Mouse/Rat CCL5/RANTES Quantikine ELISA Kit, 2 Plate

• Reactivity: Mu, Rt
• Applications: ELISA
• Conjugate: HRP

Mouse/Rat CCL5/RANTES Quantikine ELISA Kit, 2 Plate Summary

• Background: The Quantikine Mouse/Rat CCL5/RANTES Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse or rat RANTES levels in cell culture supernates, serum, and platelet-poor plasma. It contains E. coli-expressed recombinant mouse RANTES as well as antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate recombinant RANTES. Res...ults obtained using natural mouse or rat RANTES showed linear curves that were parallel to the standard curves obtained using the recombinant kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse and rat RANTES.
  Show More
• Specificity: Natural and recombinant mouse and rat RANTES. This assay cross-reacts 1.3% with recombinant Human RANTES.
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Ccl5

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse/Rat CCL5/RANTES Quantikine ELISA Kit, 2 Plate

• CCL5
• chemokine (C-C motif) ligand 5
• D17S136Enormally T-expressed, and presumably secreted
• EoCP
• Eosinophil chemotactic cytokine
• RANTES
• SISd
• SIS-delta
• small inducible cytokine A5 (RANTES)
• small inducible cytokine subfamily A (Cys-Cys), member 5
• Small-inducible cytokine A5
• T cell-specific protein P228
• T-cell specific protein p288
• TCP228T-cell-specific protein RANTES

Background

RANTES (Regulated upon Activation, Normal T cell-expressed, and presumably Secreted), also known as CCL5, a member of the CC chemokine family of inflammatory and immunoregulatory cytokines, initially discovered by subtractive hybridization as a T cell-specific molecule (1, 2). Mouse RANTES cDNA encodes a 91 amino acid (aa) residue precursor protein with a presumed signal peptide of 23 aa residues that is cleaved to generate the 68 aa residue mature protein (3). At the amino acid sequence level, mouse RANTES is 84% identical to human RANTES. Both human and mouse RANTES exhibit cross species activity. Naturally occurring human RANTES has been found to be a mixture of the 68 aa residue mature protein and a 66 aa residue amino-terminally truncated form (4, 5). Cells known to express RANTES include keratinocytes, eosinophils, platelets, endothelium, fibroblasts, respiratory epithelium, astrocytes, vascular smooth muscle, and CD4⁺ and CD8⁺ T cells (6-14). As suggested by its acronym, RANTES production by the various cell types is induced in response to cytokine stimulation (8-13). 

Like other CC chemokines, RANTES is a monocyte chemoattractant (2). RANTES can also chemoattract unstimulated CD4⁺/CD45RO⁺ memory T cells and stimulated CD4⁺ and CD8⁺ T cells with the naive and memory phenotypes. In addition, RANTES can chemoattract and degranulate eosinophils, as well as chemoattract and induce histamine release from basophils. Human RANTES has been shown to be an inhibitor of HIV infection of human mononuclear cells (15, 16). Several CC chemokine receptors, including CCR-1, CCR-3, CCR-4, and CCR-5, have been shown to bind RANTES and subsequently to transduce a signal by increasing the intracellular calcium ion level (2, 17-21).

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for CCL5/RANTES (MMR00)(96)

Publications using MMR00

• Chi, G;Lu, J;He, T;Wang, Y;Zhou, X;Zhang, Y;Qiu, L; High mobility group box-1 protein promotes astrocytic CCL5 production through the MAPK/NF-?B pathway following spinal cord injury Scientific reports 2024-09-27 [PMID: 39333662] (Rat)
• Lin, CY;Omoscharka, E;Liu, Y;Cheng, K; Establishment of a Rat Model of Alcoholic Liver Fibrosis with Simulated Human Drinking Patterns and Low-Dose Chemical Stimulation Biomolecules 2023-08-24 [PMID: 37759693] (Rat)
• Sha, L;Li, J;Shen, H;Wang, Q;Meng, P;Zhang, X;Deng, Y;Zhu, W;Xu, Q; LHPP-mediated inorganic pyrophosphate hydrolysis-driven lysosomal acidification in astrocytes regulates adult neurogenesis Cell reports 2023-08-11 [PMID: 37573508] (Mouse)
• Jadi, PK;Dave, A;Issa, R;Tabbasum, K;Okurowska, K;Samarth, A;Urwin, L;Green, LR;Partridge, LJ;MacNeil, S;Garg, P;Monk, PN;Roy, S; Tetraspanin CD9-derived peptides inhibit Pseudomonas aeruginosa corneal infection and aid in wound healing of corneal epithelial cells The ocular surface 2023-07-03 [PMID: 37406881] (Mouse)
• K Ann Shirey, W Lai, M Sunday, F Cuttitta, J Cg Blanco, SN Vogel Novel neuroendocrine role of gamma-aminobutyric acid and gastrin releasing peptide in the host response to influenza infection Mucosal Immunology, 2023-03-24;0(0):. 2023-03-24 [PMID: 36965691] (Mouse)
• H Watanabe, T Iori, JW Lee, TS Kajii, A Takakura, R Takao-Kawa, Y Kitagawa, Y Maruoka, T Iimura Association between an Increased Serum CCL5 Level and Pathophysiology of Degenerative Joint Disease in the Temporomandibular Joint in Females International Journal of Molecular Sciences, 2023-02-01;24(3):. 2023-02-01 [PMID: 36769097] (Rat)
• J Chatterjee, S Sanapala, O Cobb, A Bewley, AK Goldstein, E Cordell, X Ge, JR Garbow, MJ Holtzman, DH Gutmann Asthma reduces glioma formation by T cell decorin-mediated inhibition of microglia Nature Communications, 2021-12-08;12(1):7122. 2021-12-08 [PMID: 34880260] (Mouse)
• Y Liu, Y Zhao, Y Shukha, H Lu, L Wang, Z Liu, C Liu, Y Zhao, H Wang, G Zhao, W Liang, Y Fan, L Chang, A Yurdagul, CB Pattillo, AW Orr, M Aviram, B Wen, MT Garcia-Bar, J Zhang, W Liu, D Sun, T Hayek, YE Chen, O Rom Dysregulated oxalate metabolism is a driver and therapeutic target in atherosclerosis Cell Reports, 2021-07-27;36(4):109420. 2021-07-27 [PMID: 34320345] (Mouse)
• SJ Wu, CJ Liou, YL Chen, SC Cheng, WC Huang Fucoxanthin Ameliorates Oxidative Stress and Airway Inflammation in Tracheal Epithelial Cells and Asthmatic Mice Cells, 2021-05-25;10(6):. 2021-05-25 [PMID: 34070405] (Mouse)
• K Tajiri, K Imanaka-Yo, Y Tsujimura, K Matsuo, M Hiroe, K Aonuma, M Ieda, Y Yasutomi A New Mouse Model of Chronic Myocarditis Induced by Recombinant Bacille Calmette-Gu�rin Expressing a T-Cell Epitope of Cardiac Myosin Heavy Chain-&alpha International Journal of Molecular Sciences, 2021-01-14;22(2):. 2021-01-14 [PMID: 33466825] (Mouse)
• N Hagan, JL Kane, D Grover, L Woodworth, C Madore, J Saleh, J Sancho, J Liu, Y Li, J Proto, M Zelic, A Mahan, M Kothe, AA Scholte, M Fitzgerald, B Gisevius, A Haghikia, O Butovsky, D Ofengeim CSF1R signaling is a regulator of pathogenesis in progressive MS Cell Death Dis, 2020-10-23;11(10):904. 2020-10-23 [PMID: 33097690] (Mouse)
• DS Donaldson, BM Bradford, KJ Else, NA Mabbott Accelerated onset of CNS prion disease in mice co-infected with a gastrointestinal helminth pathogen during the preclinical phase Sci Rep, 2020-03-12;10(1):4554. 2020-03-12 [PMID: 32165661] (Mouse)
• JJ Merino, V Muñetón-Go, C Muñetón-Gó, MÁ Pérez-Izqu, M Loscertale, A Toledano G Hippocampal CCR5/RANTES Elevations in a Rodent Model of Post-Traumatic Stress Disorder: Maraviroc (a CCR5 Antagonist) Increases Corticosterone Levels and Enhances Fear Memory Consolidation Biomolecules, 2020-02-01;10(2):. 2020-02-01 [PMID: 32024104] (Rat)
• M Gasparitsc, A Schieber, T Schaubeck, U Keller, M Cattaruzza, B Lange-Sper Tyrphostin AG490 reduces inflammation and fibrosis in neonatal obstructive nephropathy PLoS ONE, 2019-12-17;14(12):e0226675. 2019-12-17 [PMID: 31846485] (Mouse)
• A Miyauchi, W Watanabe, T Akashi, S Hashiguchi, H Yoshida, C Sugita, M Kurokawa Effect of inactivated Streptococcus pneumoniae as non-pathogenic particles on the severity of pneumonia caused by respiratory syncytial virus infection in mice Toxicol Rep, 2019-05-31;6(0):514-520. 2019-05-31 [PMID: 31245279] (Mouse)
• SO Piryani, AYF Kam, UT Vu, NJ Chao, PL Doan CCR5 Signaling Promotes Murine and Human Hematopoietic Regeneration following Ionizing Radiation Stem Cell Reports, 2019-05-30;13(1):76-90. 2019-05-30 [PMID: 31155503] (Mouse)
• GM Yu, W Tan Melatonin Inhibits Lipopolysaccharide-Induced Inflammation and Oxidative Stress in Cultured Mouse Mammary Tissue Mediators Inflamm., 2019-02-12;2019(0):8597159. 2019-02-12 [PMID: 30890898] (Mouse)
• RL Openshaw, J Kwon, A McColl, JM Penninger, J Cavanagh, JA Pratt, BJ Morris JNK signalling mediates aspects of maternal immune activation: importance of maternal genotype in relation to schizophrenia risk J Neuroinflammation, 2019-01-28;16(1):18. 2019-01-28 [PMID: 30691477] (Mouse)
• L Qin, Y Du, H Ding, A Haque, J Hicks, C Pedroza, C Mohan Bradykinin 1 receptor blockade subdues systemic autoimmunity, renal inflammation, and blood pressure in murine lupus nephritis Arthritis Res. Ther., 2019-01-08;21(1):12. 2019-01-08 [PMID: 30621761] (Mouse)
• L Ritchie, R Tate, LH Chamberlai, G Robertson, M Zagnoni, T Sposito, S Wray, JA Wright, CE Bryant, NJ Gay, TJ Bushell Toll-like receptor 3 activation impairs excitability and synaptic activity via TRIF signalling in immature rat and human neurons Neuropharmacology, 2018-03-02;135(0):1-10. 2018-03-02 [PMID: 29505789] (Rat)
• IK Kim, K Kim, E Lee, DS Oh, CS Park, S Park, JM Yang, JH Kim, HS Kim, DT Shima, JH Kim, SH Hong, YH Cho, YH Kim, JB Park, GY Koh, YS Ju, HK Lee, S Lee, I Kim Sox7 promotes high-grade glioma by increasing VEGFR2-mediated vascular abnormality J. Exp. Med., 2018-02-14;0(0):. 2018-02-14 [PMID: 29444818] (ELISA Capture, Mouse)
• F Allen, ID Bobanga, P Rauhe, D Barkauskas, N Teich, C Tong, J Myers, AY Huang CCL3 augments tumor rejection and enhances CD8+T cell infiltration through NK and CD103+dendritic cell recruitment via IFN? Oncoimmunology, 2017-11-20;7(3):e1393598. 2017-11-20 [PMID: 29399390] (ELISA Capture, Mouse)
• L Szulc-D?br, J Struzik, A Ostrowska, M Guzera, FN Toka, M Bossowska-, MM Giery?ska, A Winnicka, Z Nowak, MG Niemia?tow Functional paralysis of GM-CSF-derived bone marrow cells productively infected with ectromelia virus PLoS ONE, 2017-06-12;12(6):e0179166. 2017-06-12 [PMID: 28604814] (Mouse)
• N Liu, L Xu, Y Shi, L Fang, H Gu, H Wang, X Ding, S Zhuang Pharmacologic targeting ERK1/2 attenuates the development and progression of hyperuricemic nephropathy in rats Oncotarget, 2017-05-16;8(20):33807-33826. 2017-05-16 [PMID: 28442634] (Rat)
• Y Pan, LJ Smithson, Y Ma, D Hambardzum, DH Gutmann Ccl5 establishes an autocrine high-grade glioma growth regulatory circuit critical for mesenchymal glioblastoma survival Oncotarget, 2017-05-16;0(0):. 2017-05-16 [PMID: 28380429] (Mouse)
• Soluble Fn14 Is Detected and Elevated in Mouse and Human Kidney Disease PLoS ONE, 2016-05-12;11(5):e0155368. 2016-05-12 [PMID: 27171494] (Mouse)
• Mishra , Amarjit, Brown , Alexandr, Yao , Xianglan, Yang , Shutong, Park , Sung-Jun, Liu , Chengyu, Dagur , Pradeep, McCoy , J Philip, Keeran , Karen J, Nugent , Gayle Z, Jeffries , Kenneth, Qu , Xuan, Yu , Zu-Xi, Levine , Stewart, Chung , Jay H Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase. Nat Commun, 2015-02-18;6(0):6224. 2015-02-18 [PMID: 25692509] (Mouse)
• Lee E, Fertig E, Jin K, Sukumar S, Pandey N, Popel A Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis. Nat Commun, 2014-09-02;5(0):4715. 2014-09-02 [PMID: 25178650] (Mouse)
• Saha A, Biswas A, Srivastav S, Mukherjee M, Das P, Ukil A Prostaglandin E2 negatively regulates the production of inflammatory cytokines/chemokines and IL-17 in visceral leishmaniasis. J Immunol, 2014-07-21;193(5):2330-9. 2014-07-21 [PMID: 25049356] (Mouse)
• Aeffner F, Woods P, Davis I Activation of A1-adenosine receptors promotes leukocyte recruitment to the lung and attenuates acute lung injury in mice infected with influenza A/WSN/33 (H1N1) virus. J Virol, 2014-06-25;88(17):10214-27. 2014-06-25 [PMID: 24965449] (Mouse)
• Cekanaviciute E, Dietrich H, Axtell R, Williams A, Egusquiza R, Wai K, Koshy A, Buckwalter M Astrocytic TGF-beta signaling limits inflammation and reduces neuronal damage during central nervous system Toxoplasma infection. J Immunol, 2014-05-23;193(1):139-49. 2014-05-23 [PMID: 24860191] (Mouse)
• Brenndorfer E, Brass A, Karthe J, Ahlen G, Bode J, Sallberg M Cleavage of the T cell protein tyrosine phosphatase by the hepatitis C virus nonstructural 3/4A protease induces a Th1 to Th2 shift reversible by ribavirin therapy. J Immunol, 2014-01-17;192(4):1671-80. 2014-01-17 [PMID: 24442435] (Mouse)
• Blonder J, Mutka S, Sun X, Qiu J, Green L, Mehra N, Boyanapalli R, Suniga M, Look K, Delany C, Richards J, Looker D, Scoggin C, Rosenthal G Pharmacologic inhibition of S-nitrosoglutathione reductase protects against experimental asthma in BALB/c mice through attenuation of both bronchoconstriction and inflammation. BMC Pulm Med, 2014-01-10;14(0):3. 2014-01-10 [PMID: 24405692] (Mouse)
• Lin J, Sun B, Jiang C, Hong H, Zheng Y Sirt2 suppresses inflammatory responses in collagen-induced arthritis. Biochem Biophys Res Commun, 2013-11-06;441(4):897-903. 2013-11-06 [PMID: 24211200] (Mouse)
• Butchi N, Hinton D, Stohlman S, Kapil P, Fensterl V, Sen G, Bergmann C Ifit2 deficiency results in uncontrolled neurotropic coronavirus replication and enhanced encephalitis via impaired alpha/beta interferon induction in macrophages. J Virol, 2013-11-06;88(2):1051-64. 2013-11-06 [PMID: 24198415] (Mouse)
• Jiang E, Perrard X, Yang D, Khan I, Perrard J, Smith C, Ballantyne C, Wu H Essential role of CD11a in CD8+ T-cell accumulation and activation in adipose tissue. Arterioscler Thromb Vasc Biol, 2013-10-24;34(1):34-43. 2013-10-24 [PMID: 24158516] (Mouse)
• Guirnalda P, Wood L, Goenka R, Crespo J, Paterson Y Interferon gamma-induced intratumoral expression of CXCL9 alters the local distribution of T cells following immunotherapy with Oncoimmunology, 2013-07-23;2(8):e25752. 2013-07-23 [PMID: 24083082] (Mouse)
• Fukuyama Y, Tokuhara D, Sekine S, Aso K, Kataoka K, Davydova J, Yamamoto M, Gilbert R, Tokuhara Y, Fujihashi K, Kunisawa J, Yuki Y, Kiyono H, McGhee J, Fujihashi K Potential roles of CCR5(+) CCR6(+) dendritic cells induced by nasal ovalbumin plus Flt3 ligand expressing adenovirus for mucosal IgA responses. PLoS ONE, 2013-04-02;8(4):e60453. 2013-04-02 [PMID: 23565250] (Mouse)
• Watanabe S, Kumazawa Y, Inoue J Liposomal lipopolysaccharide initiates TRIF-dependent signaling pathway independent of CD14. PLoS ONE, 2013-04-02;8(4):e60078. 2013-04-02 [PMID: 23565187] (Mouse)
• Guo Z, Wen Z, Qin A, Zhou Y, Liao Z, Liu Z, Liang Y, Ren T, Xu L Antisense oligonucleotide treatment enhances the recovery of acute lung injury through IL-10-secreting M2-like macrophage-induced expansion of CD4+ regulatory T cells. J Immunol, 2013-03-20;190(8):4337-48. 2013-03-20 [PMID: 23514739] (Mouse)
• Kong H, Chen F, He Y, Wu L, Wang L, Zhu S, Zheng S Intrarenal resistance index for the assessment of acute renal injury in a rat liver transplantation model. BMC Nephrol, 2013-03-02;14(0):55. 2013-03-02 [PMID: 23453043] (Rat)
• Chen K, Chang C, Huang C, Lin C, Lin W, Lo Y, Yang C, Hsing E, Chen L, Shih S, Shiau A, Lei H, Tan T, Ling P TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity. J Biol Chem, 2012-07-25;287(38):32216-21. 2012-07-25 [PMID: 22833682] (Mouse)
• Gais P, Reim D, Jusek G, Rossmann-Bloeck T, Weighardt H, Pfeffer K, Altmayr F, Janssen KP, Holzmann B Cutting edge: Divergent cell-specific functions of MyD88 for inflammatory responses and organ injury in septic peritonitis. J. Immunol., 2012-05-14;188(12):5833-7. 2012-05-14 [PMID: 22586041] (Mouse)
• Decreased plasma cytokines are associated with low platelet counts in aplastic anemia and immune thrombocytopenic purpura. J. Thromb. Haemost., 2012-08-01;10(8):1616-23. 2012-08-01 [PMID: 22537155] (Mouse)
• Gottfries J, Melgar S, Michaelsson E Modelling of mouse experimental colitis by global property screens: a holistic approach to assess drug effects in inflammatory bowel disease. PLoS ONE, 2012-01-18;7(1):e30005. 2012-01-18 [PMID: 22279558] (Mouse)
• Fisher DT, Chen Q, Skitzki JJ, Muhitch JB, Zhou L, Appenheimer MM, Vardam TD, Weis EL, Passanese J, Wang WC, Gollnick SO, Dewhirst MW, Rose-John S, Repasky EA, Baumann H, Evans SS IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells. J. Clin. Invest., 2011-09-19;121(10):3846-59. 2011-09-19 [PMID: 21926464] (Mouse)
• Provoost S, Maes T, Joos GF, Tournoy KG Monocyte-derived dendritic cell recruitment and allergic T(H)2 responses after exposure to diesel particles are CCR2 dependent. J. Allergy Clin. Immunol., 2011-09-08;129(2):483-91. 2011-09-08 [PMID: 21906792] (Mouse)
• Yamamoto Y, Otani S, Hirai H, Nagata K, Aritake K, Urade Y, Narumiya S, Yokozeki H, Nakamura M, Satoh T Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2. Am. J. Pathol., 2011-05-10;179(1):302-14. 2011-05-10 [PMID: 21703412] (Mouse)
• Reim D, Rossmann-Bloeck T, Jusek G, Prazeres da Costa O, Holzmann B Improved host defense against septic peritonitis in mice lacking MyD88 and TRIF is linked to a normal interferon response. J. Leukoc. Biol., 2011-05-31;90(3):613-20. 2011-05-31 [PMID: 21628330] (Mouse)
• Besnard AG, Togbe D, Guillou N, Erard F, Quesniaux V, Ryffel B IL-33-activated dendritic cells are critical for allergic airway inflammation. Eur. J. Immunol., 2011-05-25;41(6):1675-86. 2011-05-25 [PMID: 21469105] (Mouse)
• Wang H, Cheng F Histone Deacetylase Inhibitor LAQ824 Augments Inflammatory Responses in Macrophages through Transcriptional Regulation of IL-10. J. Immunol., 2011-03-02;186(0):3986. 2011-03-02 [PMID: 21368229] (Mouse)
• Yasuoka S, Kawanokuchi J, Parajuli B, Jin S, Doi Y, Noda M, Sonobe Y, Takeuchi H, Mizuno T, Suzumura A Production and functions of IL-33 in the central nervous system. Brain Res., 2011-02-22;1385(0):8-17. 2011-02-22 [PMID: 21349253] (Mouse)
• Dorhoi A, Desel C, Yeremeev V, Pradl L, Brinkmann V, Mollenkopf HJ, Hanke K, Gross O, Ruland J, Kaufmann SH The adaptor molecule CARD9 is essential for tuberculosis control. J. Exp. Med., 2010-03-29;207(4):777-92. 2010-03-29 [PMID: 20351059] (Mouse)
• Liu PC, Caulder E, Li J, Waeltz P, Margulis A, Wynn R, Becker-Pasha M, Li Y, Crowgey E, Hollis G, Haley P, Sparks RB, Combs AP, Rodgers JD, Burn TC, Vaddi K, Fridman JS Combined inhibition of janus kinase 1/2 for the treatment of JAK2V617F-driven neoplasms: selective effects on mutant cells and improvements in measures of disease severity. Clin. Cancer Res., 2009-11-03;15(22):6891-900. 2009-11-03 [PMID: 19887489] (Mouse)
• Doodes PD, Cao Y, Hamel KM, Wang Y, Rodeghero RL, Kobezda T, Finnegan A CCR5 is involved in resolution of inflammation in proteoglycan-induced arthritis. Arthritis Rheum., 2009-10-01;60(10):2945-53. 2009-10-01 [PMID: 19790057] (Mouse)
• Herz J, Pardo J, Kashkar H, Schramm M, Kuzmenkina E, Bos E, Wiegmann K, Wallich R, Peters PJ, Herzig S, Schmelzer E, Kronke M, Simon MM, Utermohlen O Acid sphingomyelinase is a key regulator of cytotoxic granule secretion by primary T lymphocytes. Nat. Immunol., 2009-06-14;10(7):761-8. 2009-06-14 [PMID: 19525969] (Mouse)
• Gueders MM, Paulissen G, Crahay C, Quesada-Calvo F, Hacha J, Van Hove C, Tournoy K, Louis R, Foidart JM, Noel A, Cataldo DD Mouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation, and cytokine production. Inflamm. Res., 2009-06-09;58(12):845-54. 2009-06-09 [PMID: 19506803] (Mouse)
• Hayasaka D, Nagata N, Fujii Y, Hasegawa H, Sata T, Suzuki R, Gould EA, Takashima I, Koike S Mortality following peripheral infection with tick-borne encephalitis virus results from a combination of central nervous system pathology, systemic inflammatory and stress responses. Virology, 2009-05-24;390(1):139-50. 2009-05-24 [PMID: 19467556] (Mouse)
• Thomay AA, Daley JM, Sabo E, Worth PJ, Shelton LJ, Harty MW, Reichner JS, Albina JE Disruption of interleukin-1 signaling improves the quality of wound healing. Am. J. Pathol., 2009-04-23;174(6):2129-36. 2009-04-23 [PMID: 19389930] (Mouse)
• Kharabi Masouleh B, ten Dam GB, Wild MK, Seelige R, van der Vlag J, Rops AL, Echtermeyer FG, Vestweber D, van Kuppevelt TH, Kiesel L, Gotte M Role of the heparan sulfate proteoglycan syndecan-1 (CD138) in delayed-type hypersensitivity. J. Immunol., 2009-04-15;182(8):4985-93. 2009-04-15 [PMID: 19342678] (Mouse)
• Shinagawa K, Ploplis VA, Castellino FJ A severe deficiency of coagulation factor VIIa results in attenuation of the asthmatic response in mice. Am. J. Physiol. Lung Cell Mol. Physiol., 2009-03-13;296(5):L763-70. 2009-03-13 [PMID: 19286924] (Mouse)
• Li H, Ciric B, Yang J, Xu H, Fitzgerald DC, Elbehi M, Fonseca-Kelly Z, Yu S, Zhang GX, Rostami A Intravenous tolerance modulates macrophage classical activation and antigen presentation in experimental autoimmune encephalomyelitis. J. Neuroimmunol., 2009-02-01;208(1):54-60. 2009-02-01 [PMID: 19187972] (Mouse)
• Hirota Y, Tranguch S, Daikoku T, Hasegawa A, Osuga Y, Taketani Y, Dey SK Deficiency of immunophilin FKBP52 promotes endometriosis. Am. J. Pathol., 2008-11-06;173(6):1747-57. 2008-11-06 [PMID: 18988805] (Mouse)
• Ohba T, Haro H, Ando T, Koyama K, Hatsushika K, Suenaga F, Ohnuma Y, Nakamura Y, Katoh R, Ogawa H, Hamada Y, Nakao A A potential role of thymic stromal lymphopoietin in the recruitment of macrophages to mouse intervertebral disc cells via monocyte chemotactic protein 1 induction: implications for herniated discs. Arthritis Rheum., 2008-11-01;58(11):3510-9. 2008-11-01 [PMID: 18975342] (Mouse)
• Da Silva CA, Hartl D, Liu W, Lee CG, Elias JA TLR-2 and IL-17A in chitin-induced macrophage activation and acute inflammation. J. Immunol., 2008-09-15;181(6):4279-86. 2008-09-15 [PMID: 18768886] (Mouse)
• Di Liberto D, Locati M, Caccamo N, Vecchi A, Meraviglia S, Salerno A, Sireci G, Nebuloni M, Caceres N, Cardona PJ, Dieli F, Mantovani A Role of the chemokine decoy receptor D6 in balancing inflammation, immune activation, and antimicrobial resistance in Mycobacterium tuberculosis infection. J. Exp. Med., 2008-08-11;205(9):2075-84. 2008-08-11 [PMID: 18695004] (Mouse)
• Pillai RG, Beutelspacher SC, Larkin DF, George AJ Expression of the chemokine antagonist vMIP II using a non-viral vector can prolong corneal allograft survival. Transplantation, 2008-06-15;85(11):1640-7. 2008-06-15 [PMID: 18551072] (Mouse)
• Schafer A, Pfrang J, Neumuller J, Fiedler S, Ertl G, Bauersachs J The cannabinoid receptor-1 antagonist rimonabant inhibits platelet activation and reduces pro-inflammatory chemokines and leukocytes in Zucker rats. Br. J. Pharmacol., 2008-05-12;154(5):1047-54. 2008-05-12 [PMID: 18469848] (Rat)
• Cho YS, Oh SY, Zhu Z Tyrosine phosphatase SHP-1 in oxidative stress and development of allergic airway inflammation. Am. J. Respir. Cell Mol. Biol., 2008-04-25;39(4):412-9. 2008-04-25 [PMID: 18441283] (Mouse)
• Trujillo G, O'Connor EC, Kunkel SL, Hogaboam CM A novel mechanism for CCR4 in the regulation of macrophage activation in bleomycin-induced pulmonary fibrosis. Am. J. Pathol., 2008-04-10;172(5):1209-21. 2008-04-10 [PMID: 18403600] (Mouse)
• Cash JL, Hart R, Russ A, Dixon JP, Colledge WH, Doran J, Hendrick AG, Carlton MB, Greaves DR Synthetic chemerin-derived peptides suppress inflammation through ChemR23. J. Exp. Med., 2008-04-07;205(4):767-75. 2008-04-07 [PMID: 18391062] (Mouse)
• Terme M, Chaput N, Combadiere B, Ma A, Ohteki T, Zitvogel L Regulatory T cells control dendritic cell/NK cell cross-talk in lymph nodes at the steady state by inhibiting CD4+ self-reactive T cells. J. Immunol., 2008-04-01;180(7):4679-86. 2008-04-01 [PMID: 18354191] (Mouse)
• De Filippo K, Henderson RB, Laschinger M, Hogg N Neutrophil chemokines KC and macrophage-inflammatory protein-2 are newly synthesized by tissue macrophages using distinct TLR signaling pathways. J. Immunol., 2008-03-15;180(6):4308-15. 2008-03-15 [PMID: 18322244] (Mouse)
• Bartlett NW, Walton RP, Edwards MR, Aniscenko J, Caramori G, Zhu J, Glanville N, Choy KJ, Jourdan P, Burnet J, Tuthill TJ, Pedrick MS, Hurle MJ, Plumpton C, Sharp NA, Bussell JN, Swallow DM, Schwarze J, Guy B, Almond JW, Jeffery PK, Lloyd CM, Papi A, Killington RA, Rowlands DJ, Blair ED, Clarke NJ, Johnston SL Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation. Nat. Med., 2008-02-03;14(2):199-204. 2008-02-03 [PMID: 18246079] (Mouse)
• Maret M, Ruffie C, Periquet B, Campo AM, Menevret M, Phelep A, Dziewiszek K, Druilhe A, Pretolani M Liposomal retinoic acids modulate asthma manifestations in mice. J. Nutr., 2007-12-01;137(12):2730-6. 2007-12-01 [PMID: 18029491] (Mouse)
• Fujita H, Asahina A, Komine M, Tamaki K The direct action of 1alpha,25(OH)2-vitamin D3 on purified mouse Langerhans cells. Cell. Immunol., 2007-05-15;245(2):70-9. 2007-05-15 [PMID: 17507001] (Mouse)
• Robays LJ, Maes T, Lebecque S, Lira SA, Kuziel WA, Brusselle GG, Joos GF, Vermaelen KV Chemokine receptor CCR2 but not CCR5 or CCR6 mediates the increase in pulmonary dendritic cells during allergic airway inflammation. J. Immunol., 2007-04-15;178(8):5305-11. 2007-04-15 [PMID: 17404315] (Mouse)
• Hamdi H, Godot V, Maillot MC, Prejean MV, Cohen N, Krzysiek R, Lemoine FM, Zou W, Emilie D Induction of antigen-specific regulatory T lymphocytes by human dendritic cells expressing the glucocorticoid-induced leucine zipper. Blood, 2007-03-13;110(1):211-9. 2007-03-13 [PMID: 17356131]
• Johnson LA, Clasper S, Holt AP, Lalor PF, Baban D, Jackson DG An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium. J. Exp. Med., 2006-11-20;203(12):2763-77. 2006-11-20 [PMID: 17116732] (Mouse)
• Drmotova M, Rehnstrom E, Jansson L Local production of chemokines and prostaglandin E2 in the acute, chronic and recovery phase of murine experimental colitis. Cytokine, 2006-11-07;35(5):275-83. 2006-11-07 [PMID: 17088072] (Mouse)
• Ando T, Ichikawa J, Wako M, Hatsushika K, Watanabe Y, Sakuma M, Tasaka K, Ogawa H, Hamada Y, Yagita H, Nakao A TWEAK/Fn14 interaction regulates RANTES production, BMP-2-induced differentiation, and RANKL expression in mouse osteoblastic MC3T3-E1 cells. Arthritis Res. Ther., 2006-01-01;8(5):R146. 2006-01-01 [PMID: 16945157] (Mouse)
• Bhagwat SP, Gigliotti F, Xu H, Wright TW Contribution of T cell subsets to the pathophysiology of Pneumocystis-related immunorestitution disease. Am. J. Physiol. Lung Cell Mol. Physiol., 2006-08-04;291(6):L1256-66. 2006-08-04 [PMID: 16891394] (Mouse)
• Lama VN, Harada H, Badri LN, Flint A, Hogaboam CM, McKenzie A, Martinez FJ, Toews GB, Moore BB, Pinsky DJ Obligatory role for interleukin-13 in obstructive lesion development in airway allografts. Am. J. Pathol., 2006-07-01;169(1):47-60. 2006-07-01 [PMID: 16816360] (Mouse)
• Weighardt H, Mages J, Jusek G, Kaiser-Moore S, Lang R, Holzmann B Organ-specific role of MyD88 for gene regulation during polymicrobial peritonitis. Infect. Immun., 2006-06-01;74(6):3618-32. 2006-06-01 [PMID: 16714594] (Mouse)
• Liu Q, Chen T, Chen G, Li N, Wang J, Ma P, Cao X Immunosuppressant triptolide inhibits dendritic cell-mediated chemoattraction of neutrophils and T cells through inhibiting Stat3 phosphorylation and NF-kappaB activation. Biochem. Biophys. Res. Commun., 2006-05-12;345(3):1122-30. 2006-05-12 [PMID: 16713992] (Mouse)
• Alvarez D, Swirski FK, Yang TC, Fattouh R, Croitoru K, Bramson JL, Stampfli MR, Jordana M Inhalation tolerance is induced selectively in thoracic lymph nodes but executed pervasively at distant mucosal and nonmucosal tissues. J. Immunol., 2006-02-15;176(4):2568-80. 2006-02-15 [PMID: 16456019] (Mouse)
• Biswas SK, Gangi L, Paul S, Schioppa T, Saccani A, Sironi M, Bottazzi B, Doni A, Vincenzo B, Pasqualini F, Vago L, Nebuloni M, Mantovani A, Sica A A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation). Blood, 2005-11-03;107(5):2112-22. 2005-11-03 [PMID: 16269622] (Mouse)
• Trabattoni D, Clivio A, Bray DH, Bhagat L, Beltrami S, Maffeis G, Cesana E, Lowry P, Lissoni F, Kandimalla ER, Sullivan T, Agrawal S, Bartholomew R, Clerici M Immunization with gp120-depleted whole killed HIV immunogen and a second-generation CpG DNA elicits strong HIV-specific responses in mice. Vaccine, 2005-09-22;24(9):1470-7. 2005-09-22 [PMID: 16221513] (Mouse)
• Hofstetter C, Flondor M, Hoegl S, Muhl H, Zwissler B Interleukin-10 aerosol reduces proinflammatory mediators in bronchoalveolar fluid of endotoxemic rat. Crit. Care Med., 2005-10-01;33(10):2317-22. 2005-10-01 [PMID: 16215387] (Rat)
• Harandi AM, Eriksson K, Holmgren J A protective role of locally administered immunostimulatory CpG oligodeoxynucleotide in a mouse model of genital herpes infection. J. Virol., 2003-01-01;77(2):953-62. 2003-01-01 [PMID: 12502811] (Mouse)
• Garcia-Ramallo E, Marques T, Prats N, Beleta J, Kunkel SL, Godessart N Resident cell chemokine expression serves as the major mechanism for leukocyte recruitment during local inflammation. J. Immunol., 2002-12-01;169(11):6467-73. 2002-12-01 [PMID: 12444156] (Mouse)
• Menten P, Saccani A, Dillen C, Wuyts A, Struyf S, Proost P, Mantovani A, Wang JM, Van Damme J Role of the autocrine chemokines MIP-1alpha and MIP-1beta in the metastatic behavior of murine T cell lymphoma. J. Leukoc. Biol., 2002-10-01;72(4):780-9. 2002-10-01 [PMID: 12377948] (Mouse)
• Faunce DE, Stein-Streilein J NKT cell-derived RANTES recruits APCs and CD8+ T cells to the spleen during the generation of regulatory T cells in tolerance. J. Immunol., 2002-07-01;169(1):31-8. 2002-07-01 [PMID: 12077225] (Mouse)
• Horner AA, Datta SK, Takabayashi K, Belyakov IM, Cinman N, Nguyen MD, Van Uden JH, Berzofsky JA Immunostimulatory DNA-based vaccines elicit multifaceted immune responses against HIV at systemic and mucosal sites. J. Immunol., 2001-08-01;167(3):1584-91. 2001-08-01 [PMID: 11466380] (Mouse)
• Hanisch UK, Prinz M, Angstwurm K, Hausler KG, Kann O, Kettenmann H, Weber JR The protein tyrosine kinase inhibitor AG126 prevents the massive microglial cytokine induction by pneumococcal cell walls. Eur. J. Immunol., 2001-07-01;31(7):2104-15. 2001-07-01 [PMID: 11449364] (Mouse)
• Bless NM, Huber-Lang M, Guo RF, Warner RL, Schmal H, Czermak BJ, Shanley TP, Crouch LD, Lentsch AB, Sarma V, Mulligan MS, Friedl HP, Ward PA Role of CC chemokines (macrophage inflammatory protein-1 beta, monocyte chemoattractant protein-1, RANTES) in acute lung injury in rats. J. Immunol., 2000-03-01;164(5):2650-9. 2000-03-01 [PMID: 10679105] (Rat)

Bioinformatics

• Gene Symbol: Ccl5