Mre11-Rad50-NBS1 Complex Antibody Pack

Images

 
Genetic Strategies: Knockout Validated: Mre11-Rad50-NBS1 Complex Antibody Pack [NB100-914] - Lysates of HeLa human cervical epithelial carcinoma parental cell line and Nbs1 knockout (KO) HeLa cell line. PVDF ...read more
Simple Western: Mre11-Rad50-NBS1 Complex Antibody Pack [NB100-914] - Image shows a specific band for Mre11 in 0.5 mg/mL of HeLa lysate using NB100-142. This experiment was performed under reducing conditions using the ...read more
Simple Western: Mre11-Rad50-NBS1 Complex Antibody Pack [NB100-914] - Simple Western lane view shows a specific band for Rad50 in 0.5 mg/ml of HeLa lysate using NB100-154. This experiment was performed under reducing ...read more
Immunocytochemistry/ Immunofluorescence: Mre11-Rad50-NBS1 Complex Antibody Pack [NB100-914] - ICC/IF analysis of Nbs1 in HeLa cells with Nbs1 Antibody [NB100-143]. Image from verified customer review.
Immunohistochemistry-Paraffin: Mre11-Rad50-NBS1 Complex Antibody Pack [NB100-914] - FFPE human testis using Nbs1 antibody [NB100-143] at 1:200 on a Bond Rx autostainer (Leica Biosystems). The assay involved 20 minutes ...read more
Immunocytochemistry/ Immunofluorescence: Mre11-Rad50-NBS1 Complex Antibody Pack [NB100-914] - Staining of Mre11 using NB100-142 on HeLa cells. Image from verified customer review.
Immunohistochemistry: Mre11-Rad50-NBS1 Complex Antibody Pack [NB100-914] - MRE11 staining using NB100-142 in the human epidermis detected.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, Simple Western, ICC/IF, IHC, IHC-P, KO
Host
Rabbit
Validated by:
     

Genetic Strategies

   

Order Details

Mre11-Rad50-NBS1 Complex Antibody Pack Summary

Immunogen
See individual datasheets.
Specificity
See individual datasheets.
Host
Rabbit
Gene
MRE11

Applications/Dilutions

Application Notes
See individual datasheets for validated applications.
Publications
Read Publication using NB100-914.

Reactivity Notes

See individual datasheets.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.

Kit Components

Notes

This pack contains 1 vial each of: NB100-142 (0.05 mL), NB100-143 (0.05 mL) and NB100-154 (0.1 mL).

Alternate Names for Mre11-Rad50-NBS1 Complex Antibody Pack

  • ATLDmeiotic recombination (S. cerevisiae) 11 homolog A
  • AT-like disease
  • DNA recombination and repair protein
  • double-strand break repair protein MRE11A
  • endo/exonuclease Mre11
  • HNGS1
  • Meiotic recombination 11 homolog 1
  • Meiotic recombination 11 homolog A
  • MRE11 homolog 1
  • MRE11 homolog A
  • MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
  • MRE11MRE11B

Background

We know how important it is to your research to have access to antibodies specific for your model. As it is often impossible to know which antibody will work best for a specific sample and application, we now offer SuperNovus Packs. These packs include different antibodies to the same protein to give you the ability to decide for yourself. The SuperNovus Packs are all offered at a discount price compared to purchasing each antibody individually. The hMre11-hRad50-NBS1 protein plays a central role in the human cellular DNA-Damage response, with recent studies indicating that these proteins help link DNA-damage detection to DNA-repair and cell cycle-checkpoint functions. This protein complex has been implicated in the activation of cell cycle-regulatory pathways, due to the fact that the NBS1 gene mutates in the chromosomal-instability syndrome, Nijmegen breakdown syndrome (NBS), which is characterized by increased cancer incidence, cell cycle checkpoint defects, and ionizing radiation sensitivity. HMre11-hRad50 foci form in response to DNA double-strand breaks and rely upon a DNA damage-induced signaling pathway. However, hMre11 migrates to sites of damage while hRad51 does not localize at these sites. These findings are consistent with the distinct role of these proteins in DNA repair.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Antibody Packs are guaranteed for 1 year from date of receipt.

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Publications for Mre11-Rad50-NBS1 Complex Antibody Pack (NB100-914)(1)

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Bioinformatics

Gene Symbol MRE11