Nurr1/NGFI-B beta/NR4A2 Antibody (HL1852) - Azide and BSA Free

Immunocytochemistry/Immunofluorescence: Nurr1/NGFI-B beta/NR4A2 Antibody (HL1852) - Azide and BSA Free [NBP3-25582] - Nurr1 antibody [HL1852] detects Nurr1 protein at cytoplasm and nucleus by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: Nurr1 stained by Nurr1 antibody [HL1852] (NBP3-25582) diluted at 1:500. Blue: Fluoroshield with DAPI .

• Reactivity: Hu
• Applications: ICC/IF
• Clone: HL1852
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: Azide and BSA Free

Nurr1/NGFI-B beta/NR4A2 Antibody (HL1852) - Azide and BSA Free Summary

• Description: Novus Biologicals Rabbit Nurr1/NGFI-B beta/NR4A2 Antibody (HL1852) - Azide and BSA Free (NBP3-25582) is a recombinant monoclonal antibody validated for use in ICC/IF. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: Recombinant fragment of human Nurr1/NGFI-B beta/NR4A2
• Source: HEK293
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: NR4A2
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:100-1:1000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Protein A purified

Alternate Names for Nurr1/NGFI-B beta/NR4A2 Antibody (HL1852) - Azide and BSA Free

• human homolog of
• NGFI-B beta
• NOT
• NR4A2
• nuclear receptor subfamily 4, group A, member 2
• Nurr1
• orphan nuclear receptor NR4A2
• Orphan nuclear receptor NURR1
• T-cell nuclear receptor NOT
• TINUR
• transcriptionally inducible nuclear receptor related 1
• Transcriptionally-inducible nuclear receptor

Background

The Nurr1 gene encodes a member of the steroid-thyroid hormone- retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson's. Nurr1 is a stem cell marker and cooperates with PITX3 to promote terminal maturation of murine and human embryonic stem cell cultures to a midbrain dopamine neuron phenotype. In addition, Nurr1 is involved in the regulation of corticotropin-releasing hormone (CRH), which may be linked to and associated with rheumatoid arthritis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: NR4A2