Mouse/Rat FGF-21 Quantikine ELISA Kit

• Reactivity: Mu, Rt
• Applications: ELISA
• Conjugate: HRP

Mouse/Rat FGF-21 Quantikine ELISA Kit Summary

• Background: The Quantikine Mouse/Rat FGF-21 immunoassay is a 4.5 hour solid-phase ELISA designed to measure FGF-21 in mouse or rat cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant mouse FGF-21 and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant mouse FGF-21. Results obtained using natural mous...e or rat FGF-21 showed dose response curves that were parallel to the standard curves obtained using the Quantikine mouse kit standards. These results indicate that this kit can be used to determine relative mass values for natural FGF-21.
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• Specificity: Natural and recombinant mouse and rat FGF-21
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Fgf21

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse/Rat FGF-21 Quantikine ELISA Kit

• FGF21
• FGF-21
• fibroblast growth factor 21

Background

FGF-21 (Fibroblast Growth Factor 21) is a member of an FGF subfamily that also includes FGF-19 and FGF-23. FGF-19 subfamily members lack a heparin binding domain, enabling them to freely circulate as endocrine factors and diffuse within tissues. FGF-21 signals through Klotho beta in complex with FGF receptors. It regulates cellular metabolism including glucose uptake in adipocytes and cellular sensitivity to insulin. It is basally expressed in the pancreas, thymus, liver, and adipose tissue and is upregulated in liver, muscle, and fat in obesity and diabetes. FGF-21 also plays a role in cell survival and proliferation, mesenchymal stem cell differentiation, circadian rhythm, and controlling reproductive capacity.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for FGF-21 (MF2100)(125)

Publications using MF2100

• Yuan, X;Sun, W;Xu, Y;Xiang, M;Gao, Y;Feng, W;Xiao, H;Zhang, L;Tang, Q;Lu, J;Zhang, Y; Altered mitochondrial unfolded protein response and FGF21 secretion in MASLD progression and the effect of exercise intervention Scientific reports 2025-01-29 [PMID: 39881157] (Mouse)
• Moharamzadeh, S;Kashef, M;Salehpour, M;Torabi, M;Vesali, S;Samsonchi, Z;Hajizadeh-Saffar, E; Effects of exercise intensity and diet on cardiac tissue structure and FGF21/?-Klotho signaling in type 2 diabetic mice: a comparative study of HFD and HFD?+?STZ induced type 2 diabetes models in mice Diabetology & metabolic syndrome 2025-01-06 [PMID: 39757236] (Mouse)
• Hua, L;Yang, Y;Zhang, H;Jiang, X;Jin, C;Feng, B;Che, L;Xu, S;Lin, Y;Wu, D;Zhuo, Y; Adipocyte FGF21 Signaling Defect Aggravated Adipose Tissue Inflammation in Gestational Diabetes Mellitus Nutrients 2024-11-07 [PMID: 39599611] (Mouse)
• Slattery, JD;Rambousek, JR;Tsui, E;Honeycutt, MK;Goldberg, M;Graham, JL;Wietecha, TA;Wolden-Hanson, T;O'Brien, KD;Havel, PJ;Blevins, JE; Effects of systemic oxytocin and beta-3 receptor agonist (CL 316243) treatment on body weight and adiposity in male diet-induced obese rats bioRxiv : the preprint server for biology 2024-09-30 [PMID: 39502365] (Rat)
• Yang, X;Chen, H;Shen, W;Chen, Y;Lin, Z;Zhuo, J;Wang, S;Yang, M;Li, H;He, C;Zhang, X;Hu, Z;Lian, Z;Yang, M;Wang, R;Li, C;Pan, B;Xu, L;Chen, J;Wei, X;Wei, Q;Xie, H;Zheng, S;Lu, D;Xu, X; FGF21 modulates immunometabolic homeostasis via the ALOX15/15-HETE axis in early liver graft injury Nature communications 2024-10-03 [PMID: 39362839] (Mouse, Transgenic Mouse)
• Molica, F;Ehrlich, A;Pelli, G;Rusiecka, OM;Montessuit, C;Chanson, M;Kwak, BR; Cold Exposure Rejuvenates the Metabolic Phenotype of Panx1-/- Mice Biomolecules 2024-08-25 [PMID: 39334824] (Transgenic Mouse)
• Cao, Y;Araki, M;Nakagawa, Y;Deisen, L;Lundsgaard, A;Kanta, JM;Holm, S;Johann, K;Brings Jacobsen, JC;Jähnert, M;Schürmann, A;Kiens, B;Clemmensen, C;Shimano, H;Fritzen, AM;Kleinert, M; Dietary Medium-Chain Fatty Acids Reduce Hepatic Fat Accumulation via Activation of a CREBH-FGF21 axis Molecular metabolism 2024-07-15 [PMID: 39019116] (Mouse, Transgenic Mouse)
• Mann, CG;MacArthur, MR;Zhang, J;Gong, S;AbuSalim, JE;Hunter, CJ;Lu, W;Agius, T;Longchamp, A;Allagnat, F;Rabinowitz, J;Mitchell, JR;De Bock, K;Mitchell, SJ; Sulfur Amino Acid Restriction Enhances Exercise Capacity in Mice by Boosting Fat Oxidation in Muscle bioRxiv : the preprint server for biology 2024-07-01 [PMID: 39005372] (Mouse, Transgenic Mouse)
• Agius, T;Emsley, R;Lyon, A;MacArthur, MR;Kiesworo, K;Faivre, A;Stavart, L;Lambelet, M;Legouis, D;de Seigneux, S;Golshayan, D;Lazeyras, F;Yeh, H;Markmann, JF;Uygun, K;Ocampo, A;Mitchell, SJ;Allagnat, F;Déglise, S;Longchamp, A; Short-term hypercaloric carbohydrate loading increases surgical stress resilience by inducing FGF21 Nature communications 2024-02-05 [PMID: 38316771] (Mouse)
• Kincaid, JWR;Rimmington, D;Tadross, JA;Cimino, I;Zvetkova, I;Kaser, A;Richards, P;Patel, S;O'Rahilly, S;Coll, AP; The gastrointestinal tract is a major source of the acute metformin-stimulated rise in GDF15 Scientific reports 2024-01-22 [PMID: 38253650] (Mouse)
• Trautman, ME;Braucher, LN;Elliehausen, C;Zhu, WG;Zelenovskiy, E;Green, M;Sonsalla, MM;Yeh, CY;Hornberger, TA;Konopka, AR;Lamming, DW; Resistance exercise protects mice from protein-induced fat accretion eLife 2023-11-29 [PMID: 38019262] (Mouse)
• Andres-Hernando, A;Orlicky, DJ;Kuwabara, M;Cicerchi, C;Pedler, M;Petrash, MJ;Johnson, RJ;Tolan, DR;Lanaspa, MA; Endogenous Fructose Production and Metabolism Drive Metabolic Dysregulation and Liver Disease in Mice with Hereditary Fructose Intolerance Nutrients 2023-10-16 [PMID: 37892451] (Mouse)
• Xu, J;Shao, X;Zeng, H;Wang, C;Li, J;Peng, X;Zhuo, Y;Hua, L;Meng, F;Han, X; Hepatic-Specific FGF21 Knockout Abrogates Ovariectomy-Induced Obesity by Reversing Corticosterone Production International journal of molecular sciences 2023-10-05 [PMID: 37834368] (Mouse)
• Minami, S;Sakai, S;Yamamoto, T;Takabatake, Y;Namba-Hamano, T;Takahashi, A;Matsuda, J;Yonishi, H;Nakamura, J;Maeda, S;Matsui, S;Matsui, I;Isaka, Y; FGF21 and autophagy coordinately counteract kidney disease progression during aging and obesity Autophagy 2023-09-18 [PMID: 37722816] (Mouse)
• Pham, TCP;Dollet, L;Ali, MS;Raun, SH;Møller, LLV;Jafari, A;Ditzel, N;Andersen, NR;Fritzen, AM;Gerhart-Hines, Z;Kiens, B;Suomalainen, A;Simpson, SJ;Salling Olsen, M;Kieser, A;Schjerling, P;Nieminen, AI;Richter, EA;Havula, E;Sylow, L; TNIK is a conserved regulator of glucose and lipid metabolism in obesity Science advances 2023-08-09 [PMID: 37556547] (Mouse)
• Vankrunkelsven, W;Thiessen, S;Derde, S;Vervoort, E;Derese, I;Pintelon, I;Matheussen, H;Jans, A;Goossens, C;Langouche, L;Van den Berghe, G;Vanhorebeek, I; Development of muscle weakness in a mouse model of critical illness: does fibroblast growth factor 21 play a role? Skeletal muscle 2023-08-04 [PMID: 37537627] (Mouse)
• Munoz, MD;Zamudio, A;McCann, M;Gil, V;Xu, P;Liew, CW; Activation of brown adipose tissue by a low-protein diet ameliorates hyperglycemia in a diabetic lipodystrophy mouse model Scientific reports 2023-07-21 [PMID: 37479751] (Mouse)
• Klein Hazebroek, M;Laterveer, R;Kutschke, M;Ramšak Mar?eta, V;Barthem, CS;Keipert, S; Hyperphagia of female UCP1-deficient mice blunts anti-obesity effects of FGF21 Scientific reports 2023-06-24 [PMID: 37355753] (Mouse)
• Southwell, N;Primiano, G;Nadkarni, V;Attarwala, N;Beattie, E;Miller, D;Alam, S;Liparulo, I;Shurubor, YI;Valentino, ML;Carelli, V;Servidei, S;Gross, SS;Manfredi, G;Chen, Q;D'Aurelio, M; A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy EMBO molecular medicine 2023-05-24 [PMID: 37222423] (Mouse)
• M Munoz, A Zamudio, M McCann, V Gil, P Xu, CW Liew Activation of brown adipose tissue by a low-protein diet ameliorates hyperglycemia in a diabetic lipodystrophy mouse model Research square, 2023-03-31;0(0):. 2023-03-31 [PMID: 37034803] (Mouse)
• JY Sun, LJ Du, XR Shi, YY Zhang, Y Liu, YL Wang, BY Chen, T Liu, H Zhu, Y Liu, CC Ruan, Z Gan, H Ying, Z Yin, PJ Gao, X Yan, RG Li, SZ Duan An IL-6/STAT3/MR/FGF21 axis mediates heart-liver cross-talk after myocardial infarction Science Advances, 2023-04-05;9(14):eade4110. 2023-04-05 [PMID: 37018396] (Mouse)
• M Baghdadi, T Nespital, A Mesaros, S Buschbaum, DJ Withers, S Grönke, L Partridge Reduced insulin signaling in neurons induces sex-specific health benefits Science Advances, 2023-02-22;9(8):eade8137. 2023-02-22 [PMID: 36812323] (Mouse)
• A Kogot-Levi, Y Riahi, I Abramovich, O Mosenzon, B Agranovich, L Kadosh, R Ben-Harous, D Kleiman, L Hinden, E Cerasi, D Ben-Zvi, E Bernal-Miz, J Tam, E Gottlieb, G Leibowitz Mapping the metabolic reprogramming induced by sodium-glucose cotransporter 2 inhibition JCI Insight, 2023-04-10;0(0):. 2023-04-10 [PMID: 36809274] (Mouse)
• CY Yeh, LCS Chini, MS Gallagher, JW Davidson, IT Freichels, MF Calubag, AC Rodgers, CL Green, R Babygirija, MM Sonsalla, HH Pak, M Trautman, TA Hacker, J Simcox, DW Lamming Restricting dietary protein or dietary isoleucine improves metabolic health in aged mice bioRxiv : the preprint server for biology, 2023-02-07;0(0):. 2023-02-07 [PMID: 36798157] (Mouse)
• X Gao, X Sun, H Cheng, JJ Ruzbarsky, M Mullen, M Huard, J Huard MRL/MpJ Mice Resist to Age-Related and Long-Term Ovariectomy-Induced Bone Loss: Implications for Bone Regeneration and Repair International Journal of Molecular Sciences, 2023-01-25;24(3):. 2023-01-25 [PMID: 36768718] (Mouse)
• X Gao, X Sun, H Cheng, JJ Ruzbarsky, M Mullen, M Huard, J Huard MRL/MpJ Mice Resist to Age-Related and Long-Term Ovariectomy-Induced Bone Loss: Implications for Bone Regeneration and Repair International Journal of Molecular Sciences, 2023;24(3):. 2023 [PMID: 36768718] (Mouse)
• T Hirabayash, M Kawaguchi, S Harada, M Mouri, R Takamiya, Y Miki, H Sato, Y Taketomi, K Yokoyama, T Kobayashi, SM Tokuoka, Y Kita, E Yoda, S Hara, K Mikami, Y Nishito, N Kikuchi, R Nakata, M Kaneko, H Kiyonari, K Kasahara, T Aiba, K Ikeda, T Soga, M Kurano, Y Yatomi, M Murakami Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups Cell Reports, 2023-01-30;42(2):111940. 2023-01-30 [PMID: 36719796] (Mouse)
• B Lee, HJ An, DH Kim, MK Lee, HH Jeong, KW Chung, Y Go, AY Seo, IY Kim, JK Seong, BP Yu, J Lee, E Im, IK Lee, MS Lee, KI Yamada, HY Chung SMP30-mediated synthesis of vitamin C activates the liver PPARalpha/FGF21 axis to regulate thermogenesis in mice Experimental & Molecular Medicine, 2022-11-25;0(0):. 2022-11-25 [PMID: 36434042] (Transgenic Mouse)
• T Mizumoto, T Yoshizawa, Y Sato, T Ito, T Tsuyama, A Satoh, S Araki, K Tsujita, M Tamura, Y Oike, K Yamagata SIRT7 Deficiency Protects against Aging-Associated Glucose Intolerance and Extends Lifespan in Male Mice Cells, 2022-11-15;11(22):. 2022-11-15 [PMID: 36429037] (Mouse)
• S Hokari, S Chikahisa, T Shiuchi, Y Nakayama, M Konishi, S Nishino, N Itoh, H Séi Social stress alters sleep in FGF21-deficient mice Brain research bulletin, 2022-10-13;0(0):. 2022-10-13 [PMID: 36243208] (Mouse)
• S Patel, A Haider, A Alvarez-Gu, G Bidault, JS El-Sayed M, E Guiu-Jurad, JA Tadross, J Warner, J Harrison, S Virtue, F Scurria, I Zvetkova, M Blüher, KS Small, S O'Rahilly, DB Savage Combined genetic deletion of GDF15 and FGF21 has modest effects on body weight, hepatic steatosis and insulin resistance in high fat fed mice Molecular Metabolism, 2022-09-02;65(0):101589. 2022-09-02 [PMID: 36064109] (Mouse)
• MR MacArthur, SJ Mitchell, KS Chadaideh, JH Treviño-Vi, J Jung, KC Kalafut, JS Reynolds, CG Mann, KM Trocha, M Tao, TZ Aye Cho, A Koontanate, V Yeliseyev, L Bry, A Longchamp, CK Ozaki, CA Lewis, RN Carmody, JR Mitchell Multiomics assessment of dietary protein titration reveals altered hepatic glucose utilization Cell Reports, 2022-08-16;40(7):111187. 2022-08-16 [PMID: 35977507] (Mouse)
• Z Zhang, P Diao, X Zhang, T Nakajima, T Kimura, N Tanaka Clinically Relevant Dose of Pemafibrate, a Novel Selective Peroxisome Proliferator-Activated Receptor alpha Modulator (SPPARMalpha), Lowers Serum Triglyceride Levels by Targeting Hepatic PPARalpha in Mice Oncogene, 2022-07-11;10(7):. 2022-07-11 [PMID: 35884970] (Mouse)
• C Yanucil, D Kentrup, X Li, A Grabner, K Schramm, EC Martinez, J Li, I Campos, B Czaya, K Heitman, D Westbrook, AR Wende, A Sloan, JM Roche, A Fornoni, MS Kapiloff, C Faul FGF21-FGFR4 signaling in cardiac myocytes promotes concentric cardiac hypertrophy in mouse models of diabetes Scientific Reports, 2022-05-05;12(1):7326. 2022-05-05 [PMID: 35513431] (Mouse)
• M Croon, K Szczepanow, M Popovic, C Lienkamp, K Senft, CP Brandschei, T Bock, L Gnatzy-Fei, A Ashurov, RJ Acton, H Kaul, C Pujol, S Rosenkranz, M Krüger, A Trifunovic FGF21 modulates mitochondrial stress response in cardiomyocytes only under mild mitochondrial dysfunction Science Advances, 2022-04-06;8(14):eabn7105. 2022-04-06 [PMID: 35385313] (Transgenic Mouse)
• L Morató, S Astori, I Zalachoras, J Rodrigues, S Ghosal, W Huang, I Guillot de, J Grosse, O Zanoletti, L Cao, J Auwerx, C Sandi eNAMPT actions through nucleus accumbens NAD+/SIRT1 link increased adiposity with sociability deficits programmed by peripuberty stress Science Advances, 2022-03-02;8(9):eabj9109. 2022-03-02 [PMID: 35235362] (Mouse)
• D Sáenz de U, X Buqué, B Porteiro, C Folgueira, A Mora, TC Delgado, E Prieto-Fer, P Olaizola, B Gómez-Sant, M Apodaka-Bi, F González-R, A Nieva-Zulu, M Ruiz de Ga, N Goikoetxea, JL García-Rod, V Gutierrez, I Aurrekoetx, V Montalvo-R, EM Novoa, I Martín-Gue, M Varela-Rey, S Bhanot, R Lee, JM Banales, WK Syn, G Sabio, ML Martínez-C, R Nogueiras, P Aspichueta Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis Nature Communications, 2022-03-01;13(1):1096. 2022-03-01 [PMID: 35232994] (Mouse)
• R Tagawa, M Kobayashi, M Sakurai, M Yoshida, H Kaneko, Y Mizunoe, Y Nozaki, N Okita, Y Sudo, Y Higami Long-Term Dietary Taurine Lowers Plasma Levels of Cholesterol and Bile Acids International Journal of Molecular Sciences, 2022-02-04;23(3):. 2022-02-04 [PMID: 35163722] (Mouse)
• A Rajna, LH Brown, SM Frangos, M Gonzalez-S, B Hucik, C Wang, DC Wright, DM Mutch Plant and marine N3-PUFA regulation of fatty acid trafficking along the adipose tissue-liver axis varies according to nutritional state The Journal of nutritional biochemistry, 2022-01-10;102(0):108940. 2022-01-10 [PMID: 35017005] (Mouse)
• SM Romanelli, KT Lewis, A Nishii, AC Rupp, Z Li, H Mori, RL Schill, BS Learman, CJ Rhodes, OA MacDougald BAd-CRISPR: inducible gene knockout in interscapular brown adipose tissue of adult mice The Journal of Biological Chemistry, 2021-11-11;0(0):101402. 2021-11-11 [PMID: 34774798] (Mouse)
• L Doridot, SA Hannou, SA Krawczyk, W Tong, MS Kim, GS McElroy, AJ Fowler, II Astapova, MA Herman A Systems Approach Dissociates Fructose-Induced Liver Triglyceride from Hypertriglyceridemia and Hyperinsulinemia in Male Mice Nutrients, 2021-10-18;13(10):. 2021-10-18 [PMID: 34684643] (Mouse)
• EC Lien, AM Westermark, Y Zhang, C Yuan, Z Li, AN Lau, KM Sapp, BM Wolpin, MG Vander Hei Low glycaemic diets alter lipid metabolism to influence tumour growth Nature, 2021-10-20;0(0):. 2021-10-20 [PMID: 34671163] (Human)
• K Kurup, SN Mann, J Jackson, S Matyi, M Ranjo-Bish, WM Freeman, MB Stout, A Richardson, A Unnikrishn Litter expansion alters metabolic homeostasis in a sex specific manner PLoS ONE, 2021-09-29;16(9):e0237199. 2021-09-29 [PMID: 34587168] (Mouse)
• MM Edwards, HK Nguyen, AD Dodson, AJ Herbertson, TA Wietecha, T Wolden-Han, JL Graham, MK Honeycutt, JD Slattery, KD O'Brien, PJ Havel, JE Blevins Effects of Combined Oxytocin and Beta-3 Receptor Agonist (CL 316243) Treatment on Body Weight and Adiposity in Male Diet-Induced Obese Rats Frontiers in Physiology, 2021-09-08;12(0):725912. 2021-09-08 [PMID: 34566687] (Rat)
• PM Rusu, AY Chan, M Heikenwald, OJ Müller, AJ Rose Dietary Essential Amino Acid Restriction Promotes Hyperdipsia via Hepatic FGF21 Nutrients, 2021-04-26;13(5):. 2021-04-26 [PMID: 33926065] (Mouse)
• B Grases-Pin, M Abril-Gil, P Torres-Cas, M Castell, MJ Rodríguez-, FJ Pérez-Cano, À Franch Rat Milk and Plasma Immunological Profile throughout Lactation Nutrients, 2021-04-11;13(4):. 2021-04-11 [PMID: 33920419] (Rat)
• AR Cox, N Chernis, KH Kim, PM Masschelin, PK Saha, SM Briley, R Sharp, X Li, JB Felix, Z Sun, DD Moore, SA Pangas, SM Hartig Ube2i deletion in adipocytes causes lipoatrophy in mice Molecular Metabolism, 2021-03-24;0(0):101221. 2021-03-24 [PMID: 33771728] (Mouse)
• O Stöhr, R Tao, J Miao, KD Copps, MF White FoxO1 suppresses Fgf21 during hepatic insulin resistance to impair peripheral glucose utilization and acute cold tolerance Cell Reports, 2021-03-23;34(12):108893. 2021-03-23 [PMID: 33761350] (Mouse)
• MJ Kim, D Febbraro, S Farkona, T Gillmore, JE Son, R Regeenes, HH Chang, E Pollock-Ta, J Yang, YJ Park, T Sivasubram, SJ Oh, P Saraon, I Stagljar, JV Rocheleau, CC Hui, I Caniggia, Z Hao, TW Mak, A Konvalinka, M Woo Distinct roles of UVRAG and EGFR signaling in skeletal muscle homeostasis Molecular Metabolism, 2021-02-06;47(0):101185. 2021-02-06 [PMID: 33561544] (Mouse)
• ES Selen, J Choi, MJ Wolfgang Discordant hepatic fatty acid oxidation and triglyceride hydrolysis leads to liver disease JCI Insight, 2021-01-25;6(2):. 2021-01-25 [PMID: 33491665] (Transgenic Mouse)
• SJ Burke, JL Taylor, HM Batdorf, RC Noland, DH Burk, Y Yu, ZE Floyd, JJ Collier The Ubiquitin Ligase SIAH2 Negatively Regulates Glucocorticoid Receptor Activity and Abundance Biomedicines, 2020-12-30;9(1):. 2020-12-30 [PMID: 33396678] (Mouse)
• JM Cho, EH Yang, W Quan, EH Nam, HG Cheon Discovery of a novel fibroblast activation protein (FAP) inhibitor, BR103354, with anti-diabetic and anti-steatotic effects Scientific Reports, 2020-12-04;10(1):21280. 2020-12-04 [PMID: 33277568] (Mouse)
• Y Nakagawa, Y Wang, SI Han, K Okuda, A Oishi, Y Yagishita, K Kumagai, H Ohno, Y Osaki, Y Mizunoe, M Araki, Y Murayama, H Iwasaki, M Konishi, N Itoh, T Matsuzaka, H Sone, N Yamada, H Shimano Enterohepatic transcription factor CREB3L3 protects atherosclerosis via SREBP competitive inhibition Cell Mol Gastroenterol Hepatol, 2020-11-24;0(0):. 2020-11-24 [PMID: 33246135] (Mouse)
• MF Yueh, F He, C Chen, C Vu, A Tripathi, R Knight, M Karin, S Chen, RH Tukey Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease Proc Natl Acad Sci U S A, 2020-11-23;0(0):. 2020-11-23 [PMID: 33229553] (Mouse)
• JK Stockman, KM Anderson, MY Karris, CA Benson, K Tsuyuki, DA Granger, A Weber, M Ghosh The Role of Stress and Genital Immunity in Sexual Trauma and HIV Susceptibility Among Adolescent Girls and Adult Women (The THRIVE Study): Protocol for a Longitudinal Case-Control Study JMIR research protocols, 2020-12-07;9(12):e18190. 2020-12-07 [PMID: 32903198] (Mouse)
• YW Yap, PM Rusu, AY Chan, BC Fam, A Jungmann, SM Solon-Biet, CK Barlow, DJ Creek, C Huang, RB Schittenhe, B Morgan, D Schmoll, B Kiens, MDW Piper, M Heikenwäld, SJ Simpson, S Bröer, S Andrikopou, OJ Müller, AJ Rose Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution Nat Commun, 2020-06-09;11(1):2894. 2020-06-09 [PMID: 32518324] (Mouse)
• T Kroon, M Harms, S Maurer, L Bonnet, I Alexanders, A Lindblom, A Ahnmark, D Nilsson, P Gennemark, G O'Mahony, V Osinski, C McNamara, J Boucher PPAR&gamma and PPAR&alpha synergize to induce robust browning of white fat in�vivo Mol Metab, 2020-02-18;36(0):100964. 2020-02-18 [PMID: 32248079] (Mouse)
• N Hanzawa, K Hashimoto, X Yuan, K Kawahori, K Tsujimoto, M Hamaguchi, T Tanaka, Y Nagaoka, H Nishina, S Morita, I Hatada, T Yamada, Y Ogawa Targeted DNA demethylation of the Fgf21 promoter by CRISPR/dCas9-mediated epigenome editing Sci Rep, 2020-03-20;10(1):5181. 2020-03-20 [PMID: 32198422] (Mouse)
• TD Challa, DH Dapito, E Kulenkampf, E Kiehlmann, C Moser, L Straub, W Sun, C Wolfrum A Genetic Model to Study the Contribution of Brown and Brite Adipocytes to Metabolism Cell Rep, 2020-03-10;30(10):3424-3433.e4. 2020-03-10 [PMID: 32160547] (Mouse)
• S Dey, Z Cui, O Gavrilova, X Zhang, M Gassmann, CT Noguchi Sex-specific brain erythropoietin regulation of mouse metabolism and hypothalamic inflammation JCI Insight, 2020-03-12;5(5):. 2020-03-12 [PMID: 32078583] (Mouse)
• Y Zhao, MF Zhao, S Jiang, J Wu, J Liu, XW Yuan, D Shen, JZ Zhang, N Zhou, J He, L Fang, XT Sun, B Xue, CJ Li Liver governs adipose remodelling via extracellular vesicles in response to lipid overload Nat Commun, 2020-02-05;11(1):719. 2020-02-05 [PMID: 32024826] (Mouse)
• BK Min, CJ Oh, S Park, JM Lee, Y Go, BY Park, HJ Kang, DW Kim, JE Kim, EK Yoo, HE Kim, MJ Kim, YH Jeon, YH Kim, CH Lee, JH Jeon, IK Lee Therapeutic effect of dichloroacetate against atherosclerosis via hepatic FGF21 induction mediated by acute AMPK activation Exp. Mol. Med., 2019-09-30;51(10):114. 2019-09-30 [PMID: 31570705] (Mouse)
• D Flicker, Y Sancak, E Mick, O Goldberger, VK Mootha Exploring the In�Vivo Role of the Mitochondrial Calcium Uniporter in Brown Fat Bioenergetics Cell Rep, 2019-04-30;27(5):1364-1375.e5. 2019-04-30 [PMID: 31042465] (Mouse)
• PMM Ruppert, JG Park, X Xu, KY Hur, AH Lee, S Kersten Transcriptional profiling of PPAR?-/- and CREB3L3-/- livers reveals disparate regulation of hepatoproliferative and metabolic functions of PPAR? BMC Genomics, 2019-03-11;20(1):199. 2019-03-11 [PMID: 30866796] (Mouse)
• YD Kim, SL Hwang, HJ Jeon, YH Jeon, B Nedumaran, K Kim, SE Lee B-cell translocation gene 2 enhances fibroblast growth factor 21 production by inducing Kruppel-like factor 15 Sci Rep, 2019-03-06;9(1):3730. 2019-03-06 [PMID: 30842568] (Mouse)
• J Liu, K Yang, J Yang, W Xiao, Y Le, F Yu, L Gu, S Lang, Q Tian, T Jin, R Wei, T Hong Liver-derived fibroblast growth factor 21 mediates effects of glucagon-like peptide-1 in attenuating hepatic glucose output EBioMedicine, 2019-03-01;0(0):. 2019-03-01 [PMID: 30827929] (Mouse)
• Y Zhuo, L Hua, B Feng, X Jiang, J Li, D Jiang, X Huang, Y Zhu, Z Li, L Yan, C Jin, L Che, Z Fang, Y Lin, S Xu, J Li, Wu Fibroblast growth factor 21 coordinates adiponectin to mediate the beneficial effects of low-protein diet on primordial follicle reserve EBioMedicine, 2019-02-13;41(0):623-635. 2019-02-13 [PMID: 30772303] (Mouse)
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• CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPAR? Sci Rep, 2016-12-16;6(0):39182. 2016-12-16 [PMID: 27982131] (Mouse)
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• The Orphan Nuclear Receptor ERR? Regulates Hepatic CB1 Receptor-Mediated Fibroblast Growth Factor 21 Gene Expression PLoS ONE, 2016-07-25;11(7):e0159425. 2016-07-25 [PMID: 27455076] (Mouse)
• Jong-Ho Kim Intramyocardial Adipose-Derived Stem Cell Transplantation Increases Pericardial Fat with Recovery of Myocardial Function after Acute Myocardial Infarction PLoS ONE, 2016-06-23;11(6):e0158067. 2016-06-23 [PMID: 27336402] (Mouse)
• Tsutomu Hashidume Single ingestion of soy ?-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects Sci Rep, 2016-06-17;6(0):28183. 2016-06-17 [PMID: 27312476] (Mouse)
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• Yoshimi Nakagawa Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system Sci Rep, 2016-06-13;6(0):27857. 2016-06-13 [PMID: 27291420] (Mouse)
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• Domouzoglou , Eleni M, Fisher , Ffolliot, Astapova , Inna, Fox , Elliott, Kharitonenkov , Alexei, Flier , Jeffrey, Hollenberg , Anthony, Maratos-Flier , Elefther Fibroblast growth factor 21 and thyroid hormone show mutual regulatory dependency but have independent actions in vivo. Endocrinology, 2014-02-24;155(5):2031-40. 2014-02-24 [PMID: 24564398] (Mouse)
• Pando , Rakefet, Shtaif , Biana, Phillip , Moshe, Gat-Yablonski , Galia A serum component mediates food restriction-induced growth attenuation. Endocrinology, 2014-01-23;155(3):932-40. 2014-01-23 [PMID: 24456162] (Rat)
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• Ahlqvist KJ, Hamalainen RH, Yatsuga S, Uutela M, Terzioglu M, Gotz A, Forsstrom S, Salven P, Angers-Loustau A, Kopra OH, Tyynismaa H, Larsson NG, Wartiovaara K, Prolla T, Trifunovic A, Suomalainen A Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice. Cell Metab., 2012-01-04;15(1):100-9. 2012-01-04 [PMID: 22225879] (Mouse)
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Bioinformatics

• Gene Symbol: Fgf21