Mouse Progranulin Quantikine ELISA Kit

• Reactivity: Mu
• Applications: ELISA
• Conjugate: HRP

Mouse Progranulin Quantikine ELISA Kit Summary

• Background: The Quantikine^® Mouse Progranulin Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse Progranulin in cell culture supernates, tissue culture supernates, serum, and plasma. It contains NS0-expressed recombinant mouse Progranulin and has been shown to accurately quantitate the recombinant factor. Results obtained using natural Progranulin showed linear curves that... were parallel to the standard curves obtained using the Quantikine^® kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse Progranulin.
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• Specificity: Natural and recombinant mouse Progranulin.
• Source: N/A
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse Progranulin Quantikine ELISA Kit

• Acrogranin
• CLN11
• GEP
• GP88
• granulin precursor
• GRN
• PCDGF
• PEPI
• PGRN
• Proepithelin
• Progranulin

Background

Progranulin, also known as Acrogranin, PCDGF, and Epithelin/Granulin Precursor, is a widely expressed glycoprotein that can undergo proteolysis to generate numerous Granulin peptides. Progranulin plays a role in the regulation of mesothelial differentiation, macrophage development, sexual differentiation of the brain, cartilage proliferation, wound repair, and the development of rheumatoid arthritis and osteoarthritis. It is often upregulated in cancer and contributes to tumor progression. Progranulin upregulation or mutation is associated with several neurological disorders including frontotemporal dementia, Creutzfeldt-Jakob disease, Alzheimer’s disease, and motor neuron disease.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for Progranulin/PGRN (MPGRN0)(4)

Publications using MPGRN0

• McElhanon, KE;Huff, TC;Hirenallur-Shanthappa, D;Miller, RA;Christoforou, N; Increased circulating progranulin is not sufficient to induce cardiac dysfunction or supraventricular arrhythmia Scientific reports 2023-12-06 [PMID: 38057339] (Mouse)
• MN Santos, DH Paushter, T Zhang, X Wu, T Feng, J Lou, H Du, SM Becker, R Fragoza, H Yu, F Hu Progranulin-derived granulin E and lysosome membrane protein CD68 interact to reciprocally regulate their protein homeostasis The Journal of Biological Chemistry, 2022-08-04;0(0):102348. 2022-08-04 [PMID: 35933009] (Mouse)
• K Ritter, K Jung, C Dolderer, D Appel, CC Oswald, U Ritz, MKE Schäfer Early Reciprocal Effects in a Murine Model of Traumatic Brain Injury and Femoral Fracture Mediators of Inflammation, 2021-01-18;2021(0):8835730. 2021-01-18 [PMID: 33531878] (Mouse)
• S Miyakawa, H Sakuma, D Warude, S Asanuma, N Arimura, T Yoshihara, D Tavares, A Hata, K Ida, Y Hori, Y Okuzono, S Yamamoto, K Iida, H Shimizu, S Kondo, S Sato Anti-sortilin1 Antibody Up-Regulates Progranulin via Sortilin1 Down-Regulation Frontiers in Neuroscience, 2020-12-15;14(0):586107. 2020-12-15 [PMID: 33384578] (Mouse)