NALP4 Antibody

Images

 
Western Blot: NALP4 Antibody [NBP2-31375] - WB detection of NALP4/ NLRP4 protein in (A) K562 cell lysate and (B) partial recombinant protein by using NALP4 antibody at a concentration of: 1 ug/ml for lysate and 0.05 ...read more
Immunocytochemistry/ Immunofluorescence: NALP4 Antibody [NBP2-31375] - NALP4 antibody was tested in MCF7 cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

NALP4 Antibody Summary

Immunogen
Partial recombinant human NALP4 protein (between residues 1-300) [UniProt Q96MN2]
Localization
Cytoplasm
Specificity
Besides detecting canonical isoform (~113.4 kDa), this antibody may detect isoform 3 (104 kDa) also.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NLRP4
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1-2 ug/ml
  • Immunocytochemistry/Immunofluorescence 0.1 ug/ml

Reactivity Notes

Human. Immunogen shows 51% similarity with Mouse's NALP4.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein A purified

Alternate Names for NALP4 Antibody

  • Cancer/testis antigen 58
  • CLR19.5
  • CT58PYRIN and NACHT-containing protein 2
  • FLJ32126
  • NACHT, leucine rich repeat and PYD containing 4
  • NACHT, LRR and PYD domains-containing protein 4
  • NALP4NACHT, LRR and PYD containing protein 4
  • NLR family, pyrin domain containing 4
  • nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 4
  • PAN2Ribonuclease inhibitor 2
  • PYPAF4PAAD and NACHT-containing protein 2
  • RNH2PYRIN-containing APAF1-like protein 4

Background

NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP4, also known as PYRIN-containing APAF1-like protein 4, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. In transfected 293 cells, NALP4 suppressed NF-kappaB induction by TNF-alpha and IL-1beta, suggesting NALP4 operates at a point of convergence in these two signaling pathways. NALP4 also suppressed NF-kappaB induction resulting from overexpression of several adapter proteins and protein kinases involved in these pathways, including TRAF2, TRAF6, RIP, and IRAK2, as well as the IKK-alpha and IKK-beta, suggesting that NALP4 is critical in modulating NF-kappaB activity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Blogs on NALP4.

NALP4 - Mediator of Programmed Cell Death
The NALP family consists of cytoplasmic proteins within the larger CATERPILLER protein family. There exist in short forms (such as NALP4) and long forms (NALP1). NALP proteins include the apoptosis regulator apoptotic protease activating factor 1 (APA...  Read full blog post.

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Bioinformatics

Gene Symbol NLRP4
Entrez
Uniprot