Neutrophil Elastase/ELA2 Products

Description

The ELANE gene (commonly known as neutrophil elastase) encodes a 267 amino acid long, 28 kDA neutrophil elastase protein that functions in regulation of natural killer cells, monocytes, and graulocytes. ELANE is involved in activation of proMMP8, cell adhesion cell-matrix glycoconjugates, selected targets of C/EBPbeta, degradation of the extracellular matrix and collagen, and amb2 integrin signaling. It interacts with various genes GZMB, LRP1, SERPINF2, SERPING1, and SERPINA1. Elane has been linked to cystic fibrosis, asthma, pneumonia, alzheimer's disease, neutropenia, cutis laxia, leg ulcers, wegener's granulomatosis, bronchitis, adult respiratory distress syndrome, and vascular diseases.

Bioinformatics

Uniprot	NM_001972 Human P08246 Human NP_001963 Human
Product By Gene ID	1991
Alternate Names	EC 3.4.21 GE Medullasin SCN1 Elastase-2 PMN elastase EC 3.4.21.37 Human leukocyte elastase polymorphonuclear elastase Bone marrow serine protease neutrophil elastase elastase 2, neutrophil medullasin NE leukocyte elastase HNE ELA2granulocyte-derived elastase HLEelastase-2 PMN-E elastase, neutrophil expressed

Diseases related to Neutrophil Elastase/ELA2

Discover more about diseases related to Neutrophil Elastase/ELA2.

Severe Congenital Neutropenia
Leukemia
Cyclic Neutropenia
Infective Disorder
Bacterial Infections
Growth Arrest
Neutropenia Chronic
Malignant Paraganglionic Neoplasm
Lung Diseases
Pancytopenia
Immunologic Deficiency Syndromes
Malignant Neoplasms
Neoplasms
Myeloid Leukemia
Hereditary Diseases
Leukemia, Myelocytic, Acute
Dysmyelopoietic Syndromes
Wiskott-aldrich Syndrome

Pathways for Neutrophil Elastase/ELA2

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Pathogenesis
Cell Proliferation
Proteolysis
Wound Healing
Neutrophil Activation

Research Areas for Neutrophil Elastase/ELA2

Find related products by research area and learn more about each of the different research areas below.

Cancer
Neuroscience

Bioinformatics Tool for Neutrophil Elastase/ELA2

Discover related pathways, diseases and genes to Neutrophil Elastase/ELA2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.