NCOA6 Antibody


Western Blot: NCOA6 Antibody [NB200-336] - Samples from HeLa and 293T cells.
Immunohistochemistry-Paraffin: NCOA6 Antibody [NB200-336] - Human stomach carcinoma. Antibody used at a dilution of 1:1000 (1ug/ml).
Western Blot: NCOA6 Antibody [NB200-336] - Detection of Human ASC1 on HeLa whole cell lysates using NB200-336. Immunoprecipitated ASC1 was detected using an antibody NB200-336 to a distinctly different epitope on ASC1.
Immunoprecipitation: NCOA6 Antibody [NB200-336] - Detection of Human ASC2 by Western Blot of Immunoprecipitates

Product Details

Reactivity HuSpecies Glossary
Applications WB, IHC, IHC-P, IP
1.0 mg/ml

Order Details

NCOA6 Antibody Summary

The immunogen recognized by this antibody maps to a region between residue 2000 and the C-terminus (residue 2063) of human Activating Signal Cointegrator-2 using the numbering given in Swiss-Prot entry Q14686 (GeneID 23054).
NB200-336 is specific for human ASC2 protein.
Predicted Species
Equine (100%), Canine (100%), Primate (100%), Guinea Pig (100%), Rhesus Macaque (100%)
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at 4C. Do not freeze.
Tris-citrate/phosphate buffer, pH 7 to 8
0.09% Sodium Azide
1.0 mg/ml
Immunogen affinity purified


  • Western Blot 1:5000-1:10000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Immunoprecipitation 1-5 ug/mg lysate
Application Notes
This antibody is useful for Western Blot and Immunoprecipitation. Optimal working dilutions should be determined experimentally by the investigator. Prepare working dilution immediately before use. *In some cases, the antibody may be diluted further than indicated.
Read Publications using NB200-336.

Reactivity Notes

Based on 100% sequence identity, this antibody is predicted to react with Panda, Gorilla, Chimpanzee, White-tufted-ear marmoset, Crab-eating macaque, African elephant, Thirteen-lined ground squirrel, Little brown bat and Northern whitecheeked gibbon.

Alternate Names for NCOA6 Antibody

  • Activating signal cointegrator 2
  • AIB3NRC RAP250
  • Amplified in breast cancer protein 3
  • ASC-2
  • Cancer-amplified transcriptional coactivator ASC-2
  • KIAA0181PPAR-interacting protein
  • NRCamplified in breast cancer-3 protein
  • nuclear receptor coactivator 6
  • Nuclear receptor coactivator RAP250
  • Nuclear receptor-activating protein, 250 kDa
  • peroxisome proliferator-activated receptor interacting protein
  • PRIPPeroxisome proliferator-activated receptor-interacting protein
  • RAP250Thyroid hormone receptor-binding protein
  • thyroid hormone receptor binding protein
  • TRBPASC2activating signal cointegrator-2


Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. Involved in placental, cardiac, hepatic and embryonic development. NCOA6 is over-expressed in several breast cancer cell lines.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for NCOA6 Antibody (NB200-336)(2)

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Product General Protocols

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Video Protocols

WB Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies


Isotype Controls

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Blogs on NCOA6.

ASC-2: An important co-activator of different nuclear receptors
ASC-2, also known as Nuclear Receptor Co-Activator 6, directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. It is involved in the co-activation of different nuclear receptors, such as for steroi...  Read full blog post.

Contact Information

Product PDFs


Gene Symbol NCOA6

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