Western Blot: MTA2 Antibody [NB100-56483] - analysis using MTA2 antibody. Lysate from Jurkat cells, in the 1) absence and 2) presence of immunizing peptide, probed with MTA2 antibody at 0.5 ug/ml. I goat anti-rabbit Ig ...read more
Immunocytochemistry/ Immunofluorescence: MTA2 Antibody [NB100-56483] - MTA2 antibody was tested in HEK293 cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 ...read more
Immunohistochemistry: MTA2 Antibody [NB100-56483] - IHC analysis of Human Testis using NB100-56483 at 10 ug/ml.
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
75 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Reacts with Chimpanzee, Human and Rhesus Monkey. Predicted cross-reactivity based on sequence identity: Mouse (94%), Rat (94%), Dog (88%), Bovine (88%) and Xenopus (76%).
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS containing 0.05% BSA
0.05% Sodium Azide
Immunogen affinity purified
Alternate Names for MTA2 Antibody
metastasis associated 1 family, member 2
metastasis -associated gene 1-like 1
metastasis associated gene family, member 2
Metastasis-associated 1-like 1
metastasis-associated protein 2
metastasis-associated protein MTA2
p53 target protein in deacetylase complex
Gene Map Locus: 11q12-q13.1 (human) MTA2, a homologue of human MTA1 and MTA3, is a member of highly conserved MTA gene family. It is a component of NuRD, an ATP-dependent nucleosome remodeling and histone deacetylase complex. MTA2 is a nuclear protein that interacts with HDAC1 and HDAC2 and has a functional role in chromatin remodeling and deacetylase activity. MTA2 specifically interacts with p53 and represses p53-dependant transcriptional activation, thereby regulating p53-mediated cell growth arrest and apoptosis. It also inhibits the transcriptional activity of Estrogen receptor-alpha. Northern Blot analysis detected a ubiquitous expression of MTA2.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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