Mouse Progranulin DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse Progranulin DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Grn

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse Progranulin DuoSet ELISA, 15 Plate

• Acrogranin
• CLN11
• GEP
• GP88
• granulin precursor
• GRN
• PCDGF
• PEPI
• PGRN
• Proepithelin
• Progranulin

Background

Progranulin, also known as Acrogranin, PCDGF, and Epithelin/Granulin Precursor, is a widely expressed glycoprotein that can undergo proteolysis to generate numerous Granulin peptides. Progranulin plays a role in the regulation of mesothelial differentiation, macrophage development, sexual differentiation of the brain, cartilage proliferation, wound repair, and the development of rheumatoid arthritis and osteoarthritis. It is often upregulated in cancer and contributes to tumor progression. Progranulin upregulation or mutation is associated with several neurological disorders including frontotemporal dementia, Creutzfeldt-Jakob disease, Alzheimer’s disease, and motor neuron disease.

Publications for Progranulin/PGRN (DY2557)(3)

Publications using DY2557

• Kurnellas, M;Mitra, A;Schwabe, T;Paul, R;Arrant, AE;Roberson, ED;Ward, M;Yeh, F;Long, H;Rosenthal, A; Latozinemab, a novel progranulin-elevating therapy for frontotemporal dementia Journal of translational medicine 2023-06-15 [PMID: 37322482] (Transgenic Mouse)
• A Schmid, M Roderfeld, J Gehl, E Roeb, A Nist, HR Chung, T Stiewe, T Karrasch, A Schäffler C1q/TNF-Related Protein 3 (CTRP-3) Deficiency of Adipocytes Affects White Adipose Tissue Mass but Not Systemic CTRP-3 Concentrations International Journal of Molecular Sciences, 2021-02-07;22(4):. 2021-02-07 [PMID: 33562308] (Mouse)
• S Miyakawa, H Sakuma, D Warude, S Asanuma, N Arimura, T Yoshihara, D Tavares, A Hata, K Ida, Y Hori, Y Okuzono, S Yamamoto, K Iida, H Shimizu, S Kondo, S Sato Anti-sortilin1 Antibody Up-Regulates Progranulin via Sortilin1 Down-Regulation Frontiers in Neuroscience, 2020-12-15;14(0):586107. 2020-12-15 [PMID: 33384578] (Mouse)

Bioinformatics

• Gene Symbol: Grn