MSX2 Antibody (786607) [Alexa Fluor® 488]

• Reactivity: Hu
• Applications: ICC/IF
• Clone: 786607
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 488

MSX2 Antibody (786607) [Alexa Fluor® 488] Summary

• Immunogen: E. coli-derived recombinant human MSX2
  Ala2-Thr132
  Accession # P35548
• Specificity: Detects human MSX2 in ELISAs. In direct ELISAs, no cross-reactivity with recombinant human MSX1 is observed.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for MSX2 Antibody (786607) [Alexa Fluor® 488]

• CRS2
• CRS2parietal foramina 1
• FPP
• Homeobox protein Hox-8
• homeobox protein MSX-2
• Hox8
• HOX8msh homeobox homolog 2 (Drosophila)
• msh (Drosophila) homeo box homolog 2
• msh homeo box 2
• msh homeobox 2
• msh homeobox homolog 2
• MSH
• MSX2
• PFM
• PFM1

Background

MSX2, also known as HOX-8, is an approximately 35 kDa homeobox transcription factor that is a downstream target of canonical Wnt signaling. MSX2 plays an important role in the development of mineralized tissues including bone, cartilage, and teeth. It is upregulated in atherosclerotic plaques and promotes the calcification of vascular smooth muscle cells during inflammation. MSX2 suppresses the adipocytic differentiation of multipotent mesenchymal cells. MSX2 acts in mammary gland development and the initiation of female fetal germ cell meiosis. It promotes tumorigenesis of breast and pancreatic carcinomas but inhibits the survival and invasiveness of melanoma cells. Human MSX2 contains one homeodomain (aa 143-201). Within aa 1-132, human MSX2 shares 87% aa sequence identity with mouse and rat MSX2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.