MTA2 Products

Description

Official Gene Symbol: MTA2 Gen Bank Accession Number: NP_004730 Gene ID: 9219 (Human) Gene Map Locus: 11q12-q13.1 (human) MTA2, a homologue of human MTA1 and MTA3, is a member of highly conserved MTA gene family. It is a component of NuRD, an ATP-dependent nucleosome remodeling and histone deacetylase complex. MTA2 is a nuclear protein that interacts with HDAC1 and HDAC2 and has a functional role in chromatin remodeling and deacetylase activity. MTA2 specifically interacts with p53 and represses p53-dependant transcriptional activation, thereby regulating p53-mediated cell growth arrest and apoptosis. It also inhibits the transcriptional activity of Estrogen receptor-alpha. Northern Blot analysis detected a ubiquitous expression of MTA2.

Bioinformatics

Entrez	23942 Mouse 361724 Rat 9219 Human
Uniprot	AAG02241 Human NP_004730 Human NP_004730.2 Human O94776 Human
Product By Gene ID	9219
Alternate Names	DKFZp686F2281 metastasis associated 1 family, member 2 metastasis -associated gene 1-like 1 metastasis associated gene family, member 2 Metastasis-associated 1-like 1 metastasis-associated protein 2 metastasis-associated protein MTA2 MTA1-L1 protein MTA1L1MTA1-L1 p53 target protein in deacetylase complex PID

Research Areas for MTA2

Find related products by research area and learn more about each of the different research areas below.

Cancer
Chromatin Research
Phospho-Specific
Transcription Factors and Regulators
Tumor Suppressors