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Myelin PLP Antibody

Images

 
Western Blot: Myelin PLP Antibody [NB100-74503] - Proteins were extracted from control (Ctrl) and stretched (Stretch) 158N cells and western blot was performed for myelin protein PLP (26 kDa) following 20% of strain. ...read more
Western Blot: Myelin PLP Antibody [NB100-74503] - Figure 1 shows a Western blot of PLP in adult mouse brain samples using NB100-74503. Figure 2 shows an immunocytochemical staining of PLP in mouse brain thick section ...read more
Western Blot: Myelin PLP Antibody [NB100-74503] - Analysis of adult mouse brain samples.

Product Details

Summary
Reactivity Mu, RtSpecies Glossary
Applications WB, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

Myelin PLP Antibody Summary

Immunogen
Synthetic peptide corresponding to residues C(109) G K G L S A T V T G G Q K G R G S R G(128) of PLP.
Localization
Membrane; Multi pass membrane protein.
Marker
Oligodendrocyte Marker
Specificity
PLP
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PLP1
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence
  • Western Blot 1:1000
Application Notes
Useful in IHC and WB. WB: Detects an approx. 26 - 29 kDa protein representing the proteolipid protein in adult mouse brain samples. Use in Immunocytochemistry/immunofluorescence reported in scientific literature (PMID: 20594620).
Publications
Read Publications using
NB100-74503 in the following applications:

Reactivity Notes

Rat reactivity reported in scientific literature (PMID: 20594620).

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
Whole antisera
Preservative
0.05% Sodium Azide
Purity
Unpurified

Alternate Names for Myelin PLP Antibody

  • DM-20
  • HLD1
  • Lipophilin
  • major myelin proteolipid protein
  • MMPL
  • Myelin PLP
  • myelin proteolipid protein
  • PLP
  • PLP/DM20
  • PLP1
  • PMD
  • proteolipid protein 1
  • spastic paraplegia 2, uncomplicated
  • SPG2

Background

Myelin proteins associated with the central nervous system (CNS) are thought to be unique to the CNS, and play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. The proteolipid protein (PLP) and the splice variant DM20 are the predominant myelin proteins in the CNS. PLP is also one of the most extensively studied myelin proteins because of the prevelance of PLP mutations amongst humans and animals. Such mutations can lead to abnormal myelin formation resulting in conditions such as X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Myelin PLP Antibody (NB100-74503)(5)

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 2 applications: ICC/IF, WB.


Filter By Application
ICC/IF
(1)
WB
(4)
All Applications
Filter By Species
Mouse
(3)
Rat
(1)
All Species

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Myelin PLP Antibody (NB100-74503) (0)

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for Myelin PLP Antibody (NB100-74503)

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Bioinformatics

Gene Symbol PLP1
Entrez