Neurturin Antibody (126422)

• Reactivity: Hu
• Applications: WB, B/N
• Clone: 126422
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated

Neurturin Antibody (126422) Summary

• Immunogen: E. coli-derived recombinant human Neurturin
  Ala96-Val197
  Accession # Q99748
• Specificity: Detects human Neurturin in direct ELISAs and Western blots. In direct ELISAs, approximately 80% cross-reactivity with recombinant mouse Neurturin is observed and no cross-reactivity with recombinant mouse (rm) Artemin, recombinant human (rh) Cripto-1, recombinant Drosophila DPP, rhGDNF, rhLefty A, rmLefty-1, rhMIS, rmNodal, rmPersephin, rhTGF-beta 1, rhLatent TGF-beta 1, rhTGF-beta 1.2, rhTGF-beta 2 or rhTGF-beta 3 is observed.
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: NRTN
• Purity Statement: Protein A or G purified from hybridoma culture supernatant
• Endotoxin Note: <0.10 EU per 1 μg of the antibody by the LAL method.

Applications/Dilutions

• Dilutions:
  • Blockade of Receptor-ligand Interaction
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Neurturin Antibody (126422)

• Neurturin
• NRTN
• NTN

Background

Neurturin is a member of the GDNF family of ligands and is distantly related to TGF-beta family ligands. It is a disulfide-linked homodimer that interacts with a receptor complex composed of a high affinity ligand binding component (GFR alpha 1 or GFR alpha 2) and a common signaling component, cRET. Neurturin promotes the survival of a variety of neurons and possibly other cell types.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Neurturin Antibody (MAB387)(1)

Publication using MAB387

• J Sandmark, G Dahl, L Öster, B Xu, P Johansson, T Akerud, A Aagaard, P Davidsson, JM Bigalke, M Sörhede-Wi, GJ Rainey, RG Roth Structure and biophysical characterisation of the human full-length Neurturin-GFRa2 complex - a role for heparan sulfate in signalling J. Biol. Chem., 2018-02-02;0(0):. 2018-02-02 [PMID: 29414779] (ELISA Development (Detection), Rat)

Bioinformatics

• Gene Symbol: NRTN
• Uniprot:
  • Q99748()