MTA2 Antibody

Images

 
Western Blot: MTA2 Antibody [NB100-56483] - analysis using MTA2 antibody. Lysate from Jurkat cells, in the 1) absence and 2) presence of immunizing peptide, probed with MTA2 antibody at 0.5 ug/ml. I goat anti-rabbit Ig ...read more
Immunocytochemistry/ Immunofluorescence: MTA2 Antibody [NB100-56483] - MTA2 antibody was tested in HEK293 cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 ...read more
Immunohistochemistry: MTA2 Antibody [NB100-56483] - IHC analysis of Human Testis using NB100-56483 at 10 ug/ml.

Product Details

Summary
Reactivity Hu, Pm, Mu, RtSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

MTA2 Antibody Summary

Immunogen
A portion of amino acids 650-700 of human MTA2 was used as the immunogen (NP_004730).
Predicted Species
Mouse (94%), Rat (94%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
MTA2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.5-2 ug/ml
  • Immunocytochemistry/Immunofluorescence 1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 5-10 ug/ml
Application Notes
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
75 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publication using NB100-56483.

Reactivity Notes

Reacts with Chimpanzee, Human and Rhesus Monkey. Predicted cross-reactivity based on sequence identity: Mouse (94%), Rat (94%), Dog (88%), Bovine (88%) and Xenopus (76%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS containing 0.05% BSA
Preservative
0.05% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for MTA2 Antibody

  • DKFZp686F2281
  • metastasis associated 1 family, member 2
  • metastasis -associated gene 1-like 1
  • metastasis associated gene family, member 2
  • Metastasis-associated 1-like 1
  • metastasis-associated protein 2
  • metastasis-associated protein MTA2
  • MTA1-L1 protein
  • MTA1L1MTA1-L1
  • p53 target protein in deacetylase complex
  • PID

Background

Gene Map Locus: 11q12-q13.1 (human) MTA2, a homologue of human MTA1 and MTA3, is a member of highly conserved MTA gene family. It is a component of NuRD, an ATP-dependent nucleosome remodeling and histone deacetylase complex. MTA2 is a nuclear protein that interacts with HDAC1 and HDAC2 and has a functional role in chromatin remodeling and deacetylase activity. MTA2 specifically interacts with p53 and represses p53-dependant transcriptional activation, thereby regulating p53-mediated cell growth arrest and apoptosis. It also inhibits the transcriptional activity of Estrogen receptor-alpha. Northern Blot analysis detected a ubiquitous expression of MTA2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for MTA2 Antibody (NB100-56483)(1)

We have publications tested in 1 application: WB.


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Product General Protocols

View specific protocols for MTA2 Antibody (NB100-56483): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol MTA2
Entrez
Uniprot