NKX2.2 Antibody (883411) [Alexa Fluor® 532]

• Reactivity: Hu, Mu, Rt
• Applications: WB, ICC/IF
• Clone: 883411
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 532

NKX2.2 Antibody (883411) [Alexa Fluor® 532] Summary

• Immunogen: E. coli-derived recombinant human NKX2.2
  Met1-Lys128
  Accession # O95096
• Specificity: Detects human NKX2.2 in ELISA and Western Blot.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for NKX2.2 Antibody (883411) [Alexa Fluor® 532]

• Homeobox protein NK-2 homolog B
• NK-2 (Drosophila) homolog B
• NK2 homeobox 2
• NK2 transcription factor related, locus 2 (Drosophila)
• NK2 transcription factor related, locus 2
• NK2 transcription factor-like protein B
• NKX2.2
• NKX2.2homeobox protein Nkx-2.2
• NKX2B
• NKX2BNK-2 homolog B

Background

NKX2.2, also known as NKX2-2 or NKX2B, is an approximately 30 kDa, 273 amino acid homeobox nuclear transcription factor of the NKX2 protein family. It specifies differentiation of pancreatic islet cells such as alpha, beta, PP, and epsilon lineages.  It also functions in developmental neuronal patterning of the ventral spinal cord in response to graded Sonic Hedgehog gradients and contributes pathfinding of commissural neurons. Within the region used as an immunogen, human NKX2.2 shares 96% and 97% amino acid sequence identity with mouse and rat NKX2.2, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.