Species: Hu, Rt
Applications: WB, IHC, IP
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, IP
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. Involved in placental, cardiac, hepatic and embryonic development. NCOA6 is over-expressed in several breast cancer cell lines.
Bioinformatics
| Uniprot |
Human
Human
|
| Product By Gene ID |
23054 |
| Alternate Names |
- Activating signal cointegrator 2
- AIB3NRC RAP250
- Amplified in breast cancer protein 3
- ASC-2
- Cancer-amplified transcriptional coactivator ASC-2
- KIAA0181PPAR-interacting protein
- NRCamplified in breast cancer-3 protein
- nuclear receptor coactivator 6
- Nuclear receptor coactivator RAP250
- Nuclear receptor-activating protein, 250 kDa
- peroxisome proliferator-activated receptor interacting protein
- PRIPPeroxisome proliferator-activated receptor-interacting protein
- RAP250Thyroid hormone receptor-binding protein
- thyroid hormone receptor binding protein
- TRBPASC2activating signal cointegrator-2
|
