Myelin PLP Antibody (CL10622) - BSA Free

Immunohistochemistry-Paraffin: Myelin PLP Antibody (CL10622) [NBP3-07989] - Analysis in human cerebral cortex and tonsil tissues using NBP3-07989 antibody. Corresponding Myelin PLP RNA-seq data are presented for the same tissues.

Immunohistochemistry-Paraffin: Myelin PLP Antibody (CL10622) [NBP3-07989] - Staining of human tonsil shows no positivity in lymphoid cells as expected.

Immunohistochemistry-Paraffin: Myelin PLP Antibody (CL10622) [NBP3-07989] - Staining of human cerebellum shows strong positivity in myelinated neuronal processes.

Immunohistochemistry-Paraffin: Myelin PLP Antibody (CL10622) [NBP3-07989] - Staining of human cerebral cortex shows strong positivity in myelinated neural fibers.

Immunohistochemistry-Paraffin: Myelin PLP Antibody (CL10622) [NBP3-07989] - Staining of human kidney shows no positivity as expected.

Immunohistochemistry-Paraffin: Myelin PLP Antibody (CL10622) [NBP3-07989] - Staining of rat cerebral cortex shows strong positivity in myelinated neuronal processes and in oligodendrocytes cell bodies.

• Reactivity: Hu, Rt, Mu
• Applications: IHC
• Clone: CL10622
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: BSA Free

Myelin PLP Antibody (CL10622) - BSA Free Summary

• Description: Novus Biologicals Mouse Myelin PLP Antibody (CL10622) - BSA Free (NBP3-07989) is a monoclonal antibody validated for use in IHC. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: This antibody was developed using a recombinant protein derived from P60201, with the exact immunogen sequence remaining proprietary.
• Predicted Species: Mouse (100%). Backed by our 100% Guarantee.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: PLP1
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:500 - 1:1000
  • Immunohistochemistry-Paraffin 1:500 - 1:1000
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Protein A purified

Alternate Names for Myelin PLP Antibody (CL10622) - BSA Free

• DM-20
• HLD1
• Lipophilin
• major myelin proteolipid protein
• MMPL
• Myelin PLP
• myelin proteolipid protein
• PLP
• PLP/DM20
• PLP1
• PMD
• proteolipid protein 1
• spastic paraplegia 2, uncomplicated
• SPG2

Background

Human PLP (also known as lipophilin) is a 30 kDa protein (277 amino acids) found in myelin of the CNS and PNS. Expressed by oligodendrocytes and Schwann cells, PLP stabilizes myelin by preventing lipid bilayer fusion, and aids in compaction. Different mutations of the human PLP gene product result in two neurological disorders - Pelizaeus-Merzbacher disease and Spastic Paraplegia type 2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PLP1