-10-13;13(1):6040. 2022-10-13 [PMID: 36229455] (IHC, Mouse)
• Hyun-Woo Jeong, Rodrigo Diéguez-Hurtado, Hendrik Arf, Jian Song, Hongryeol Park, Kai Kruse et al. Single-cell transcriptomics reveals functionally specialized vascular endothelium in brain eLife 2022-10-05 [PMID: 36197007]
• Bretheau F, Castellanos-Molina A, B�langer D et al. The alarmin interleukin-1? triggers secondary degeneration through reactive astrocytes and endothelium after spinal cord injury Nature Communications 2022-10-02 [PMID: 36184639]
• A Benraiss, JN Mariani, A Tate, PM Madsen, KM Clark, KA Welle, R Solly, L Capellano, K Bentley, D Chandler-M, SA Goldman A TCF7L2-responsive suppression of both homeostatic and compensatory remyelination in Huntington disease mice Cell Reports, 2022-08-30;40(9):111291. 2022-08-30 [PMID: 36044851] (IHC, Mouse)
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Reviews for Olig2 Antibody (AF2418) (2)

Average Rating: 4.5

(Based on 2 reviews)

We have 2 reviews tested in 1 species: Mouse.

reviewed by: Xuecheng Qiu IHC-Fr Mouse 05/12/2019

Summary

• Application: Immunohistochemistry-Frozen
• Sample Tested: Mouse brain
• Species: Mouse
• Lot: UPA0617051

reviewed by: Verified Customer ICC Mouse 01/06/2015

Summary

• Application: Immunocytochemistry
• Sample Tested: See PMID 22504067
• Species: Mouse

Bioinformatics

• Gene Symbol: OLIG2
• Uniprot:
  • Q13516()