Musculin Antibody

Product Discontinued

Musculin Antibody Summary

• Immunogen: Peptide with sequence C-PLKSDWNSLDGIIR corresponding to C-Terminus according to AAC15071.1.
• Epitope: PLKSDWNSLDGIIR
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: MSC
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:32000
  • Western Blot 1 - 3 ug/ml
• Application Notes: WB: Approx. 25 kDa band observed in human bone marrow lysates (calculated MW of 23.6 kDa band according to AAC15071.1).

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Musculin Antibody

• ABF1
• ABF-1activated B-cell factor 1, homolog of mouse musculin
• Activated B-cell factor 1
• BHLHA22
• bHLHa22activated B-cell factor-1
• Class A basic helix-loop-helix protein 22
• musculin (activated B-cell factor-1)
• musculin
• MYOR

Background

The predicted 218-amino acid protein contains a bHLH motif, a putative nuclear localization signal, a glycine-rich region, and a stretch of acidic residues. MSC is capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro, and forms heterodimers with E2A proteins in vivo. MSC contains a transcriptional repression domain and is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. MSC is a downstream target of the B-cell receptor signal transduction pathway.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Musculin Antibody (NB100-789)(1)

Publication using NB100-789

• Massari ME, Rivera RR, Voland JR et al. Characterization of ABF-1, a novel basic helix-loop-helix transcription factorexpressed in activated B lymphocytes. Mol Cell Biol 1998 Jun [PMID: 9584154]

Bioinformatics

• Gene Symbol: MSC
• Entrez:
  • 9242(Human)
• Uniprot:
  • NP_005089.(Human)