NCOA6 Antibody

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Western Blot: NCOA6 Antibody [NB200-336] - Detection of Human ASC2 by Western Blot. Samples: Nuclear extract (50 ug) from HeLa and 293T cells. Antibody: Affinity purified rabbit anti-ASC2 antibody NB200-336 used for WB ...read more
Immunoprecipitation: NCOA6 Antibody [NB200-336] - Detection of Human ASC2 by Western Blot of Immunoprecipitates

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml
   

Biological Strategies

     

Order Details

NCOA6 Antibody Summary

Immunogen
The immunogen recognized by this antibody maps to a region between residue 2000 and the C-terminus (residue 2063) of human Activating Signal Cointegrator-2 using the numbering given in Swiss-Prot entry Q14686 (GeneID 23054).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NCOA6
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:2000-1:10000
  • Immunoprecipitation 2 - 10 ug/mg lysate
Application Notes
This antibody is useful for Western Blot and Immunoprecipitation. Optimal working dilutions should be determined experimentally by the investigator. Prepare working dilution immediately before use. *In some cases, the antibody may be diluted further than indicated.
Positive Control
HeLa Lysate (NB800-PC9)
Publications
Read Publications using NB200-336.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Tris-Citrate/Phosphate (pH 7.0 - 8.0)
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for NCOA6 Antibody

  • Activating signal cointegrator 2
  • AIB3NRC RAP250
  • Amplified in breast cancer protein 3
  • ASC-2
  • Cancer-amplified transcriptional coactivator ASC-2
  • KIAA0181PPAR-interacting protein
  • NRCamplified in breast cancer-3 protein
  • nuclear receptor coactivator 6
  • Nuclear receptor coactivator RAP250
  • Nuclear receptor-activating protein, 250 kDa
  • peroxisome proliferator-activated receptor interacting protein
  • PRIPPeroxisome proliferator-activated receptor-interacting protein
  • RAP250Thyroid hormone receptor-binding protein
  • thyroid hormone receptor binding protein
  • TRBPASC2activating signal cointegrator-2

Background

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. Involved in placental, cardiac, hepatic and embryonic development. NCOA6 is over-expressed in several breast cancer cell lines.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for NCOA6 Antibody (NB200-336)(2)

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Product General Protocols

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Video Protocols

WB Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Research Areas for NCOA6 Antibody (NB200-336)

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Blogs on NCOA6.

ASC-2: An important co-activator of different nuclear receptors
ASC-2, also known as Nuclear Receptor Co-Activator 6, directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. It is involved in the co-activation of different nuclear receptors, such as for steroi...  Read full blog post.

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Bioinformatics

Gene Symbol NCOA6
Entrez
Uniprot