Olig1 Antibody

Product Discontinued

Olig1 Antibody Summary

• Immunogen: Synthetic peptide, C-HPGGSARPDAKEEQ, representing this region of the sequence according to NP_620450.1
• Epitope: C-HPGGSARPDAKEEQ
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: OLIG1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA 1:128000
• Application Notes: Peptide ELISA: antibody detection limit dilution 1:2000. Western Blot: Preliminary experiments in Human Brain (Cerebellum, Hippocampus and Frontal Cortex) lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml). We would appreciate any feedback from people in the field - have any results been reported with other antibodies/lysates?

Reactivity Notes

Human.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: Tris (pH 7.3), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for Olig1 Antibody

• BHLHB6
• bHLHe21
• Class B basic helix-loop-helix protein 6
• Class E basic helix-loop-helix protein 21
• helix-loop-helix protein, class B, 6
• Olig1
• oligo1
• oligodendrocyte lineage transcription factor 1
• oligodendrocyte transcription factor 1
• oligodendrocyte-specific bHLH transcription factor 1

Background

Olig genes have been identified as the earliest known markers of oligodendrocyte lineage determination to date (Zhou et al., 2000). Olig1 is a transcription factor which promotes formation and maturation of oligodendrocytes, especially within the brain. It is expressed in the ventral spinal cord as early as 9.5 dpc and by 15.5 dpc, olig1 is dispersed throughout the gray matter. In the postnatal brain, it is present preferentially in the white matter, such as corpus callosum and cerebellar medulla. Olig1 has been demonstrated as necessary in the repair of brain lesions in patients with multiple sclerosis (Arnett et al. 2004).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: OLIG1
• Entrez:
  • 116448(Human)
• Uniprot:
  • NP_620450.1(Human)