Mouse TIM-1/KIM-1/HAVCR Quantikine ELISA Kit

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications ELISA
Conjugate
HRP

Order Details

Mouse TIM-1/KIM-1/HAVCR Quantikine ELISA Kit Summary

Background
The Quantikine Mouse TIM-1 Immunoassay is a 3.5 hour solid phase ELISA designed to measure mouse TIM-1 in cell culture supernates, serum, plasma, and urine. It contains NS0-expressed recombinant mouse TIM-1 and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant factor accurately. Results obtained using natural mouse TIM-1 showed do...se-response curves that were parallel to the standard curves obtained using the recombinant kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse TIM-1.
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Specificity
Natural and recombinant mouse TIM-1. The antibody components of this kit were raised against the short splice form of mouse TIM-1 (isoform 2) which has a 23 amino acid deletion following Pro182. This immunoassay detects both the short and long forms of mouse TIM-1.
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
Havcr1

Applications/Dilutions

Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using MKM100.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse TIM-1/KIM-1/HAVCR Quantikine ELISA Kit

  • CD365
  • HAVCR1
  • HAVCR-1
  • HAVCRT cell immunoglobin domain and mucin domain protein 1
  • hepatitis A virus cellular receptor 1
  • Kidney injury molecule 1
  • KIM1
  • KIM-1
  • T-cell immunoglobulin and mucin domain-containing protein 1
  • TIM1
  • TIM-1
  • TIM-1TIM
  • TIM1TIMD-1
  • TIMD1T-cell membrane protein 1

Background

TIM-1 (T cell immunoglobulin and mucin domain 1), also known as KIM-1 and HAVcr1, is expressed on many immune cell types and epithelial cells. It binds to phosphatidylserine (PS), LMIR5/CD300b, TIM-1 (homophilic), TIM-4, IgA, and the glycoproteins of a number of enveloped viruses. Its interaction with PS enables TIM-1 to mediate the phagocytosis and clearance of apoptotic cells. TIM-1 signaling costimulates T cell activation and enhances Th2 cytokine production. TIM-1 serves as a cellular entry receptor for hepatitis A virus, Ebolavirus and Marburgvirus. Polymorphisms are associated with susceptibility to atopy, autoimmunity, and severe hepatitis A virus infection in humans. A soluble form of TIM-1 is elevated in the urine during nephropathy.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for TIM-1/KIM-1/HAVCR (MKM100)(7)

We have publications tested in 1 confirmed species: Mouse.


Filter By Application
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Mouse
(7)
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Showing Publications 1 - 7 of 7.
Publications using MKM100 Applications Species
YS Luo, JA Cichocki, NH Hsieh, L Lewis, FA Wright, DW Threadgill, WA Chiu, I Rusyn Using Collaborative Cross Mouse Population to Fill Data Gaps in Risk Assessment: A Case Study of Population-Based Analysis of Toxicokinetics and Kidney Toxicodynamics of Tetrachloroethylene Environ. Health Perspect., 2019;127(6):67011. 2019 [PMID: 31246107] (Mouse) Mouse
WZ Ying, X Li, S Rangarajan, W Feng, LM Curtis, PW Sanders Immunoglobulin light chains generate proinflammatory and profibrotic kidney injury J. Clin. Invest., 2019;129(7):2792-2806. 2019 [PMID: 31205024] (Mouse) Mouse
C De Miguel, WC Hamrick, R Sedaka, S Jagarlamud, LD Asico, PA Jose, S Cuevas Uncoupling Protein 2 Increases Blood Pressure in DJ -1 Knockout Mice J Am Heart Assoc, 2019;8(9):e011856. 2019 [PMID: 30995881] (Mouse) Mouse
ZV Varga, K Erdelyi, J Paloczi, R Cinar, ZK Zsengeller, T Jourdan, C Matyas, NT Balazs, A Guillot, X Xiang, A Mehal, G Hasko, IE Stillman, S Rosen, B Gao, G Kunos, P Pacher Disruption of renal arginine metabolism promotes kidney injury in hepatorenal syndrome Hepatology, 2018;0(0):. 2018 [PMID: 29631342] (Mouse) Mouse
H Meng, G Fu, J Shen, K Shen, Z Xu, Y Wang, B Jin, H Pan Ameliorative Effect of Daidzein on Cisplatin-Induced Nephrotoxicity in Mice via Modulation of Inflammation, Oxidative Stress, and Cell Death Oxid Med Cell Longev, 2017;2017(0):3140680. 2017 [PMID: 28831294] (Mouse) Mouse
N Maicas, J van der Vl, J Bublitz, S Florquin, M Bakker-van, CA Dinarello, V Verweij, R Masereeuw, LA Joosten, LB Hilbrands Human Alpha-1-Antitrypsin (hAAT) therapy reduces renal dysfunction and acute tubular necrosis in a murine model of bilateral kidney ischemia-reperfusion injury PLoS ONE, 2017;12(2):e0168981. 2017 [PMID: 28235038] (Mouse) Mouse
Okada H, Senmaru T, Fukui M, Kondo Y, Ishigami A, Maruyama N, Obayashi H, Yamazaki M, Nakamura N, Hasegawa G Senescence marker protein-30/gluconolactonase deficiency exacerbates diabetic nephropathy through tubular injury in a mouse model of type 1 diabetes. J Diabetes Investig, 2015;6(1):35-43. 2015 [PMID: 25621131] (Mouse) Mouse

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Product General Protocols

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FAQs for TIM-1/KIM-1/HAVCR (MKM100). (Showing 1 - 1 of 1 FAQs).

  1. wondering what the difference is between your quantikine and duo set elisas?
    • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Other Available Formats

HRP MKM100

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Bioinformatics

Gene Symbol Havcr1