WB, IHC, IHC-P, IPHost:
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003).
|Product By Gene ID
- NACHT, leucine rich repeat and PYD containing 4
- nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 4
- NACHT, LRR and PYD domains-containing protein 4
- NALP4NACHT, LRR and PYD containing protein 4
- RNH2PYRIN-containing APAF1-like protein 4
- CT58PYRIN and NACHT-containing protein 2
- PYPAF4PAAD and NACHT-containing protein 2
- PAN2Ribonuclease inhibitor 2
- Cancer/testis antigen 58
- NLR family, pyrin domain containing 4
Bioinformatics Tool for NALP4
Discover related pathways, diseases and genes to NALP4. Need help? Read the Bioinformatics Tool Guide
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Related NALP4 Blog Posts
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|NALP4 - Mediator of Programmed Cell Death
The NALP family consists of cytoplasmic proteins within the larger CATERPILLER protein family. There exist in short forms (such as NALP4) and long forms (NALP1). NALP proteins include the apoptosis regulator apoptotic protease activating factor 1 (APA... Read more.