NLRP7 Antibody

Images

 
Western Blot: NLRP7 Antibody [NBP1-76290] - Analysis of NALP7 in K562 cell lysate with NALP7 antibody at 2 ug/mL in (A) the absence and (B) the presence of blocking peptide.
Immunohistochemistry-Paraffin: NLRP7 Antibody [NBP1-76290] - Human brain tissue with NALP7 antibody at 10 ug/mL.
Immunofluorescence: NLRP7 Antibody [NBP1-76290] - Human brain tissue with NALP7 antibody at 20 ug/mL.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, IHC, IHC-P, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

NLRP7 Antibody Summary

Immunogen
Antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human NALP7. The immunogen is located within amino acids 90 - 140 of NALP7. Amino Acid Squence: LGDAEEDSELAKPGEKEG
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NLRP7
Purity
Peptide affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1 ug/ml
  • ELISA 1:100-1:2000
  • Immunohistochemistry 10 ug/ml
  • Immunohistochemistry-Paraffin 10 ug/ml
  • Immunofluorescence 20 ug/ml
Control Peptide
NLRP7 Peptide (NBP1-76290PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Peptide affinity purified

Alternate Names for NLRP7 Antibody

  • CLR19.4
  • MGC126471
  • NACHT, leucine rich repeat and PYD containing 7
  • NACHT, LRR and PYD containing protein 7
  • NACHT, LRR and PYD domains-containing protein 7
  • NALP7MGC126470
  • NLR family, pyrin domain containing 7
  • NOD12HYDM
  • Nucleotide-binding oligomerization domain protein 12
  • nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 7
  • PAN7
  • PYPAF3FLJ94610
  • PYRIN-containing APAF1-like protein 3

Background

NOD proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins. NALP7, also known as PYPAF3, a member of the related PYRIN-containing APAF1-like proteins (PYPAFs/NALPs) is thought to play a crucial role in cell proliferation. NALP7 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It is expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. NALP7 inhibits caspase-1-dependent interleukin-1beta secretion and is a feedback regulator of interleukin-1beta secretion. Defects in the NALP7 gene are known to cause the formation of a hydatidiform mole (HYDM) and reduce the growth of carcinoma cell lines.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Array NBP1-76290

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Bioinformatics

Gene Symbol NLRP7
Uniprot