Species: Hu
Applications: WB, Flow, IHC, CyTOF-ready, ICC/IF
Host: Mouse Monoclonal
Species: Hu, Mu
Applications: WB, Flow, ICC/IF, IHC, IHC-P
Host: Rabbit Monoclonal
Species: Hu, Pm
Applications: WB, ELISA, Flow, IHC, IHC-P
Host: Mouse Monoclonal
Species: Mu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Mu
Applications: ELISA
Species: Hu
Applications: WB
Species: Mu
Applications: Enzyme Activity
Species: Hu
Applications: Enzyme Activity
Species: Hu
Applications: AC
Description
The ELANE gene (commonly known as neutrophil elastase) encodes a 267 amino acid long, 28 kDA neutrophil elastase protein that functions in regulation of natural killer cells, monocytes, and graulocytes. ELANE is involved in activation of proMMP8, cell adhesion cell-matrix glycoconjugates, selected targets of C/EBPbeta, degradation of the extracellular matrix and collagen, and amb2 integrin signaling. It interacts with various genes GZMB, LRP1, SERPINF2, SERPING1, and SERPINA1. Elane has been linked to cystic fibrosis, asthma, pneumonia, alzheimer's disease, neutropenia, cutis laxia, leg ulcers, wegener's granulomatosis, bronchitis, adult respiratory distress syndrome, and vascular diseases.
Bioinformatics
Uniprot |
Human Human Human |
Product By Gene ID |
1991 |
Alternate Names |
- EC 3.4.21
- GE
- Medullasin
- SCN1
- Elastase-2
- PMN elastase
- EC 3.4.21.37
- Human leukocyte elastase
- polymorphonuclear elastase
- Bone marrow serine protease
- neutrophil elastase
- elastase 2, neutrophil
- medullasin
- NE
- leukocyte elastase
- HNE
- ELA2granulocyte-derived elastase
- HLEelastase-2
- PMN-E
- elastase, neutrophil expressed
|
Research Areas for Neutrophil Elastase/ELA2
Find related products by research area and learn more about each of the different research areas below.
CancerNeuroscience
Bioinformatics Tool for Neutrophil Elastase/ELA2
Discover related pathways, diseases and genes to Neutrophil Elastase/ELA2. Need help? Read the
Bioinformatics Tool Guide for instructions on using this tool.