NLRP5 Antibody

Images

 
Western Blot: NLRP5 Antibody [NBP1-76289] - Mouse brain tissue lysate with NLRP5 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
Immunocytochemistry/ Immunofluorescence: NLRP5 Antibody [NBP1-76289] - Immunofluorescence of NALP5 in human brain tissue with NALP5 antibody at 20 ug/mL.
Immunohistochemistry-Paraffin: NLRP5 Antibody [NBP1-76289] - Human brain tissue with NALP5 antibody at 10 ug/mL.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

NLRP5 Antibody Summary

Immunogen
Antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human NALP5. The immunogen is located within the last 50 amino acids of NALP5. Amino Acid Squence: WHSFDEDDRYWWKN
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NLRP5
Purity
Peptide affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1 ug/ml
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 20 ug/ml
  • Immunohistochemistry 10 ug/ml
  • Immunohistochemistry-Paraffin 10 ug/ml
Control Peptide
NLRP5 Peptide (NBP1-76289PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Peptide affinity purified

Alternate Names for NLRP5 Antibody

  • CLR19.8
  • MATERMater protein homolog
  • NACHT, leucine rich repeat and PYD containing 5
  • NACHT, LRR and PYD domains-containing protein 5
  • NALP5maternal antigen that embryos require
  • NLR family, pyrin domain containing 5
  • nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 5
  • PAN11
  • PYPAF8

Background

NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP5, also known as MATER, is a maternal gene required for early embryonic development in mice. Increased NALP5 expression was observed in two neuronal injury models, and transient expression of recombinant NALP5 in neurons induced caspase-3 activation and apoptosis, suggesting that NALP5 also plays a role in caspase activation and apoptosis in injured neurons, and may thus represent a novel target for therapeutic treatment in neurodegenerative disorders.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Bioinformatics

Gene Symbol NLRP5
Uniprot