Biological Strategies: Western Blot: BAF180/PB1 Antibody [NB100-79833] - Detection of Human and Mouse PB1/BAF180 by Western Blot. Samples : Whole cell lysate from HeLa (5, 15 and 50 ug), and 293T (50ug), and ...read more
Immunohistochemistry-Paraffin: BAF180/PB1 Antibody [NB100-79833] - Mouse teratoma. Antibody: Affinity purified rabbit anti- PBRM1used at a dilution of 1:1,000 (1ug/ml). Detection: DAB
Western Blot: BAF180/PB1 Antibody [NB100-79833] - Detection of Human and Mouse PB1/BAF180 on HeLa whole cell lysate using NB100-79833. PB1/BAF180 was immunoprecipitated by rabbit anti-PB1/BAF180 antibody NB100-79832.
Immunohistochemistry-Paraffin: BAF180/PB1 Antibody [NB100-79833] - Human ovarian carcinoma. Antibody: Affinity purified rabbit anti- PBRM1 used at a dilution of 1:1,000 (1ug/ml). Detection: DAB
The SMARCs (SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin), and BAFs (BRG1-associated factors), have been identified as components of the mammalian SWI/SNF-like chromatin-remodeling protein complexes. These multi-protein complexes are proposed to function as ATP-driven motors that translocate along DNA and destabilize nucleosomal structures to facilitate transcription factor binding. PB1/BAF180 is a component of the SWI/SNF-B (PBAF) complex. It contains six bromodomains which are defined by a 110 amino-acid module that interacts with acetylated lysine and is found in many chromatin binding proteins and histone acetyltransferases. PB1/BAF180 has been proposed to function as a tumor suppressor protein. Recently, PB1/BAF180 has been found to play a role in mediating cell cycle arrest in response to DNA damage via the regulation of the tumor suppressor p21. Alternate names for PB1/BAF180 include protein polybromo-1, polybromo-1D, BRG1-associated factor 180, hPB1, and PBRM1.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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