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NBR1 Antibody [DyLight 488]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 488

Order Details

NBR1 Antibody [DyLight 488] Summary

Immunogen
A genomic peptide made to an internal region of the human NBR1 protein (within residues 50-250). [Swiss-Prot Q14596]
Localization
Cytoplasm. Cytoplasmic vesicle - autophagosome. Lysosome. Cytoplasm - myofibril - sarcomere - M line. Note: In cardiac muscles localizes to the sarcomeric M line. Is targeted to lysosomes for degradation.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NBR1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
This NBR1 antibody is useful for Western blot, ICC/IF and IHC-P. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.

Reactivity Notes

Human and mouse. Immunogen has 75% identity to the rat protein.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for NBR1 Antibody [DyLight 488]

  • Cell migration-inducing gene 19 protein
  • FLJ98272
  • KIAA0049CA125
  • M17S2FLJ55359,1A1-3B
  • Membrane component chromosome 17 surface marker 2,1A13B
  • membrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigenCA125)
  • migration-inducing protein 19
  • Neighbor of BRCA1 gene 1 protein
  • neighbor of BRCA1 gene 1
  • next to BRCA1 gene 1 protein
  • Protein 1A1-3B

Background

NBR1 is a cargo receptor that sequesters ubiquinated proteins in the same manner as p62/SQSTM1, which leads to selective autophagy, sequestering the proteins into autophagomes. Both NBR1 and p62 localize to the endoplasmic reticulum independently of LC3. When the ability of cells to induce autophagy is impaired, aggregation of ubiquinated proteins occurs, and causes certain diseases. Particularly in neurodegenerative diseases, the functionality of NBR1 is adversely affected, which is related to the formation of protein aggregations within the brain. Analysis of the location and abundance of NBR1 in tissues can be a good indicator of autophagic failure and disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for NBR1 Antibody (NBP1-71703G) (0)

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Secondary Antibodies

 

Isotype Controls

Additional NBR1 Products

Bioinformatics Tool for NBR1 Antibody (NBP1-71703G)

Discover related pathways, diseases and genes to NBR1 Antibody (NBP1-71703G). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for NBR1 Antibody (NBP1-71703G)

Discover more about diseases related to NBR1 Antibody (NBP1-71703G).
 

Pathways for NBR1 Antibody (NBP1-71703G)

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PTMs for NBR1 Antibody (NBP1-71703G)

Learn more about PTMs related to NBR1 Antibody (NBP1-71703G).

Blogs on NBR1.

Understanding Mitophagy Mechanisms: Canonical PINK1/Parkin, LC3-Dependent Piecemeal, and LC3-Independent Mitochondrial Derived Vesicles
By Christina Towers, PhD What is Mitophagy?The selective degradation of mitochondria via double membrane autophagosome vesicles is called mitophagy. Damaged mitochondria can generate harmful amounts of reactive ox...  Read full blog post.

Monitoring Autophagy in Neurons
By Christina Towers, PhD. Autophagy is a critical cellular process used by most cells in the body to recycle nutrients and prevent harmful buildup of damaged proteins. It is particularly important in the brain, where ...  Read full blog post.

Why LC3B Antibodies Make Ideal Autophagosomes Membrane Markers
The human form of microtubule-associated protein light chain 3 (LC3) is expressed as 3 splice variants LC3A, LC3B, and LC3C.1 LC3B is a subunit of the MAP1A and MAP1B microtubule-binding proteins and plays a central role in autophagosome membrane stru...  Read full blog post.

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Contact Information

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Bioinformatics

Gene Symbol NBR1