NMDAR2B [p Tyr1252] Antibody

Images

 
Western Blot: NMDAR2B [p Tyr1252] Antibody [NB300-292] - Rat hippocampal lysate showing specific immunolabeling of the ~180k NR2B subunit phosphorylated at Tyr1252 (Control). Phosphospecificity is shown in the second ...read more
Immunohistochemistry: NMDAR2B [p Tyr1252] Antibody [NB300-292] - Immunostaining of 14 DIV rat cortical neurons showing NR2B phosphorylated at Tyr1252 in red and PSD95 in green. Photo courtesy of Gang Liu

Product Details

Summary
Reactivity Mu, Rt, Hu, Mu, Bv, Ca, Ch, Pm, ZeSpecies Glossary
Applications WB, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

NMDAR2B [p Tyr1252] Antibody Summary

Immunogen
Phosphopeptide corresponding to amino acid residues surrounding the phosphoTyr1252 of the NR2B subunit of the rat NMDA receptor.
Modification
p Tyr1252
Localization
Integral membrane protein.
Specificity
Specific for ~180k NMDAR NR2B subunit protein phosphorylated at Tyr1252. Immunolabeling of the NMDA NR2B subunit band is blocked by the phosphopeptide used as the antigen but not by the corresponding dephosphopeptide. Immunolabeling is also blocked by lambda-phosphatase treatment. The antibody may also show some slight reactivity with Tyr1246 of NR2A.
Predicted Species
Human (100%), Mouse (100%), Canine (100%), Chicken (100%), Bovine (100%), Zebrafish (100%), Primate (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GRIN2B
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:1000
  • Immunohistochemistry 1:400
Application Notes
This antibody has been tested in Western blot on rat brain hippocampal lysate, detecting a band 180 kDa.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol
Preservative
No Preservative
Purity
Immunogen affinity purified

Alternate Names for NMDAR2B [p Tyr1252] Antibody

  • glutamate [NMDA] receptor subunit epsilon-2
  • glutamate receptor subunit epsilon-2
  • glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • hNR3
  • MGC142180
  • NMDAR2BMGC142178
  • N-methyl D-aspartate receptor subtype 2B
  • N-methyl-D-aspartate receptor subunit 3
  • NR2B
  • NR3

Background

The NMDA receptor (NMDAR) plays an essential role in memory, neuronal development and it has been implicated in several disorders of the CNS including Alzheimer's, epilepsy and ischemic neuronal death. Phosphorylation of Tyr 1252 is thought to potentiate NMDAR dependent influx of calcium. (1-6)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol GRIN2B
Entrez
Uniprot