NLRP7 Products

Description

NOD proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins. NALP7, also known as PYPAF3, a member of the related PYRIN-containing APAF1-like proteins (PYPAFs/NALPs) is thought to play a crucial role in cell proliferation. NALP7 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It is expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. NALP7 inhibits caspase-1-dependent interleukin-1beta secretion and is a feedback regulator of interleukin-1beta secretion. Defects in the NALP7 gene are known to cause the formation of a hydatidiform mole (HYDM) and reduce the growth of carcinoma cell lines.

Bioinformatics

Uniprot	NP_631915 Human
Product By Gene ID	199713
Alternate Names	CLR19.4 MGC126471 NACHT, leucine rich repeat and PYD containing 7 NACHT, LRR and PYD containing protein 7 NACHT, LRR and PYD domains-containing protein 7 NALP7 NALP7MGC126470 NLR family, pyrin domain containing 7 NLRP7 NOD12 NOD12HYDM Nucleotide-binding oligomerization domain protein 12 nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 7 PAN7 PYPAF3 PYPAF3FLJ94610 PYRIN-containing APAF1-like protein 3

Research Areas for NLRP7

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cell Biology
Immunology
Innate Immunity

Related NLRP7 Blog Posts

Check out the latest blog posts on NLRP7.

Pyroptosis: Mechanisms mediating cell death and pro-inflammatory cytokine release By Victoria OsinskiPyroptosis is an inflammatory form of programmed cell death characterized by the release of pro-inflammatory cytokines IL-1 beta and IL-18.1,10 It is a process distinct from apoptosis and necrosis (T...    Read more.

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