Mre11-Rad50-NBS1 Complex Antibody Pack

Images

 
Western Blot: Mre11-Rad50-NBS1 Complex Antibody Pack [NB100-914] - Detection of human NBS1.
Immunohistochemistry: Mre11-Rad50-NBS1 Complex Antibody Pack [NB100-914] - MRE11 staining in the human epidermis detected.
Western Blot: Mre11-Rad50-NBS1 Complex Antibody Pack [NB100-914] - Analysis of Mre11 on 50 ug of HeLa and MEF lysates.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, IHC
Host
Rabbit

Order Details

Mre11-Rad50-NBS1 Complex Antibody Pack Summary

Immunogen
See individual datasheets.
Specificity
See individual datasheets.
Host
Rabbit
Gene
MRE11A

Applications/Dilutions

Application Notes
See individual datasheets.
Publications
Read Publication using NB100-914.

Reactivity Notes

See individual datasheets.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.

Kit Components

Notes

1 vial each of: NB100-142 (0.1ml), NB100-143 (0.1ml) and NB100-154 (0.1ml).

Alternate Names for Mre11-Rad50-NBS1 Complex Antibody Pack

  • ATLDmeiotic recombination (S. cerevisiae) 11 homolog A
  • AT-like disease
  • DNA recombination and repair protein
  • double-strand break repair protein MRE11A
  • endo/exonuclease Mre11
  • HNGS1
  • Meiotic recombination 11 homolog 1
  • Meiotic recombination 11 homolog A
  • MRE11 homolog 1
  • MRE11 homolog A
  • MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
  • MRE11MRE11B

Background

We know how important it is to your research to have access to antibodies specific for your model. As it is often impossible to know which antibody will work best for a specific sample and application, we now offer SuperNovus Packs. These packs include different antibodies to the same protein to give you the ability to decide for yourself. The SuperNovus Packs are all offered at a discount price compared to purchasing each antibody individually. The hMre11-hRad50-NBS1 protein plays a central role in the human cellular DNA-Damage response, with recent studies indicating that these proteins help link DNA-damage detection to DNA-repair and cell cycle-checkpoint functions. This protein complex has been implicated in the activation of cell cycle-regulatory pathways, due to the fact that the NBS1 gene mutates in the chromosomal-instability syndrome, Nijmegen breakdown syndrome (NBS), which is characterized by increased cancer incidence, cell cycle checkpoint defects, and ionizing radiation sensitivity. HMre11-hRad50 foci form in response to DNA double-strand breaks and rely upon a DNA damage-induced signaling pathway. However, hMre11 migrates to sites of damage while hRad51 does not localize at these sites. These findings are consistent with the distinct role of these proteins in DNA repair.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Antibody Packs are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Mre11-Rad50-NBS1 Complex NB100-914

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Bioinformatics

Gene Symbol MRE11A