Mouse/Rat FGF-21 Quantikine ELISA Kit

Product Details

Summary
Reactivity Mu, RtSpecies Glossary
Applications ELISA
Conjugate
HRP

Order Details

Mouse/Rat FGF-21 Quantikine ELISA Kit Summary

Background
The Quantikine Mouse/Rat FGF-21 immunoassay is a 4.5 hour solid-phase ELISA designed to measure FGF-21 in mouse or rat cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant mouse FGF-21 and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant mouse FGF-21. Results obtained using natural mous...e or rat FGF-21 showed dose response curves that were parallel to the standard curves obtained using the Quantikine mouse kit standards. These results indicate that this kit can be used to determine relative mass values for natural FGF-21.
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Specificity
Natural and recombinant mouse and rat FGF-21
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
Fgf21

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using MF2100.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse/Rat FGF-21 Quantikine ELISA Kit

  • FGF21
  • FGF-21
  • fibroblast growth factor 21

Background

FGF-21 (Fibroblast Growth Factor 21) is a member of an FGF subfamily that also includes FGF-19 and FGF-23. FGF-19 subfamily members lack a heparin binding domain, enabling them to freely circulate as endocrine factors and diffuse within tissues. FGF-21 signals through Klotho beta in complex with FGF receptors. It regulates cellular metabolism including glucose uptake in adipocytes and cellular sensitivity to insulin. It is basally expressed in the pancreas, thymus, liver, and adipose tissue and is upregulated in liver, muscle, and fat in obesity and diabetes. FGF-21 also plays a role in cell survival and proliferation, mesenchymal stem cell differentiation, circadian rhythm, and controlling reproductive capacity.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for FGF-21 (MF2100)(110)

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Transgenic Mouse.


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Human
(2)
Mouse
(95)
Rat
(10)
Transgenic Mouse
(3)
All Species
Showing Publications 1 - 10 of 110. Show All 110 Publications.
Publications using MF2100 Applications Species
Minami, S;Sakai, S;Yamamoto, T;Takabatake, Y;Namba-Hamano, T;Takahashi, A;Matsuda, J;Yonishi, H;Nakamura, J;Maeda, S;Matsui, S;Matsui, I;Isaka, Y; FGF21 and autophagy coordinately counteract kidney disease progression during aging and obesity Autophagy 2023-09-18 [PMID: 37722816] (Mouse) Mouse
Pham, TCP;Dollet, L;Ali, MS;Raun, SH;Møller, LLV;Jafari, A;Ditzel, N;Andersen, NR;Fritzen, AM;Gerhart-Hines, Z;Kiens, B;Suomalainen, A;Simpson, SJ;Salling Olsen, M;Kieser, A;Schjerling, P;Nieminen, AI;Richter, EA;Havula, E;Sylow, L; TNIK is a conserved regulator of glucose and lipid metabolism in obesity Science advances 2023-08-09 [PMID: 37556547] (Mouse) Mouse
Klein Hazebroek, M;Laterveer, R;Kutschke, M;Ramšak Mar?eta, V;Barthem, CS;Keipert, S; Hyperphagia of female UCP1-deficient mice blunts anti-obesity effects of FGF21 Scientific reports 2023-06-24 [PMID: 37355753] (Mouse) Mouse
Southwell, N;Primiano, G;Nadkarni, V;Attarwala, N;Beattie, E;Miller, D;Alam, S;Liparulo, I;Shurubor, YI;Valentino, ML;Carelli, V;Servidei, S;Gross, SS;Manfredi, G;Chen, Q;D'Aurelio, M; A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy EMBO molecular medicine 2023-05-24 [PMID: 37222423] (Mouse) Mouse
M Munoz, A Zamudio, M McCann, V Gil, P Xu, CW Liew Activation of brown adipose tissue by a low-protein diet ameliorates hyperglycemia in a diabetic lipodystrophy mouse model Research square, 2023-03-31;0(0):. 2023-03-31 [PMID: 37034803] (Mouse) Mouse
JY Sun, LJ Du, XR Shi, YY Zhang, Y Liu, YL Wang, BY Chen, T Liu, H Zhu, Y Liu, CC Ruan, Z Gan, H Ying, Z Yin, PJ Gao, X Yan, RG Li, SZ Duan An IL-6/STAT3/MR/FGF21 axis mediates heart-liver cross-talk after myocardial infarction Science Advances, 2023-04-05;9(14):eade4110. 2023-04-05 [PMID: 37018396] (Mouse) Mouse
M Baghdadi, T Nespital, A Mesaros, S Buschbaum, DJ Withers, S Grönke, L Partridge Reduced insulin signaling in neurons induces sex-specific health benefits Science Advances, 2023-02-22;9(8):eade8137. 2023-02-22 [PMID: 36812323] (Mouse) Mouse
A Kogot-Levi, Y Riahi, I Abramovich, O Mosenzon, B Agranovich, L Kadosh, R Ben-Harous, D Kleiman, L Hinden, E Cerasi, D Ben-Zvi, E Bernal-Miz, J Tam, E Gottlieb, G Leibowitz Mapping the metabolic reprogramming induced by sodium-glucose cotransporter 2 inhibition JCI Insight, 2023-04-10;0(0):. 2023-04-10 [PMID: 36809274] (Mouse) Mouse
CY Yeh, LCS Chini, MS Gallagher, JW Davidson, IT Freichels, MF Calubag, AC Rodgers, CL Green, R Babygirija, MM Sonsalla, HH Pak, M Trautman, TA Hacker, J Simcox, DW Lamming Restricting dietary protein or dietary isoleucine improves metabolic health in aged mice bioRxiv : the preprint server for biology, 2023-02-07;0(0):. 2023-02-07 [PMID: 36798157] (Mouse) Mouse
X Gao, X Sun, H Cheng, JJ Ruzbarsky, M Mullen, M Huard, J Huard MRL/MpJ Mice Resist to Age-Related and Long-Term Ovariectomy-Induced Bone Loss: Implications for Bone Regeneration and Repair International Journal of Molecular Sciences, 2023-01-25;24(3):. 2023-01-25 [PMID: 36768718] (Mouse) Mouse
Show All 110 Publications.

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Bioinformatics

Gene Symbol Fgf21